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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Under-film corrosion of epoxy-coated galvanised steel An EIS and SVET study of the effect of inhibition at defects显示文摘 | Zin I M Lyon S B Hussain A | 2005 | Progress in Organic Coatings2005，，52： | 1 |
| 3 | Informal Caregiving and Self-reported Mental and Physical Health:Results from the Gazel Cohort Study 显示文摘 | Buyck J F Bonnaud S Boumendil A Andrieu S Bonenfant S Goldberg M Zins M and Ankri J | 2011 | American Journal of Public Health2011，101，： | 1 |
| 4 | A simple method for assessing the validity of the esophageal balloon technique 显示文摘 | Baydur A Behrakis PK Zin WA | 1982 | Am Rev Respir Dis1982，126，5： | 1 |
| 5 | Anxiety or depressive disorders and risk of ischaemic heart disease among French power company employees显示文摘 | Allonier C Chevalier A Zins M | 2004 | Int J Epidemiol2004，33，4： | 1 |
| 6 | Self-reported outcome after diode laser hair removal显示文摘 | Zins J E Alghoul M Gonzalez A M | 2008 | Ann Plast Surg2008，60，3： | 1 |
| 7 | Assessment of strontium immobilization in cement bentonite matrices 显示文摘 | Abdel Rahman R O Zin El Abidin D H A Abou- Shady H | 2013 | Chem Eng J2013，228，： | 1 |
| 8 | Sintering behaviour of iron-molybdenum steels with the addition of Fe-B-C master alloy powders 显示文摘 | Zin Z Salwen A | 2003 | Powder Metallurgy2003，46，2： | 1 |
| 9 | An overview on doubly fed induction generators' controls and contributions to wind based electricity generation 显示文摘 | Abdullah Asuhaimi B Mohd Zin Mahmoud Pesaran H A Azhar B Khairuddin | 2013 | Renewable and Sustainable Energy Reviews2013，，27： | 1 |
| 10 | Development and Implementation of Neural Network Observers to Estimate Synchronous Generators' Dynamic Parameters Using On-Line Operating Data 显示文摘 | SHARIATI O MOHD ZIN O O KHAIRUDDIN A | 2014 | Electrical Engineering2014，96，1： | 1 |
| 11 | Risk premiums in the term structure: Evidence from artificial economies 显示文摘 | Backus D K Gregory A W Zin S E | 1989 | Journal of Monetary Economics1989，24，3： | 1 |
| 12 | Calcification in focal nodular hyperplasia: A new problem for differentiation from fibrolamellar hepatocellular carcinoma 显示文摘 | Caseiro-Alves F Zins M Mahfouz A E | 1996 | Radiology1996，198，3： | 1 |
| 13 | Plasmonic focusing reduces ensemble linewidth of silver-coated gold nanorods显示文摘 | Becker J Zins I Jakab A | 2008 | Nano Lett2008，8，6： | 1 |
| 14 | The drought characteristics using the first-order homogeneous markov chain of monthly rainfall data in peninsular malaysia显示文摘 | Sanusi W Jemain A Zin W | 2015 | Water Resources Management2015，29，5： | 1 |
| 15 | Multi-focal gliosarcoma: a case report and review of the literature 显示文摘 | Pakosl E Goussia A Zin al V | 2005 | Neuro Oncol2005，74，3： | 1 |
| 16 | Respiratory manifestations of panic disorder: causes, consequences and therapeutic implications 显示文摘 | Sardinha A Freire RC Zin WA | 2009 | J Bras Pneumo12009，35，7： | 1 |
| 17 | Improved CAM shift based on supervised learning 显示文摘 | Zin N A M Abdullah S N H S Abdullah A | 2013 | Robot Intelli- gence Technology and Applications2013，208，： | 1 |
| 18 | Retinopathy of prematurity-incidence today显示文摘 | Zin A Gole GA | 2013 | Clin Perinatol2013，40，2： | 1 |
| 19 | Applying species-sensitivity distributions in ecological risk assessment:Assumptions of distribution type and sufficient numbers of species显示文摘 | Newman M C Ownby D R Mézin L C A | | 0，，02： | 1 |
| 20 | Impact of a preven- tion strategy targeting hand hygiene and catheter care on t he incidence of catheter related bloodstream in fections显示文摘 | Zin gg W Imhof A Maggiorini M etal | 2009 | Crit Care Med2009，37，7： | 1 |
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