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| 1 | 多器官床旁即时超声在新型冠状病毒肺炎中的应用:国际专家共识显示文摘新型冠状病毒肺炎(简称新冠肺炎,COVID-19)自首次报道以来,已造成全球超一亿人感染,给各国的公共卫生体系造成了巨大威胁。新冠肺炎的临床表现以呼吸系统体征和症状为主,80%的患者症状轻微,约5%为危重症患者,常表现为急性呼吸窘迫综合征(ARDS)。前期,由于缺乏相关研究,面对日益紧迫的临床困境,医务人员不得不借鉴采取一些经验性措施以应对疫情。 | 王臻(译) Arif Hussain Gabriele Via Lawrence Melniker Alberto Goffi Guido Tavazzi Luca Neri Tomas Villen Richard Hoppmann Francesco Mojoli Vicki Noble Laurent Zieleskiewicz Pablo Blanco Irene W.Y.Ma Mahathar Abd.Wahab Abdulmohsen Alsaawi Majid AI Salamah Martin Balik Diego Barca Karim Bendjelid Belaid Bouhemad Pablo Bravo-Figueroa Raoul Breitkreutz Juan Calderon Jim Connolly Roberto Copetti Francesco Corradi Anthony J.Dean AndréDenault Deepak Govil Carmela Graci Young-Rock Ha Laura Hurtado Toru Kameda Michael Lanspa Christian B Laursen Francis Lee Rachel Liu Massimiliano Meineri Miguel Montorfano Peiman Nazerian Bret P.Nelson Aleksandar N.Neskovic Ramon Nogue Adi Osman JoséPazeli Elmo Pereira-Junior Tomislav Petrovic Emanuele Pivetta Jan Poelaert Susanna Price Gregor Prosen Shalim Rodriguez Philippe Rola Colin Royse Yale Tung Chen Mike Wells Adrian Wong Wang Xiaoting Wang Zhen Yaseen Arabi | 2021 | 中国呼吸与危重监护杂志2021，20，2： | 5 |
| 2 | Comparison of chemiluminescence enzyme immunoassay based on magnetic microparticles with traditional colorimetric ELISA for the detection of serum α-fetoprotein显示文摘A chemiluminescence enzyme immunoassay based on magnetic microparticles (MmPs-CLEIA) was developed to evaluate serum a-fetoprotein (AFP) in parallel with traditional colorimetric enzyme-linked immunosorbent assay (ELISA).A systematic comparison between the MmPs-CLEIA and colorimetric ELISA concluded that the MPs-CLEIA exhibited fewer dosages of immunoreagents,less total assay time,and better linearity,recovery,precision,sensitivity and validity.AFP was detected in forty human serum samples by the proposed MPs-CLEIA and ELISA,and the results were compared with commercial electrochemiluminescence immunoassay (ECLIA) kit.The correlation coefficient between MPs-CLEIA and ELISA was obtained with R 2 0.6703;however,the correlation between MPs-CLEIA and ECLIA (R 2 0.9582) was obviously better than that between colorimetric ELISA and ECLIA (R 2 0.6866). | Qian-Yun Zhang a,b,Hui Chen a,Zhen Lin a,Jin-Ming Lin a a Beijing Key Laboratory of Microanalytical Methods and Instrumentation,Department of Chemistry,Tsinghua University,Beijing 100029,China b Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China | 2012 | Journal of Pharmaceutical Analysis2012，2，2： | 5 |
| 3 | Zinc protects against cadmium-induced toxicity in neonatal murine engineered cardiac tissues via metallothionein-dependent and independent mechanisms显示文摘Cadmium(Cd)is a nonessential heavy metal and a prevalent environmental toxin that has been shown to induce significant cardiomyocyte apoptosis in neonatal murine engineered cardiac tissues(ECTs).In contrast,zinc(Zn)is a potent metallothionein(MT)inducer,which plays an important role in protection against Cd toxicity.In this study,we investigated the protective effects of Zn against Cd toxicity in ECTs and explore the underlying mechanisms.ECTs were constructed from neonatal ventricular cells of wild-type(WT)mice and mice with global MT gene deletion(MT-KO).In WT-ECTs,Cd(5−20μM)caused a dose-dependent toxicity that was detected within 8 h evidenced by suppressed beating,apoptosis,and LDH release;Zn(50−200μM)dose-dependently induced MT expression in ECTs without causing ECT toxicity;co-treatment of ECT with Zn(50µM)prevented Cd-induced toxicity.In MT-KO ECTs,Cd toxicity was enhanced;but unexpectedly,cotreatment with Zn provided partial protection against Cd toxicity.Furthermore,Cd,but not Zn,significantly activated Nrf2 and its downstream targets,including HO-1;inhibition of HO-1 by a specific HO-1 inhibitor,ZnPP(10µM),significantly increased Cd-induced toxicity,but did not inhibit Zn protection against Cd injury,suggesting that Nrf2-mediated HO-1 activation was not required for Zn protective effect.Finally,the ability of Zn to reduce Cd uptake provided an additional MT-independent mechanism for reducing Cd toxicity.Thus,Zn exerts protective effects against Cd toxicity for murine ECTs that are partially MT-mediated.Further studies are required to translate thesefindings towards clinical trials. | Hai-tao Yu Juan Zhen Jian-xiang Xu Lu Cai Ji-yan Leng Hong-lei Ji Bradley B Keller | 2020 | Acta Pharmacologica Sinica2020，41，5： | 3 |
| 4 | Nanoscopy reveals surface-metallic black phosphorus显示文摘Black phosphorus(BP)is an emerging two-dimensional material with intriguing physical properties.It is highly anisotropic and highly tunable by means of both the number of monolayers and surface doping.Here,we experimentally investigate and theoretically interpret the near-field properties of a-few-atomic-monolayer nanoflakes of BP.We discover near-field patterns of bright outside fringes and a high surface polarizability of nanofilm BP consistent with its surface-metallic,plasmonic behavior at mid-infrared frequencies o1176 cm−1.We conclude that these fringes are caused by the formation of a highly polarizable layer at the BP surface.This layer has a thickness of~1 nm and exhibits plasmonic behavior.We estimate that it contains free carriers in a concentration of n≈1.1×10^(20) cm^(−3).Surface plasmonic behavior is observed for 10–40 nm BP thicknesses but absent for a 4-nm BP thickness.This discovery opens up a new field of research and potential applications in nanoelectronics,plasmonics and optoelectronics. | Yohannes Abate Sampath Gamage Zhen Li Viktoriia Babicheva Mohammad H Javani Han Wang Stephen B Cronin Mark I Stockman | 2016 | Light(Science & Applications)2016，5，1： | 2 |
| 5 | Laser patterning for the study of MSC cardiogenic differentiation at the single-cell level显示文摘Mesenchymal stem cells(MSCs)have been cited as contributors to heart repair through cardiogenic differentiation and multiple cellular interactions,including the paracrine effect,cell fusion,and mechanical and electrical couplings.Due to heart–muscle complexity,progress in the development of knowledge concerning the role of MSCs in cardiac repair is heavily based on MSC–cardiomyocyte coculture.In conventional coculture systems,however,the in vivo cardiac muscle structure,in which rod-shaped cells are connected end-to-end,is not sustained;instead,irregularly shaped cells spread randomly,resulting in randomly distributed cell junctions.Consequently,contact-mediated cell–cell interactions(e.g.,the electrical triggering signal and the mechanical contraction wave that propagate through MSC–cardiomyocyte junctions)occur randomly.Thus,the data generated on the beneficial effects of MSCs may be irrelevant to in vivo biological processes.In this study,we explored whether cardiomyocyte alignment,the most important phenotype,is relevant to stem cell cardiogenic differentiation.Here,we report(i)the construction of a laser-patterned,biochip-based,stem cell–cardiomyocyte coculture model with controlled cell alignment;and(ii)single-cell-level data on stem cell cardiogenic differentiation under in vivo-like cardiomyocyte alignment conditions. | Zhen Ma Qiuying Liu Huaxiao Yang Raymond B Runyan Carol A Eisenberg Meifeng Xu Thomas K Borg Roger Markwald Yifei Wang Bruce Z Gao | 2013 | Light(Science & Applications)2013，2，1： | 2 |
| 6 | Development of an LC-MALDI method for the analysis of protein complexes 显示文摘 | ZHEN Y RICHARDSON B RICHARDSON | 2004 | J Am Soc Mass Spectrom2004，15，6： | 1 |
| 7 | Study on in-situ synthesis of konjac glucomannan/silver nanocomposites via photochemical reduction显示文摘 | Tian D T Hu W B Zhen Z | 2006 | J Ap- pl Polym Sci2006，100，2： | 1 |
| 8 | Production of dimethylfuran for liquid fuels from biomass-derived carbohydrates显示文摘 | Yuriy R L Christopher J B Zhen Y L | 2007 | Nature2007，447，： | 1 |
| 9 | Effect of melt homogeniza- tion temperature on the cast structures of IN 738 LC superalloy 显示文摘 | Liu L Zhen B L Banerji A | 1994 | Scripta Metallurgica Et Materialia1994，30，5： | 1 |
| 10 | Induction of apoptosis by enediyne anti-tumor antibiotic C-1027 in HL60 human promyelocytic leukemiacells 显示文摘 | Jiang B Li DD Zhen YS | 1995 | Biochem Biophys Res Commun1995，8208，1： | 1 |
| 11 | On the mechanics of the grinding process,part Ⅰ: stochastic nature of the grinding proeess显示文摘 | Zhen B H Komanduri R | 2003 | International Journal of Mac- hine Tools & Manufacture2003，43，15： | 1 |
| 12 | The Effect of Pre-aging on Microstructure and Tensile Properties of Al-Mg-Si Alloys 显示文摘 | ZHEN L KANG S B KIM H W | 1997 | Mater Sci & Tech1997，13，： | 1 |
| 13 | The effects of isoflurane and desflurane on cognitive fimction in humans显示文摘 | Zhang B Tian M Zhen Y | 2012 | Anesth Analg2012，114，2： | 1 |
| 14 | Recurrence of the world' s largest green-tide in 2009 in Yellow Sea, China: porphyra yezoensis aquaculture rafts confirmed as nusery for macoralgal blooms 显示文摘 | Liu D Y Keesign J K Dong Z J Zhen Y Di B P Shi Y J Fearns P Shi P | 2011 | Marine Pollution Bulletin2011，60，9： | 1 |
| 15 | SIK2 is a centrosome kinase re- quired for bipolar mitotic spindle formation that provides a po- tential target for therapy in ovarian cancer 显示文摘 | Ashour A Zhen L Nicholas B | 2010 | Cancer Cell2010，18，2： | 1 |
| 16 | The effects of isoflurane and desflurane on cognitive function in humans显示文摘 | ZHANG B TIAN M ZHEN Y | 2012 | Anesth Analg2012，114，2： | 1 |
| 17 | Enhancement effect of Illumination on the photoluminescenee of water-soluble CdTe nanocrystals: toward highly fluorescent CdTe/ CAS core-shell structure显示文摘 | Hao B Yan J G Zhen L | 2004 | J Chem Mater2004，16，20： | 1 |
| 18 | Fe3O4/Au core/shell nanoparticles modified with Ni 2+-nitrilotriacetic acid specific to histidine-tagged proteins显示文摘 | XIE H Y ZHEN R WANG B | 2010 | J Phys Chem C2010，114，11： | 1 |
| 19 | Action potentials drive body wall muscle contractions in Caenorhabditis elegans显示文摘 | GAO S B ZHEN M | 2011 | Proc Natl Acad Sci USA2011，108，6： | 1 |
| 20 | The rise of the intemet city in China: Production and consumption of intemet information显示文摘 | F Zhen B Wang Z Wei | 2014 | Urban Studies2014，52，13： | 1 |
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