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| 1 | High entropy defective fluorite structured rare-earth niobates and tantalates for thermal barrier applications显示文摘Rare-earth tantalates and niobates(REjTaO7 and REjNbO7)have been considered as promising candidate thermal barrier coating(TBC)materials in next generation gas-turbine engines due to their ultra-low thermal conductivity and better thermal stability than yttria-stabilized zirconia(YSZ).However,the low Vickers hardness and toughness are the main shortcomings of RE;TaO-and REjNbOr that limit their applications as TBC materials.To increase the hardness,high entropy(Yu3Ybu3Er/3)sTaOr,(Y13YbnErns)NbO,and(Sm1/6Eu1/6Y 1/6Yb1/6Lu1/6Er1/6)3(Nb1/2Ta1/2)O7 are designed and synthesized in this study.These high entropy ceramics exhibit high Vickers hardness(10.912.0 GPa),close thermal expansion coefficients to that of single-principal-component RE3TaO,and RE;NbO,(7.9×10^-6-10.8×10-6 C-1 at room temperature),good phase stability,and good chemical compatibility with thermally grown Al2O3,which make them promising for applications as candidate TBC materials. | Zifan ZHAO Heng CHEN Huimin XIANG Fu-Zhi DAI Xiaohui WANG Wei XU Kuang SUN Zhjjian PENG Yanchun ZHOU | 2020 | Journal of Advanced Ceramics2020，9，3： | 27 |
| 2 | (La0.2Ce0.2Nd0.2Sm0.2Eu0.2)2Zr2O7:A novel high-entropy ceramic with low thermal conductivity and sluggish grain growth rate显示文摘Fine grains and slow grain growth rate are beneficial to preventing the thermal stress-induced cracking and thermal conductivity increase of thermal barrier coatings.Inspired by the sluggish diffusion effect of high-entropy materials,a novel high-entropy(HE)rare-earth zirconate solid solution(La0.2Ce0.2Nd0.2Sm0.2Eu0.2)2 Zr2 O7 was designed and successfully synthesized in this work.The as-synthesized(La0.2Ce0.2Nd0.2Sm0.2Eu0.2)2 Zr2 O7 is phase-pure with homogeneous rare-earth element distribution.The thermal conductivity of as-synthesized(La0.2Ce0.2Nd0.2Sm0.2Eu0.2)2 Zr2 O7 at room temperature is as low as 0.76 W m^-1 K^-1.Moreover,after being heated at 1500℃for 1-18 h,the average grain size of(La0.2Ce0.2Nd0.2Sm0.2Eu0.2)2 Zr2 O7 only increases from 1.69μm to 3.92μm,while the average grain size of La2Zr2O7 increases from 1.96μm to 8.89μm.Low thermal conductivity and sluggish grain growth rate indicate that high-entropy(La0.2Ce0.2Nd0.2Sm0.2Eu0.2)2Zr2O7 is suitable for application as a thermal barrier coating material and it may possess good thermal stress-induced cracking resistance. | Zifan Zhao Huimin Xiang Fu-Zhi Dai Zhijian Peng Yanchun Zhou | 2019 | Journal of Materials Science & Technology2019，35，11： | 25 |
| 3 | (La0.2Ce0.2Nd0.2Sm0.2Eu0.2)PO4: A high-entropy rare-earth phosphate monazite ceramic with low thermal conductivity and good compatibility with Al2O3显示文摘Low thermal conductivity, matched thermal expansion coefficient and good compatibility are general requirements for the environmental/thermal barrier coatings(EBCs/TBCs) and interphases for Al2O3 f/Al2O3 composites. In this work, a novel high-entropy(HE) rare-earth phosphate monazite ceramic (La0.2Ce0.2Nd0.2Sm0.2Eu0.2)PO4 is designed and successfully synthesized. This new type of HE rare-earth phosphate monazite exhibits good chemical compatibility with Al2O3, without reaction with Al2O3 as high as 1600℃ in air. Moreover, the thermal expansion coefficient(TEC) of HE (La0.2Ce0.2Nd0.2Sm0.2Eu0.2)PO4(8.9 × 10^-6/℃ at 300–1000℃) is close to that of Al2O3. The thermal conductivity of HE (La0.2Ce0.2Nd0.2Sm0.2Eu0.2)PO4 at room temperature is as low as 2.08 W·m^-1·K^-1, which is about 42% lower than that of La PO4. Good chemical compatibility, close TEC to that of Al2O3, and low thermal conductivity indicate that HE (La0.2Ce0.2Nd0.2Sm0.2Eu0.2)PO4 is suitable as a candidate EBC/TBC material and an interphase for Al2O3 f/Al2O3 composites. | Zifan Zhao Heng Chen Huimin Xiang Fu-Zhi Dai Xiaohui Wang Zhijian Peng Yanchun Zhou | 2019 | Journal of Materials Science & Technology2019，35，12： | 15 |
| 4 | High entropy(Y0.2Yb0.2Lu0.2Eu0.2Er0.2)3Al5O12:A novel high temperature stable thermal barrier material显示文摘Ytterbium aluminum garnet(Yb3Al5O12)is considered as a promising thermal barrier material.However,the main limitations of Yb3Al5O12 for thermal barrier applications are relative low thermal expansion coefficient and high thermal conductivity.In order to overcome these obstacles,herein,a new high entropy(Y0.2Yb0.2Lu0.2Eu0.2Er0.2)3Al5O12 ceramic was designed,and then powders and bulk were prepared through solid-state reaction method and spark plasma sintering(SPS),respectively.The thermal expansion coefficient of HE(Y0.2Yb0.2Lu0.2Eu0.2Er0.2)3Al5O12 is(8.54±0.29)×10^-6 K^-1 at 673 K–1273 K,which is about 9%higher than that of Yb3Al5O12.The thermal conductivity of HE(Y0.2Yb0.2Lu0.2Eu0.2Er0.2)3Al5O12 ceramic is 3.81 W·m^-1 K^-1 at 300 K,which is about 18%lower than that of Yb3Al5O12.Moreover,there is no reaction between HE(Y0.2Yb0.2Lu0.2Eu0.2Er0.2)3Al5O12 and thermally grown(TG)Al2O3 even at 1600℃.After annealing at 1590℃for 18 h,the average grain size of HE(Y0.2Yb0.2Lu0.2Eu0.2Er0.2)3Al5O12 increases only from 1.56μm to 2.27μm.Close thermal expansion coefficient to TG Al2O3,low thermal conductivity,good phase stability,excellent chemical compatibility with TG Al2O3 and slow grain growth rate make HE(Y0.2Yb0.2Lu0.2Eu0.2Er0.2)3Al5O12 promising for thermal barrier applications. | Heng Chen Zifan Zhao Huimin Xiang Fu-Zhi Dai Wei Xu Kuang Sun Jiachen Liu Yanchun Zhou | 2020 | Journal of Materials Science & Technology2020，47，13： | 14 |
| 5 | High-entropy(Nd_(0.2)Sm_(0.2)Eu_(0.2)Y_(0.2)Yb_(0.2))_(4)Al_(2)O_(9) with good high temperature stability,low thermal conductivity,and anisotropic thermal expansivity显示文摘The critical requirements for the environmental barrier coating(EBC)materials of silicon-based ceramic matrix composites(CMCs)include good tolerance to harsh environments,thermal expansion matches with the interlayer mullite,good high-temperature phase stability,and low thermal conductivity.Cuspidine-structured rare-earth aluminates RE_(4)Al_(2)O_(9) have been considered as candidates of EBCs for their superior mechanical and thermal properties,but the phase transition at high temperatures is a notable drawback of these materials.To suppress the phase transition and improve the phase stability,a novel cuspidine-structured rare-earth aluminate solid solution(Nd_(0.2)Sm_(0.2)Eu_(0.2)Y_(0.2)Yb_(0.2))_(4)Al_(2)O_(9) was designed and successfully synthesized inspired by entropy stabilization effect of high-entropy ceramics(HECs).The as-synthesized HE(Nd_(0.2)Sm_(0.2)Eu_(0.2)Y_(0.2)Yb_(0.2))_(4)Al_(2)O_(9) exhibits a close thermal expansion coefficient(6.96×10^(-6) K^(-1) at 300-1473 K)to that of mullite,good phase stability from 300 to 1473 K,and low thermal conductivity(1.50 W·m^(-1)·K^(-1) at room temperature).In addition,strong anisotropic thermal expansion has been observed compared to Y_(4)Al_(2)O_(9) and Yb_(4)Al_(2)O_(9).The mechanism for low thermal conductivity is attributed to the lattice distortion and mass difference of the constituent atoms,and the anisotropic thermal expansion is due to the anisotropic chemical bonding enhanced by the large size rare-earth cations. | Zifan ZHAO Huimin XIANG Heng CHEN Fu-Zhi DAI Xiaohui WANG Zhijian PENG Yanchun ZHOU | 2020 | Journal of Advanced Ceramics2020，9，5： | 12 |
| 6 | Highly efficient and stable white LEDs based on pure red narrow bandwidth emission triangular carbon quantum dots for wide-color gamut backlight displays显示文摘High-performance white light-emitting diodes (WLEDs) hold great potential for the next-generation backlight display applications.However,achieving highly efficient and stable WLEDs with wide-color-gamut has remained a formidable goal.Reported here is the first example of pure red narrow bandwidth emission triangular CQDs (PR-NBE-T-CQDs) with photoluminescence peaking at 610 nm.The PR-NBE-T-CQDs synthesized from resorcinol show high quantum yield (QY) of 72% with small full width at half maximum of 33 nm.By simply controlling the reaction time,pure green (PG-) NBE-T-CQDs with high QY of 75% were also obtained.Highly efficient and stable WLEDs with wide-color-gamut based on PR- and PG-NBE-T-CQDs was achieved.This WLED showed a remarkable wide-color gamut of 110% NTSC and high power efficiency of 86.5 lumens per Watt.Furthermore,such WLEDs demonstrate outstanding stability.This work will set the stage for developing highly efficient,low cost and environment-friendly WLEDs based on CQDs for the next-generation wide-color gamut backlight displays. | Fanglong Yuan Ping He Zifan Xi Xiaohong Li Yunchao Li Haizheng Zhong Louzhen Fan Shihe Yang | 2019 | Nano Research2019，12，7： | 12 |
| 7 | (TiZrHf)P2O7: An equimolar multicomponent or high entropy ceramic with good thermal stability and low thermal conductivity显示文摘Zr P2O7 is a promising material for high temperature insulating applications. However, decomposition above 1400℃ is the bottleneck that limiting its application at high temperatures. To improve the thermal stability, a novel multicomponent equimolar solid solution(Ti Zr Hf)P2O7 was designed and successfully synthesized in this work inspired by high-entropy ceramic(HEC) concept. The as-synthesized(Ti Zr Hf)P2O7 exhibits good thermal stability, which is not decomposed after heating at 1550℃ for 3 h. It also shows lower thermal conductivity(0.78 W m^-1 K^-1) compared to the constituting metal pyrophosphates Ti P2O7, Zr P2O7 and Hf P2O7. The combination of high thermal stability and low thermal conductivity renders(Ti Zr Hf)P2O7 promising for high temperature thermal insulating applications. | Zifan Zhao Huimin Xiang Fu-Zhi Dai Zhijian Peng Yanchun Zhou | 2019 | Journal of Materials Science & Technology2019，35，10： | 12 |
| 8 | Achieving strong microwave absorption capability and wide absorption bandwidth through a combination of high entropy rare earth silicide carbides/rare earth oxides显示文摘Developing electromagnetic(EM) wave absorbing materials with low reflection coefficient and optimal operating frequency band is urgently needed on account of the increasingly serious EM pollution. However, the applications of common EM absorbing materials are encumbered by poor high-temperature stability, poor oxidation resistance, narrow absorption bandwidth or high density. Herein, the strong EM absorption capability and wide efficient absorption bandwidth of high entropy ceramics are reported for the first time, which are designed by a combination of the novel high entropy(HE) rare earth silicide carbides/rare earth oxides(RE3 Si2 C2/RE2 O3). Three HE powders, i.e., HERSC-1(HE(Tm0.2 Y0.2 Dy0.2 Gd0.2 Tb0.2)3 Si2 C2),HERSC-2 HE(Tm0.2 Y0.2 Dy0.2 Gd0.2 Tb0.2)3 Si2 C2/HE(Tm0.2 Y0.2 Dy0.2 Gd0.2 Tb0.2)2 O3) and HERSC-3(HE(Tm0.2 Y0.2 Dy0.2 Gd0.2 Tb0.2)3 Si2 C2/HE(Tm0.2 Y0.2 Dy0.2 Gd0.2 Tb0.2)2 O3), are synthesized. Although HERSC-1 exhibits a limited absorption effect(the minimum reflection loss(RLmin) is-11.6 d B at 3.4 mm) and a relatively narrow effective absorption bandwidth(EAB) of 1.7 GHz, the optimal absorption RLminvalue and EAB of HERSC-2 and HERSC-3 are-40.7 d B(at 2.9 mm), 3.4 GHz and-50.9 d B(at 2.0 mm), 4.5 GHz,respectively, demonstrating strong microwave absorption capability and wide absorption bandwidth.Considering the better stability, low density and strong EM absorption effect, HE ceramics are promising as a new type of EM absorbing materials. | Heng Chen Biao Zhao Zifan Zhao Huimin Xiang Fu-Zhi Dai Jiachen Liu Yanchun Zhou | 2020 | Journal of Materials Science & Technology2020，47，12： | 12 |
| 9 | Generation of a Hutchinson-Gilford progeria syndrome monkey model by base editing显示文摘Many human genetic diseases,including Hutchinson-Gilford progeria syndrome(HGPS),are caused by single point mutations.HGPS is a rare disorder that causes premature aging and is usually caused by a de novo point mutation in the LMNA gene.Base editors(BEs)composed of a cytidine deaminase fused to CRISPR/Cas9 nickase are highly efficient at inducing C to T base conversions in a programmable manner and can be used to generate animal disease models with single amino-acid substitutions.Here,we generated the first HGPS monkey model by delivering a BE mRNA and guide RNA(gRNA)targeting the LMNA gene via microinjection into monkey zygotes.Five out of six newborn monkeys carried the mutation specifically at the target site.HGPS monkeys expressed the toxic form of lamin A,progerin,and recapitulated the typical HGPS phenotypes including growth retardation,bone alterations,and vascular abnormalities.Thus,this monkey model genetically and clinically mimics HGPS in humans,demonstrating that the BE system can efficiently and accurately generate patient-specific disease models in non-human primates. | Fang Wang Weiqi Zhang Qiaoyan Yang Yu Kang Yanling Fan Jingkuan Wei Zunpeng Liu Shaoxing Dai Hao Li Zifan Li Lizhu Xu Chu Chu Jing Qu Chenyang Si Weizhi Ji Guang-Hui Liu Chengzu Long Yuyu Niu | 2020 | Protein & Cell2020，11，11： | 11 |
| 10 | High-entropy(Y0.2Nd0.2Sm0.2Eu0.2Er0.2)AlO3:A promising thermal/environmental barrier material for oxide/oxide composites显示文摘Yttrium aluminum perovskite(YAl O3)is a promising candidate material for environmental barrier coatings(EBCs)to protect Al2 O3 f/Al2 O3 ceramic matrix composites(CMCs)from the corrosion of high-temperature water vapor in combustion environments.Nevertheless,the relatively high thermal conductivity is a notable drawback of YAl O3 for environmental barrier coating application.Herein,in order to make REAl O3 more thermal insulating,a novel high-entropy rare-earth aluminate ceramic(Y0.2Nd0.2Sm0.2Eu0.2Er0.2)AlO3 was designed and synthesized.The as-prepared(Y0.2Nd0.2Sm0.2Eu0.2Er0.2)AlO3 ceramic possesses close thermal expansion coefficient(9.02×10-6/oC measured from room temperature to 1200℃)to that of Al2 O3.The thermal conductivity of(Y0.2Nd0.2Sm0.2Eu0.2Er0.2)AlO3 at room temperature is 4.1 W·m-1K-1,which is almost one third of the value of YAl O3.Furthermore,to effectively prevent the penetration of water vapor from possible pores/cracks of coating layer,which are often observed in T/EBCs,a tri-layer EBC system REAl O3/RE3 Al5 O12/(Al2 O3 f/Al2 O3 CMCs)is designed.Close thermal expansion coefficient to Al2 O3 and low thermal conductivity of(Y0.2Nd0.2Sm0.2Eu0.2Er0.2)AlO3,as well as the formation of dense garnet layer at(Y0.2Nd0.2Sm0.2Eu0.2Er0.2)AlO3/Al2 O3 interface,indicate that this new type of high-entropy ceramic is suitable as a candidate environmental barrier coating material for Al2 O3 f/Al2 O3 CMCs. | Zifan Zhao Heng Chen Huimin Xiang Fu-Zhi Dai Xiaohui Wang Wei Xu Kuang Sun Zhijian Peng Yanchun Zhou | 2020 | Journal of Materials Science & Technology2020，47，12： | 9 |
| 11 | Distributed Scheduling Problems in Intelligent Manufacturing Systems显示文摘Currently,manufacturing enterprises face increasingly fierce market competition due to the various demands of customers and the rapid development of economic globalization.Hence,they have to extend their production mode into distributed environments and establish multiple factories in various geographical locations.Nowadays,distributed manufacturing systems have been widely adopted in industrial production processes.In recent years,many studies have been done on the modeling and optimization of distributed scheduling problems.This work provides a literature review on distributed scheduling problems in intelligent manufacturing systems.By summarizing and evaluating existing studies on distributed scheduling problems,we analyze the achievements and current research status in this field and discuss ongoing studies.Insights regarding prior works are discussed to uncover future research directions,particularly swarm intelligence and evolutionary algorithms,which are used for managing distributed scheduling problems in manufacturing systems.This work focuses on journal papers discovered using Google Scholar.After reviewing the papers,in this work,we discuss the research trends of distributed scheduling problems and point out some directions for future studies. | Yaping Fu Yushuang Hou Zifan Wang Xinwei Wu Kaizhou Gao Ling Wang | 2021 | Tsinghua Science and Technology2021，26，5： | 9 |
| 12 | Interaction of Restin with transcription factors显示文摘Restin, a member of melanoma-associated antigen superfamily gene, was first cloned from differentiated leukemia cell induced by all trans-retinoic acid, and was able to inhibit cell proliferation, but the molecular mechanism was not clear. Since Restin was localized in cell nucleus, and its homolog member, Necdin (neuronal growth suppressor factor), could interact with transcription factors p53 and E2F1, we proposed that Restin might also function as Necdin through interacting with some transcription factors. In this study, transcription factors p53, AP1, ATFs and E2Fs were cloned and used in the mammalian two-hybrid system to identify their in- teraction with Restin. The results showed that only ATF3 had a strong interaction with Restin. It is interesting to know that ATF3 was an important transcription factor for G1 cell cycle initiation in physiological stress response. It was possible that the inhibition of cell proliferation by Restin might be related with the inhibition of ATF3 activity. | WU Yousheng LU Fan QI Yinxin WANG Ruihua ZHANG Jian LU Zifan ZHAO Zhongliang | 2005 | Science China(Life Sciences)2005，48，3： | 5 |
| 13 | Erratum to:Highly efficient and stable white LEDs based on pure red narrow bandwidth emission triangular carbon quantum dots for wide-color gamut backlight displays显示文摘In the version of this article originally published,Figs.2(d)and 3(a),and Figs.S3 and S6 in the Electronic Supplementary Material(ESM)were incorrect.The corrected images are shown below. | Fanglong Yuan Ping He Zifan Xi Xiaohong Li Yunchao Li Haizheng Zhong Louzhen Fan Shihe Yang | 2020 | Nano Research2020，13，8： | 2 |
| 14 | Synergy of photocatalytic reduction and adsorption for boosting uranium removal with PMo_(12)/UiO-66 heterojunction显示文摘In this work,we proposed a new U(Ⅵ)removal strategy combining adsorption and photocatalytic reduction by the PMo_(12)/UiO-66 heterojunctions.The PMo_(12)has been encapsulated in the cavities of Ui O-66 by a one-step hydrothermal method,and the PMo_(12)/UiO-66 exhibited high adsorption capacity and photocatalytic activity.The maximal theoretical sorption capacity of U(Ⅵ)on 15%PMo_(12)/UiO-66 reached225.36 mg/g and the photoreduction rate of 15%PMo_(12)/UiO-66 is about thirty times as much as UiO-66.Under the light irradiation,the photogenerated electrons rapidly transport from UiO-66 to PMo_(12),and the photo-generated electrons could efficiently reduce the pre-enriched U(Ⅵ)to U(IV).This work provides new insights into remediation of the radioactive environment. | Zhibin Zhang Zifan Li Zhimin Dong Fengtao Yu Yingcai Wang Youqun Wang Xiaohong Cao Yuhui Liu Yunhai Liu | 2022 | Chinese Chemical Letters2022，33，7： | 2 |
| 15 | RNA-binding protein QKI regulates contact inhibition via Yes-associate protein in ccRCC显示文摘Contact inhibition adjusts organ size to the proper size and ensures the cultured cells growing to a monolayer.By regulating the downstream coordinator YAP,the evolutionarily conserved Hippo transduction pathway attunes cell growth and death in response to cell contact inhibition,polarity,self-renewal,and differentiation.Dysregulation of this pathway is involved in various diseases such as cancer.RNA-binding protein QKI regulates cell proliferation,metabolism,division,and immunity in various cancer models,but its role in cancer cell contact inhibition remains unclear.In this study,we aimed to clarify the relationship between QKI and YAP,and the role of their interaction in cell contact inhibition.We found a lower QKI expression level in sparse condition,whereas a higher expression level in confluent condition by western blot analysis and immunofluorescence assay.QKI knockdown elevated cell proliferation and invasion both in vitro and in vivo.Strikingly,the results of CCK-8 assay,colony formation assay,and transwell assay showed that the phenomenon was in accord with the expression level of pYAP and reverse with YAP.Higher levels of Wnt3a and β-catenin were also found in xenografts of QKI-knockdown clear cell renal cell carcinoma (ccRCC) CAKI-1 cells by western blot analysis and immumohistochemical staining.Finally,a positive correlation between QKI and pYAP was found in clinical specimens by immunohistochemistry.Thus,as a negative regulator of YAP,QKI attuned the cell contact inhibition,leading to inhibition of cancer cell proliferation and invasion through Wnt and GPCR pathway. | Zheng Zhu Di Wei Xi'an Li Fuli Wang Fei Yan Zibao Xing Zhao Yan Huanyu Lu Dongsheng Zhai Ziehen Ye Geng Zhang Ping Meng Yu Zheng Jiarui Yuan Zifan Lu Jianlin Yuan | 2019 | Acta Biochimica et Biophysica Sinica2019，51，1： | 2 |
| 16 | Trends in Chemical Composition of Precipitation in Nanjing China, during 1992- 2003 显示文摘 | Jun Tu Hesheng Wang Zifan Zhang | 2005 | Atmospheric Research2005，73，34： | 1 |
| 17 | Clincal characterization of gastroenteritis-related seizure in children,impact of fever and serum sodlium levels显示文摘 | Zifan E Alehan F Menascu S | 2011 | J Child Neurol2011，26，11： | 1 |
| 18 | Noise in nanopore sensors: Sources, models, reduction, and benchmarking显示文摘Label-free nanopore sensors have emerged as a new generation technology of DNA sequencing and have been widely used for single molecule analysis.Since the firstα-hemolysin biological nanopore,various types of nanopores made of different materials have been under extensive development.Noise represents a common challenge among all types of nanopore sensors.The nanopore noise can be decomposed into four components in the frequency domain(1/f noise,white noise,dielectric noise,and amplifier noise).In this work,we reviewed and summarized the physicalmodels,origins,and reduction methods for each of these noise components.For the first time,we quantitatively benchmarked the root mean square(RMS)noise levels for different types of nanopores,demonstrating a clear material-dependent RMS noise.We anticipate this review article will enhance the understanding of nanopore sensor noises and provide an informative tutorial for developing future nanopore sensors with a high signal-to-noise ratio. | Shengfa Liang Feibin Xiang Zifan Tang Reza Nouri Xiaodong He Ming Dong Weihua Guan | 2020 | Nanotechnology and Precision Engineering2020，3，1： | 1 |
| 19 | Manipulations of micro/nanoparticles using gigahertz acoustic streaming tweezers显示文摘Contactless acoustic manipulation of micro/nanoscale particles has attracted considerable attention owing to its near independence of the physical and chemical properties of the targets,making it universally applicable to almost all biological systems.Thin-film bulk acoustic wave(BAW)resonators operating at gigahertz(GHz)frequencies have been demonstrated to generate localized high-speed microvortices through acoustic streaming effects.Benefitting from the strong drag forces of the high-speed vortices,BAW-enabled GHz acoustic streaming tweezers(AST)have been applied to the trapping and enrichment of particles ranging in size from micrometers to less than 100 nm.However,the behavior of particles in such 3D microvortex systems is still largely unknown.In this work,the particle behavior(trapping,enrichment,and separation)in GHz AST is studied by theoretical analyses,3D simulations,and microparticle tracking experiments.It is found that the particle motion in the vortices is determined mainly by the balance between the acoustic streaming drag force and the acoustic radiation force.This work can provide basic design principles for AST-based lab-on-a-chip systems for a variety of applications. | Hang Wu Zifan Tang Rui You Shuting Pan Wenpeng Liu Hongxiang Zhang Tiechuan Li Yang Yang Chongling Sun Wei Pang Xuexin Duan | 2022 | Nanotechnology and Precision Engineering2022，5，2： | 1 |
| 20 | Pathogenesis of premature coronary artery disease:Focus on risk factors and genetic variants显示文摘The development of premature coronary artery disease(PCAD)is dependent on both genetic predisposition and traditional risk factors.Strategies for unraveling the genetic basis of PCAD have evolved with the advent of modern technologies.Genome-wide association studies(GWASs)have identified a considerable number of common genetic variants that are associated with PCAD.Most of these genetic variants are attributable to lipid and blood pressure-related single-nucleotide polymorphisms(SNPs).The genetic variants that predispose individuals to developing PCAD may depend on race and ethnicity.Some characteristic genetic variants have been identified in Chinese populations.Although translating this genetic knowledge into clinical applications is still challenging,these genetic variants can be used for CAD phenotype identification,genetic prediction and therapy.In this article we will provide a comprehensive review of genetic variants detected by GWASs that are predicted to contribute to the development of PCAD.We will highlight recent findings regarding CAD-related genetic variants in Chinese populations and discuss the potential clinical utility of genetic variants for preventing and managing PCAD. | Haiming Wang Zifan Liu Junjie Shao Min Jiang Xuechun Lu Lejian Lin Lin Wang Qiang Xu Haomin Zhang Xin Li Jingjing Zhou Yundai Chen Ran Zhang | 2022 | Genes & Diseases2022，9，2： | 1 |
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