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| 1 | Mitochondrial dysfunctions in neurodegenerative diseases:role in disease pathogenesis,strategies for analysis and therapeutic prospects显示文摘Fundamental organelles that occur in every cell type with the exception of mammal erythrocytes,the mitochondria are required for multiple pivotal processes that include the production of biological energy,the biosynthesis of reactive oxygen species,the control of calcium homeostasis,and the triggering of cell death.The disruption of anyone of these processes has been shown to impact strongly the function of all cells,but especially of neurons.In this review,we discuss the role of the mitochondria impairment in the development of the neurodegenerative diseases Amyotrophic Lateral Sclerosis,Parkinson's disease and Alzheimer's disease.We highlight how mitochondria disruption revolves around the processes that underlie the mitochondria's life cycle:fusion,fission,production of reactive oxygen species and energy failure.Both genetic and sporadic forms of neurodegenerative diseases are unavoidably accompanied with and often caused by the dysfunction in one or more of the key mitochondrial processes.Therefore,in order to get in depth insights into their health status in neurodegenerative diseases,we need to focus into innovative strategies aimed at characterizing the various mitochondrial processes.Current techniques include Mitostress,Mitotracker,transmission electron microscopy,oxidative stress assays along with expression measurement of the proteins that maintain the mitochondrial health.We will also discuss a panel of approaches aimed at mitigating the mitochondrial dysfunction.These include canonical drugs,natural compounds,supplements,lifestyle interventions and innovative approaches as mitochondria transplantation and gene therapy.In conclusion,because mitochondria are fundamental organelles necessary for virtually all the cell functions and are severely impaired in neurodegenerative diseases,it is critical to develop novel methods to measure the mitochondrial state,and novel therapeutic strategies aimed at improving their health. | Federica Rey Sara Ottolenghi Gian Vincenzo Zuccotti Michele Samaja Stephana Carelli | 2022 | Neural Regeneration Research2022，17，4： | 3 |
| 2 | Type 1 diabetes and celiac disease:The effects of gluten free diet on metabolic control显示文摘Type 1 diabetes mellitus is associated with celiac disease,with a prevalence that varies between 0.6% and 16.4%,according to different studies.After a diagnosis of celiac disease is confirmed by small bowel biopsy,patients are advised to commence a gluten-free diet(GFD).This dietary restriction may be particularly difficult for the child with diabetes,but in Europe(and in Italy) many food stores have targeted this section of the market with better labeling of products and more availability of specific GFD products.Treatment with a GFD in symptomatic patients has been shown to improve the symptoms,signs and complications of celiac disease.However,the effects of a GFD on diabetic control are less well established.Initial reports of improved hypoglycemic control were based on children who were diagnosed with celiac disease associated with malabsorption,but there have subsequently been reports of improvement in patients with type 1 diabetes with subclinical celiac disease.There are other studies reporting no effect,improved control and an improvement of hypoglycemic episodes.Moreover,in this review we wish to focus on low glycemic index foods,often suggested in people with type 1 diabetes,since they might reduce postprandial glycemic excursion and enhance longterm glycemic control.In contrast,GFD may be rich in high glycemic index foods that can increase the risk of obesity,insulin resistance and cardiovascular disease,worsening the metabolic control of the child with diabetes.Hence,it is important to evaluate the impact of a GFD on metabolic control,growth and nutritional status in children with type 1 diabetes. | Andrea E Scaramuzza Cecilia Mantegazza Alessandra Bosetti Gian Vincenzo Zuccotti | 2013 | World Journal of Diabetes2013，4，4： | 2 |
| 3 | Full- term development of mice from nucleared oocyte injected with cumulus cell nuclei 显示文摘 | WAKAYMA T PERRY A C ZUCCOTTI M | 1998 | Nature1998，394，： | 1 |
| 4 | Full-term development of mice from nucleared oocyte injected with cumulus cell nuclei显示文摘 | WAKAYAMA T PERRY A C ZUCCOTTI M | 1998 | Nature1998，394，： | 1 |
| 5 | Full-term development of mice from enucleated oocytes injected with cumulus cell nuelei显示文摘 | Wakayama T Perry A C Zuccotti M | 1998 | Nature1998，394，： | 1 |
| 6 | Fullterm development of mice from enucleated oocytes injected with cumulus cell nuclei显示文摘 | Wakayam T Perry AC zuccotti M | 1998 | Nature1998，394，： | 1 |
| 7 | Full-term development of mice from nucleared oocyte injected with cumulus cell nuclei显示文摘 | Wakayama T Perry A C Zuccotti M | 1998 | Nature1998，394，： | 1 |
| 8 | Docosahexaenoic acid supplementation and time at achievement of gross motor mile stones in healthy infants: a randomized, prospective, double-blind, placebo-controlled trial 显示文摘 | Agostoni C Zuccotti GV Radaelli G | 2009 | Am J Clin Nutr2009，89，1： | 1 |
| 9 | The analysis of chromatin organisation allows selection of mouse antral oocytes competent for development to blastocyst显示文摘 | ZUCCOTTI M PONCE R H BOIANI M | 2002 | Zygote2002，10，1： | 1 |
| 10 | Functional mapping of the promoter region of the GNB2LI human gene coding for RACK1 scaffold protein显示文摘 | Del Vecchio I Zuccotti A Pisano F | 2009 | Gene2009，430，： | 1 |
| 11 | Modulation of innate and adaptive immunity by lactoferrin in human immuno-defi-ciency virus(HIV)-infected,antiretroviral therapy nate children显示文摘 | ZUCCOTTI G V VIGANO A BORELLI M | 2007 | Int J Antimicrob Agents2007，29，3： | 1 |
| 12 | Full-term develop- ment of mice from enucleated oocytes injected with cumulus cell nuclei显示文摘 | Wakayama T Perry A C F Zuccotti M | 1998 | Nature1998，394，： | 1 |
| 13 | Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei 显示文摘 | Wakayama T Perry AC Zuccotti M | 1998 | Nature1998，394，6691： | 1 |
| 14 | Hepatitis B vaccination in infants of mothers infected with human immunodeficiency virus显示文摘 | Flumine P | 1994 | J Pediat1994，125，1： | 1 |
| 15 | Fullterm development of mice from nucleared oocyte injected with cumulus cell nuclei显示文摘 | WAKAYAMA T PERRY A C ZUCCOTTI M | 1998 | Nature1998，394，： | 1 |
| 16 | Probiotics inclinical practice An overview 显示文摘 | Zuccotti GV Meneghin F Raimondi C etal | 2008 | J Int Med Res2008，36，1： | 1 |
| 17 | Proposal of a step-wise follow-up for hepatitis C seropositive mothers and their infants显示文摘 | Cucchi C Torcoletti M | 2003 | Pediatr Med Chir2003，25，： | 1 |
| 18 | Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei 显示文摘 | Wakayama T Perry AC Zuccotti M | 1998 | Nature1998，394，6691： | 1 |
| 19 | Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei显示文摘 | Wakayama T Perry A C Zuccotti M | 1998 | Nature1998，394，： | 1 |
| 20 | Chromatin organization during mouse oocyte growth显示文摘 | Zuccotti M Piccinelli A Rossi P G | 1995 | Mol Re- prod Dev1995，41，4： | 1 |
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