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| 1 | Molecular basis for identification of species/isolates of gastrointestinal nematode parasites显示文摘Gastrointestinal(GI) parasitism is the most serious constraint throughout the world in small ruminants which causes significant production loss in animals.GI parasites are major contributor to reduce productivity in terms of meat,milk and wool in animals.Control of GI parasite is done primarily by anthelmintic treatment where choice and schedule of treatment is done after identification and quantitation of individual parasite.Identification of GI parasites is done through microscopic method by identifying specific morphological characteristics of egg and larva(L3).Since most of parasite eggs are having similar morphological characteristics, identification up to species level through microscopy is not possible in most of cases.To address this issue,molecular techniques are the viable alternative for identification of species as well as molecular level differences within a species(isolates) of parasites.Different DNA based molecular techniques viz.PCR,AFLP,RAPD,RFLP,PCR-SSCP,real time PCR,DNA microarray etc.have been used for identification and to assess the genetic diversity among parasite population.For identification of species,the characteristic sequence of genomic DNA of different species should differ to allow the delineation of species,but at the same time,no/minor variation within the species should exist.In contrast,for purpose of identifying population variants(strains/isolates), a considerable degree of variation in the sequence should exist within a species.Various target regions,including nuclear ribosomal DNA(rDNA),mitochondrial DNA(mtDNA) or repetitive DNA elements(microsatellite loci),which show considerable variation in the number of repeats within individuals have been employed to achieve the identification of parasites species or strain. | Ahmed M Singh MN Bera AK Bandyopadhyay S Bhattacharya D | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，8： | 6 |
| 2 | 中心和外周动脉脉搏波传导速度测量的重复性:社区动脉粥样硬化风险研究显示文摘通过脉搏波传导速度(pulsewavevelocity,PwV)检测动脉硬化程度是当前对高血压和心血管病风险评估和分层所日渐常用的方式。颈股动脉脉搏波传导速度(catroidfemoralarteryPWV,cfPWV)是一项公认的测定中心动脉硬化程度的方式。 | Meyer ML Tanaka H Palta P Patel MD Camplain R Couper D Cheng S Al Qunaibet A Poon AK Heiss G 陈云 叶鹏 | 2016 | 中华高血压杂志2016，24，5： | 6 |
| 3 | Biosynthesis of silver nanoparticles by using mangrove plant extract and their potential mosquito larvicidal property显示文摘Objective:To identify the larvicidal activities of silver nano particles synthesised with Rhizophora mucronata(R.mucronata) leaf extract against the larvae of Aedes aegypti(Ae.aegypti) and Culex quinquefasciatus(Cx.quinquefasciatus).Methods:In vitro larvicidal activities such as LC50 and LC90 were assessed for the Ae.aegypti and Cx.quinquefasciatus larval species.Further, characterisation such as UV,XRD,FTIR and AFM analysis were carried out for the synthesised silver nano particles.Results:The LC50 value of the synthesised silver nano particle was identified as 0.585 and 0.891 mgg/L for Ae.aegypti and Cx.quinquefasciatus larvae respectively. Further,the LG90 values are also identified as 2.615 and 6.291 mg/L for Ae.aegypti and Cx. quinquefasciatus species respectively.The synthesised silver nanoparticles have maximum absorption at 420 nm with the average size of 60-95 nm.The XRD data showed 20 intense values with various degrees such as 37.10°,47.66°,63.97°and 70.01°.The FTIR data showed prominent peaks in(3 426.89,2 925.49,2 869.56,2 346.95,1 631.49,1 031.73,669.18 and 455.12) different ranges.Conclusions:The biosynthesis of silver nanoparticles with leaf aqueous extract of R. mucronata provides potential source for the larvicidal activity against mosquito borne diseases. | M Gnanadesigan M Anand S Ravikumar M Maruthupandy V Vijayakumar S Selvam M Dhineshkumar AK Kumaraguru | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，10： | 4 |
| 4 | Healing property of the Piper betel phenol, allylpyrocatechol against indomethacin-induced stomach ulceration and mechanism of action显示文摘AIM: To evaluate the protective activity of allylpyrocatechol (APC), the major antioxidant constituent of Piper betel, against the indomethacin-induced stomach ulceration in the rat model and correlates with its antioxidative and mucin protecting properties. METHODS: Male Sprague-Dawley rats were divided into five groups. Normal control rats (group Ⅰ) were given the vehicle oral dose of gum acacia in distilled water (1 mL per rat); ulcerated control and treated rats (groups Ⅱ-Ⅴ) were given a single dose of indomethacin (30 mg/kg body wt.); group Ⅱ rats were sacrificed 4 h after indomethacin administration; groups Ⅲ-Ⅴ rats were given the vehicle (1 mL per rat) or APC (2 mg/kg body wt.) or misoprostol (1.43 μg/kg body wt.) once daily by oral intubation for 7 d starting from 4 h after the indomethacin administration. After 7 d, the stomach tissues were excised for histological examination and biochemical analysis. RESULTS: Treatment with APC (2 mg/kg body wt per day) and misoprostol (1.43 μg/kg body wt per day) for 7 d could effectively heal the stomach ulceration as revealed from the ulcer index and histopathological studies. Compared to the zero day ulcerated group, treatment with APC and misoprostol reduced the ulcer index by 93.4% and 85.4% respectively (P < 0.05). Both APC and misoprostol accelerated ulcer healing observed in natural recovery (P < 0.05), their respective healing capacities not being significantly different. The healing capacities of APC and misoprostol could be attributed to their antioxidant activity as well as the ability to enhancethe mucin content of the gastric tissues. Compared to the ulcerated untreated rats, those treated with APC and misoprostol showed near normal MDA levels, while the protein levels were 86% and 78% of the normal value respectively (P < 0.05). Likewise, both APC and misoprostol increased the SOD, catalase, and mucin levels significantly (P < 0.05), the effect of APC being better. CONCLUSION: APC can protect indomethacin-induced gastric ulceration due to its antioxidative and mucin protecting properties. | S Bhattacharya D Banerjee AK Bauri S Chattopadhyay SK Bandyopadhyay | 2007 | World Journal of Gastroenterology2007，13，27： | 4 |
| 5 | 妊娠并发症及妊娠特点与未来血压升高风险的关系显示文摘妊娠特点与心血管病风险相关,但其与高血压或血压水平的独立关联仍不明确。该研究将瑞典医学出生登记与Vsterbotten(瑞典北部)干预研究数据相联系。纳入妊娠前无高血压的40岁经产女性15 896人,用线性回归和Logistic回归分析以前妊娠因素与血压水平及高血压的关系。妊娠因素包括胎次、首次分娩年龄、子痫前期、妊娠期糖尿病、胎盘早剥、小于胎龄儿(出生体质量〈相同胎龄儿第3百分位)或死胎。 | Parikh NI Norberg M Ingelsson E Cnattingius S Vasan RS Domellf M Jansson JH Edstedt Bonamy AK 赵狄 练桂丽 | 2017 | 中华高血压杂志2017，25，2： | 3 |
| 6 | Anatomic restoration technique of continence mechanism and preservation of puboprostatic collar:a novel modification to achieve early urinary continence in men undergoing robotic prostatectomy显示文摘 | Tewari AK Bigelow K Rao S | 2007 | Urology2007，，04： | 2 |
| 7 | 高度近视伴色觉缺失的家系分析(英文)显示文摘目的:评估高度近视伴色觉缺失患者的遗传学特征和临床表现方法:就同一家族4代42个成员中有8位患者给予了详细的眼科检查,Ishihara盘和FM100H试验检测患者有无红绿色觉缺失,全视野视网膜电图评价其视网膜功能。结果:患者8位均因高度近视视力下降,其中6例有红绿色觉缺失,眼底检查显示以弥漫性视网膜脉络膜萎缩为特征的近视改变。2例患者ERG检查出现视杆细胞的暗适应异常和视锥细胞的反应消失,根据家系,红绿色觉缺失属X连锁的隐性遗传。结论:在这个家族成员中,同时发生的高度近视和色觉缺失可能有共同的遗传学基础。 | Nimet nay Gündogan Ay■e Gül Koak Altinta■ Nezih Durmazlar Koray Gümüs Zerrin Yilmaz Kemal Ksemehmetoglu | 2007 | 国际眼科杂志2007，7，3： | 2 |
| 8 | CpG motifs in bacterial DNA trigger direct B-cell activation 显示文摘 | Krieg AM Yi AK Matson S | 1995 | Nature1995，374，： | 2 |
| 9 | Outcome of retroperitoneal laparoscopic nephrectomy for benign nonfunctioning kidney:a single-center experience 显示文摘 | Gupta NP Hemal AK Mishra S | 2008 | J Endourol2008，22，4： | 1 |
| 10 | Transplanted human fetal neural stem cells survive,migrate,and differentiate in ischemic rat cerebral cortex显示文摘 | Kelly S Bliss TM Shah AK | 2004 | Proe Nail Aead Sei USA2004，101，11： | 1 |
| 11 | Ultrasonographic evaluation of gallbladder volume in diabetics显示文摘 | Agarwal AK Miglani S Singla S | 2004 | J Aseoc Physicians India2004，52，： | 1 |
| 12 | Squamous cell carcinoma of the thyroid 显示文摘 | Bal S Arunabb J | 1988 | J Surg Onco1988，39，1： | 1 |
| 13 | CpG motifs in bacteial DNA trigger direct B-cell activation显示文摘 | Yi AK Matson S | 1995 | Nature1995，374，： | 1 |
| 14 | Carotid intima media thickness:an independent marker for assessment of macrovascular risk in diabetic patients显示文摘 | Basu AK Pal SK Guha S | 2005 | Indian Med Assoc2005，103，4： | 1 |
| 15 | Anaphylactic reactions to proton-pump inhibitors 显示文摘 | Natsch S vinks MH Voogt AK | 2000 | Ann Pharmacother2000，34，4： | 1 |
| 16 | Neurotieism and stressful life events in patients with non - ulcer dyspepsia 显示文摘 | Jain AK Gupta JP Gupta S | 1995 | J Assoc Physicians India1995，43，： | 1 |
| 17 | Increased risk of acute myocardial infarction and elevated levels of C-reactive protein in carriers of t he Thr-87 variant of the ATP receptor P2Y11 显示文摘 | Amisten S Melander O Wihlborg AK | 2007 | Eur Heart J2007，28，1： | 1 |
| 18 | The relation between plasma endothelin-1 levels and metabolic control,risk factors,treatment modalities,and diabetic microangiopathy in patients with Type 2 diabetes mellitus显示文摘 | Ak G Buyukberber S Sevinc A | 2001 | Diabetes Complications2001，15，3： | 1 |
| 19 | High levels of interleukin 10 in serum are associated with fatality in meningococcal disease显示文摘 | Lehmann AK Halstensen A Sornes S | 1995 | Infect Immunol1995，63，6： | 1 |
| 20 | Studies on antidiarrhoeal activity granatum seed extract in rasts显示文摘 | Das AK Mandal SC Banenjee S K | 1999 | Ethnopharmacology1999，68，8： | 1 |
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