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| 1 | Previous hepatitis B viral infection–an underestimated cause of pancreatic cancer显示文摘BACKGROUND The etiology of pancreatic cancer remains unclear. This limits the possibility of prevention and effective treatment. Hepatitis B virus(HBV) is responsible for the development of different types of cancer, but its role in pancreatic cancer is still being discussed.AIM To assess the prevalence of previous HBV infection and to identify viral biomarkers in patients with pancreatic ductal adenocarcinoma(PDAC) to support the role of the virus in etiology of this cancer.METHODS The data of 130 hepatitis B surface antigen-negative subjects were available for the final analysis,including 60 patients with PDAC confirmed by cytology or histology and 70 sex-and age-matched controls. All the participants were tested for HBV biomarkers in blood [antibody to hepatitis B core antigen(anti-HBc), antibody to hepatitis B surface antigen(anti-HBs) and HBV DNA], and for those with PDAC, biomarkers in resected pancreatic tissues were tested(HBV DNA, HBV pregenomic RNA and covalently closed circular DNA). We performed immunohistochemistry staining of pancreatic tissues for hepatitis B virus X antigen and Ki-67 protein. Non-parametric statistics were used for the analysis.RESULTS Anti-HBc was detected in 18/60(30%) patients with PDAC and in 9/70(13%) participants in the control group(P = 0.029). Accordingly, the odds of PDAC in anti-HBc-positive subjects were higher compared to those with no previous HBV infection(odds ratio: 2.905, 95% confidence interval: 1.191-7.084, standard error 0.455). HBV DNA was detected in 8 cases of PDAC and in 6 of them in the pancreatic tumor tissue samples only(all patients were anti-HBc positive). Blood HBV DNA was negative in all subjects of the control group with positive results of the serum anti-HBc test. Among 9 patients with PDAC, 5 revealed signs of replicative competence of the virus(covalently closed circular DNA with or without pregenomic RNA) in the pancreatic tumor tissue samples. Hepatitis B virus X antigen expression and active cell proliferation was revealed by immunohistochemistry in 4 patients with PDAC in the pancreatic tumor tissue samples.CONCLUSION We found significantly higher risks of PDAC in anti-HBc-positive patients. Detection of viral replication and hepatitis B virus X protein expression in the tumor tissue prove involvement of HBV infection in pancreatic cancer development. | Sergey Batskikh Sergey Morozov Alexey Dorofeev Zanna Borunova Dmitry Kostyushev Sergey Brezgin Anastasiya Kostyusheva Vladimir Chulanov | 2022 | World Journal of Gastroenterology2022，28，33： | 2 |
| 2 | Specific codon 13 K- ras mutations are predictive of clinical outcome in eolorectal cancer patients, whereas eodon 12 K-ras mutations are associated with mucinous histotype 显示文摘 | Bazan V Migliavaeea M Zanna I | 2002 | Ann Oneol2002，13，： | 1 |
| 3 | Lie-group Methods显示文摘 | ISERLES A MUNTHE-KAAS H Z Nφrsett S P ZANNA A | 2000 | Acta Numerica2000，9，： | 1 |
| 4 | Secure and defensive high self-esteem 显示文摘 | JORDAN C H SPENCER S J ZANNA M P | 2003 | Journal of Personality andSocial Psychology2003，，5： | 1 |
| 5 | XPS and STM study of the growth and structure of passive films in high tem- perature water on a nickel-base alloy 显示文摘 | Zanna S Maurice V Jolivet P | 2004 | Electrochimica ACTA2004，49，22： | 1 |
| 6 | Trust in close relationships显示文摘 | Rempel J K Holmes J G Zanna M P | 1985 | Journal of Personality and Social Psychology1985，49，： | 1 |
| 7 | Glycosaminoglycan-resistant and pH-sensitive lipid-coated DNA complexes produced by detergent removal method显示文摘 | Lehtinen J Zanna H Urtti A | 2008 | J Controlled Release2008，131，2： | 1 |
| 8 | XPS study of initial stage of oxidation behavior of tt2-Ti3Al and T-TiA1 intermetallic alloy 显示文摘 | MAURICE V DESPERT C~ ZANNA S | 2007 | Acta Mater2007，55，10： | 1 |
| 9 | Role of G protein-coupled receptor kinases in the homologous desensitization of the human and mouse melanocortin1 receptors显示文摘 | Sánchez-Más J Guillo LA Zanna P Jiménez-Cervantes C García-Borrón JC | 2005 | Mol Endocrinol2005，19，4： | 1 |
| 10 | Prognostic significance of p16INK4a alterations and 9p21 loss of heterozygosity in locally advanced laryngeal squamous cell carcinoma显示文摘 | Bazan V Zanna I Migliavacca M | 2002 | J Cell Physiol2002，192，3： | 1 |
| 11 | Degradation of Agro-Waste by Cellulase from Aspergillus candidus 显示文摘 | MILALA M A SHEHU B B ZANNA H | 2009 | Asian Biotechnol2009，1，2： | 1 |
| 12 | The recombinant Klebsiella pneumoniae outer membrane protein OmpA has carrier properties for conjugated antigenic peptides显示文摘 | Haeuw JF Rauly I Zanna L | 1998 | Eur J Biochem1998，255，2： | 1 |
| 13 | Prognostic signi -ficance of p16 INK4a alterations and 9p21 loss of heterozygosity in locally advanced laryngeal squamous cell carcinoma 显示文摘 | Bazan V Zanna I Migliacca M | 2002 | J Cell Physiol2002，192，3： | 1 |
| 14 | Prognostic significance of p16 in K4a alterations and 9p21 loss of heterozygosity in locally advanced laryngeal squamous cell carcinoma显示文摘 | BAZAN V ZANNA I MIGLIACCA M | 2002 | J Cell Physiol2002，192，3： | 1 |
| 15 | Inducing hypocrisy to reduce prejudicial responses among aversive racists显示文摘 | SON-HING LS LI W N ZANNA M P | 2002 | Journal of Experimental Social Psychology2002，38，： | 1 |
| 16 | Gene-Stress- Epigenetic Regulation of FKBPS: Clinical and Translational Implications显示文摘 | Zannas A S Wiechmann T Gassen N C | 2015 | Neuropsychopharmacology2015，16，2： | 1 |
| 17 | Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction显示文摘 | PITT B REMME W ZANNA F | 2003 | N Engl J Med2003，348，： | 1 |
| 18 | Role of pH and Calcium Ions in the Adsorption of an Alkyl Naminodimethylphos-phonate on Steel:An XPS study显示文摘 | Frateur I Carnot A Zanna S | 2006 | Applied Surface Science2006，252，： | 1 |
| 19 | Why mitochondria must fuse to maintain their genome integrity 显示文摘 | Vidoni S Zanna C Rugolo M | 2013 | Antioxidants & re- dox signaling2013，19，4： | 1 |
| 20 | Hereditary common cancers:molecular and clinical genetics 显示文摘 | Zanna I Tubiolo C | 2000 | Anticancer Res2000，20，6： | 1 |
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