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| 1 | Percutaneous coronary intervention in nonagenarians: pros and cons显示文摘Percutaneous coronary intervention is a mainstay in the management of symptomatic or high-risk coronary artery disease. The bulk of clinical evidence and experience underlying this fact relies, however, on relatively young patients. Indeed, few data of very limited quality are available which adequately define the risk-benefit and cost-benefit profile of coronary angioplasty and stenting in very old subjects, such as those of 90 years of age or older (i.e., nonagenarians). The aim of this review is to provide a concise, yet practical, synthesis of the available evidence on percutaneous coronary revascularization in the very elderly. The main arguments elaborated upon are to what extent we can extrapolate findings from studies including younger patients to nonagenarians, whether we should provide higher priority to prognosis or quality of life in such patients, and whether we can afford to allocate vast resources to care for such subjects in an era of financial constraints. Our review of 18 studies and 1082 patients suggest that percutaneous coronary intervention is feasible and associated with acceptable short- and long-term results in this population, which is nonetheless fraught with a high mortality risk irrespective of the revascularization procedure. Accordingly, the pros and cons of percutaneous coronary intervention should be carefully weighed when considering this treatment in nonagenarians. | Giuseppe Biondi Zoccai Antonio Abbate Fabrizio D'Ascenzo Davide Presutti Mariangela Peruzzi Elena Cavarretta Antonino G.M. Marullo Marzia Lotrionte Giacomo Frati | 2013 | Journal of Geriatric Cardiology2013，10，1： | 6 |
| 2 | Late percutaneous coro- nary intervention for the totally occluded infarct - related artery : a me- ta - analysis of the effects on cardiac function and remodeling 显示文摘 | Appleton DL Abbate A Biondi - Zoccai GG | 2008 | Catheter Cardiovasc Interv2008，71，6： | 1 |
| 3 | Radial versus femoral approach for percutaneous coronary diagnostic and interventional procedures; Systematic overview and meta- analysis of randomized trials 显示文摘 | Agostoni P Biondi -Zoccai GG de Benedictis ML | 2004 | J Am Coil Cardiol2004，44，2： | 1 |
| 4 | 'Trans- Collateral' Angio- plasty for a challenging chronic total occlusion of the tibial vessels: a novelapproach to percutaneous revascularization in critical lower limb ischemia 显示文摘 | Fusaro M Agostoni P Biondi- Zoccai G | 2008 | Catheter Cardiovasc Interv2008，71，2： | 1 |
| 5 | Desflurane and sevoflurane in eardiac surgery: a meta - analysis of ran- domized clinical trials 显示文摘 | Landoni G Biondi - Zoccai GGL Zangrillo A | 2007 | Journal of cardiothoracic and vas- cular anesthesia2007，21，4： | 1 |
| 6 | Pedal -plantar loop tech- nique for a challenging below - the - knee chronic total occlusion : a no- vel approach to percutaneous revascularization in critical lower limb is- chemia 显示文摘 | Fusaro M Dalla Paola L Biondi -Zoccai G | 2007 | J Invasive Cardio12007，19，2： | 1 |
| 7 | 'Trans - collateral' angio- plasty for a challenging chronic total occlusion of the tibial vessels : a novel approach to percutaneous revascularization in critical lower limb ischemia 显示文摘 | Fusaro M Agostoni P Biondi - Zoccai G | 2008 | Catheter Cardiovasc Interv2008，71，2： | 1 |
| 8 | A systematic review and meta - analysis on the hazards of discontinuing or not adhering to aspirin among 50,279 patients at risk for coronaryartery disease 显示文摘 | Biondi - Zoccai GG Lotrionte M Agostoni P | 2006 | Eur Heart2006，27，22： | 1 |
| 9 | Atherothrombosis, inflammation, and diabetes显示文摘 | Biondi- Zoccai GG Abbate A Liuzzo G | 2003 | J Am Coll Cardiol2003，41，7： | 1 |
| 10 | Myocardial infarction after percutaneous coronary intervention:a meta-analysis of troponin elevation applying the new universal definition显示文摘 | Testa L Van Gaal WJ Biondi Zoccai GG | 2009 | QJM2009，102，6： | 1 |
| 11 | Atherothrombosis, inflammation, and diabetes显示文摘 | Biondi Zoccai G G Abbate A Liuzzo G | 2003 | J Am Con Cardiot2003，41，7： | 1 |
| 12 | Increased myocardial apoptosis in patients with unfavorable left ventricular remodeling and early symptomatic post-infarction heart failure显示文摘 | Abbate A Giuseppe GL Zoccai B | 2003 | J Am Coll Cardiol2003，41，5： | 1 |
| 13 | Radial versus femoral approach for percutaneous coronary diagnostic and interventional procedures ; Systematic overview and meta - analysis of randomized trials显示文摘 | Agostoni P Biondi -Zoccai GG | 2004 | J Am Coll Cardiol2004，44，2： | 1 |
| 14 | Cyclooxygenase-2(cox- 2 )expression at the site of recent myocardial infa iend or foe显示文摘 | ABBATE A SANTINI D BIONDI ZOCCAI G G | 2004 | Heart2004，90，4： | 1 |
| 15 | Increasedmortality after coronary stenting in patients treated withclopidogrel without loading dose evidence from a meta-a-nalysis显示文摘 | Biondi Zoccai GG Agostoni P Testa L | 2004 | Minerva Cardioangiol2004，52，： | 1 |
| 16 | A systematic review and meta-analysis on the hazards of discontinuing or not adhering to aspirin among 50 279 patients at risk for coronary artery disease显示文摘 | Biondi -Zoccai GG Lotrionte M Agostoni P | 2006 | Eur Heart J2006，27，22： | 1 |
| 17 | Systematic review and meta-analysis of randomized clinical trials appraising the impact of cilostazol after percutaneous coronary intervention显示文摘 | BIONDI ZOCCAI G G LOTRIONTE M ANSELMINO M | 2008 | Am Heart J2008，155，6： | 1 |
| 18 | Late percutaneous coro-nary in tervention for the totally occluded infact-related artery:a meta-analysis of the effects on cardiac function and remodeling显示文摘 | Appleton DL AbbateA Biondi Zoccai GG | 2008 | Catheter Cardiovasc Interv2008，71，77： | 1 |
| 19 | Reducing mortality in car- diac surgery with levosimendan: A meta- analysin of randomized con-trolled trials 显示文摘 | Landoni G Mizzi A Biondi -Zoccai G | 2009 | J Cardiothorac Vasc Anesth2009，24，1： | 1 |
| 20 | Survival and cardi-acrem odeling benefits in patients undergoing late percutaneouscoronary in tervention of the infarct-related artery:evidence from a meta-analysis of randomized controlled trials显示文摘 | Abbate A Biondi Zoccai GG Appleton DL | 2008 | J Am Coll Cardiol2008，51，9： | 1 |
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