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| 1 | High expression levels of IKK alpha and IKK beta are necessary for the malignant properties of liver cancer显示文摘IKK-NF-kappa B signaling is regarded as an important factor in hepatocarcinogenesis and a potential target for liver cancer therapy.Therefore,in this study,we analyzed the expression of mRNAs encoding components and targets of NF-kappa B signaling including IKK alpha,IKK beta,RANK,RANKL,OPG,CyclinD3,mammary serine protease inhibitor(Maspin),CyclinD1,c-FLIP,Bcl-x1,Stat3,Cip1 and Cip2 by real-time PCR in 40 patients with liver cancer.After statistical analysis,7 indices including IKK alpha,IKK beta,RANK,Maspin,c-FLIP,Cip2 and cyclinD1 were found to show significant differences between tumor tissue and its corresponding adjacent tissue.When IKK alpha and IKK beta were downregulated in the hepatocellular carcinoma(HCC) cell lines of MHCC-97L and MHCC-97H in vitro,the numbers of BrdU positive cells were decreased in both IKK alpha and IKK beta knockdown cells.Levels of apoptosis were also investigated in IKK alpha and IKK beta knockdown cells.The growth of HCC was inhibited in the subcutaneous implantation model,and lung metastatogenesis was also significantly inhibited in the kidney capsule transplantation model.Downregulation of IKK alpha and IKK beta in HCC cultured in vitro revealed that increased Maspin,OPG and RANKL expression was associated with metastasis of HCC.These findings were associated with downregulation of Bcl-XL and c-FLIP,which may be the reason for increased apoptosis.The therapeutic effect of IKK alpha and IKK beta downregulation depends on extent of NF-kappa B inhibition and the malignant nature of the HCC.We anticipate that IKK-targeted gene therapy can be used in the treatment of HCC,a cancer that is notoriously resistant to radiation and chemotherapy. | Jiang,RQ Xia,YX Li,J Deng,L Zhao,L Shi,J Wang,XH Sun,BC Nanjing Med Univ,Liver Transplantat Ctr,Affiliated Hosp 1,Nanjing,Jiangsu Prov,Peoples R China Nanjing Med Univ,Ctr Canc,Nanjing,Jiangsu Prov,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 13 |
| 2 | Mixed-layer water oscillations in tropical Pacific for ENSO cycle显示文摘The main modes of interannal variabilities of thermocline and sea surface wind stress in the tropical Pacific and their interactions are investigated,which show the following results.(1) The thermocline anomalies in the tropical Pacific have a zonal dipole pattern with 160°W as its axis and a meridional seesaw pattern with 6-8°N as its transverse axis.The meridional oscillation has a phase lag of about 90° to the zonal oscillation,both oscillations get together to form the El Ni?o/La Ni?a cycle,which be-haves as a mixed layer water oscillates anticlockwise within the tropical Pacific basin between equator and 12°N.(2) There are two main patterns of wind stress anomalies in the tropical Pacific,of which the first component caused by trade wind anomaly is characterized by the zonal wind stress anomalies and its corresponding divergences field in the equatorial Pacific,and the abnormal cross-equatorial flow wind stress and its corresponding divergence field,which has a sign opposite to that of the equatorial region,in the off-equator of the tropical North Pacific,and the second component represents the wind stress anomalies and corresponding divergences caused by the ITCZ anomaly.(3) The trade winds anomaly plays a decisive role in the strength and phase transition of the ENSO cycle,which results in the sea level tilting,provides an initial potential energy to the mixed layer water oscillation,and causes the opposite thermocline displacement between the west side and east side of the equator and also between the equator and 12°N of the North Pacific basin,therefore determines the amplitude and route for ENSO cycle.The ITCZ anomaly has some effects on the phase transition.(4) The thermal anomaly of the tropical western Pacific causes the wind stress anomaly and extends eastward along the equator accompanied with the mixed layer water oscillation in the equatorial Pacific,which causes the trade winds anomaly and produces the anomalous wind stress and the corresponding divergence in favor to conduce the oscillation,which in turn intensifies the oscillation.The coupled system of ocean-atmo-sphere interactions and the inertia gravity of the mixed layer water oscillation provide together a phase-switching mechanism and interannual memory for the ENSO cycle.In conclusion,the ENSO cycle essentially is an inertial oscillation of the mixed layer water induced by both the trade winds anomaly and the coupled ocean-atmosphere interaction in the tropical Pacific basin between the equator and 12°N.When the force produced by the coupled ocean-atmosphere interaction is larger than or equal to the resistance caused by the mixed layer water oscillation,the oscillation will be stronger or maintain as it is,while when the force is less than the resistance,the oscillation will be weaker,even break. | ZHAO YongPing1,CHEN YongLi1,WANG Fan1 & WU AiMing2 1 Institute of Oceanology,Chinese Academy of Sciences,Qingdao 266071,China 2 Department of Earth & Ocean Sciences,University of British Columbia,Vancouver,BC,V6T 1Z4,Canada | 2007 | Science China Earth Sciences2007，50，12： | 7 |
| 3 | In vitro assessment of cellular responses to rod-shaped hydroxyapatite nanoparticles of varying lengths and surface areas显示文摘 | Zhao X Heng BC Xiong S | 2011 | Nanotoxicology2011，5，2： | 1 |
| 4 | Zonula occludens- 1 and E- cadherin are coordinately expressed in the mouse uterus with the initiation of implantation and decidualization显示文摘 | Zhao X Das SK | 1999 | Dev Biol1999，208，2： | 1 |
| 5 | Extracellular signal-regulated ki- nase-regulated microglia-neuron signaling by prostaglandin E2 contributes to pain after spinal cord injury 显示文摘 | Zhao P Waxman SG Hains BC | 2007 | J Neurosci2007，27，9： | 1 |
| 6 | The effects of alternative stress on the cell membrane deformability of Chrysanthemum cells 显示文摘 | Wang BC Zhao HC Liu YY | 2001 | Colloids and Surfaces B: Biointerfaces2001，20，： | 1 |
| 7 | The autophagy gene ATG5 plays an essential role in B lymphocyte development显示文摘 | Miller BC Zhao Z Stephenson LM | 2008 | Autophagy2008，4，3： | 1 |
| 8 | Sodium channel expression in the ventral posterolateral nucleus of the thalamus after pe-ripheral nerve injury显示文摘 | Zhao P Waxman SG Hains BC | | 0，，02： | 1 |
| 9 | Preferable removal of phosphate from water using hydrous zirconium oxide- based nanocomposite of high stabilitymicrospheres 显示文摘 | Chen L Zhao X Pan BC | 2015 | Journal of Hazardous Materials2015，284，： | 1 |
| 10 | The tomato homolog of coronatine-insensitivel is required for the maternal control of seed maturation,jasmonate-signaled defense responses and glandular trichome development显示文摘 | Li L Zhao Y McCaig BC Wingerd BA Wang JH Whalon ME Pichersky E Howe GA | | 0，，01： | 1 |
| 11 | Cyclooxygenase-2 differentially directs uterine angiogenesis during implantation in mice显示文摘 | Matsumoto H Ma WG Daikoku T Zhao X Paria BC Das SK Trzaskos JM Dey SK | 2002 | J Biol Chem2002，9277，29： | 1 |
| 12 | The effects of alternative stress on the cell membrane deformability of Chrysanthemum cells显示文摘 | Wang BC Zhao HC Liu YY | 2001 | Colloids Surfaces B:Biointerfaces2001，20，： | 1 |
| 13 | Clinical observation of 44 cases of avermeetina in treatment of multiple verruea plantaris显示文摘 | Fang F Zhao Y Lv BC | 2009 | Fu- jian Med J2009，31，2： | 1 |
| 14 | Hypoxia-induced vasculogenic mimicry formation via VE-cadherin regulation by Bcl-2显示文摘 | Zhao N Sun BC Sun T | 2012 | Mied Oncol2012，29，5： | 1 |
| 15 | Vasculogenic mimicry is associated with shorter survival in hepatocellular carcinomas显示文摘 | Sun BC Zhang SW Zhao XL | | Laboratory Investigation0，，： | 1 |
| 16 | Diversity of both the cultivable protease-producing bacteria and their extracellular proteases in the sediments of the South China Sea显示文摘 | Zhou MY Chen XL Zhao HL Dang HY Luan XW Zhang XY He HL Zhou BC and Zhang YZ | | 0，，03： | 1 |
| 17 | Corticosterone promotes increased heine oxygenase-2 protein and transcript expression in the newborn rat brain显示文摘 | Maines MD Eke BC Zhao X | 1996 | Brain Res1996，722，12： | 1 |
| 18 | Sodium channel expression in the ventral posterolateral nucleus of the thalamus after peripheral nerve in- jury显示文摘 | Zhao P Waxman SG Hains BC | 2006 | Mol Pain2006，2，： | 1 |
| 19 | The tomato homolog of CORONATINE - INSENSITIVE1 is required for the maternal control of seed maturation, jasmonate - signaled defense responses, and glandular trichome development显示文摘 | Li L Zhao Y McCaig BC | 2004 | Plant Cell2004，16，： | 1 |
| 20 | Corticosterone promotes increased heme oxygenase- 2 protein transscript expression in the newborn rat显示文摘 | Maines MD Eke BC Zhao X | 1996 | Brain Res1996，722，12： | 1 |
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