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| 1 | Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade显示文摘PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy.Delineating mechanisms of secondary resistance to this strategy is increasingly important.Here,we identified the deleterious role of signaling via the type I interferon(IFN)receptor in tumor and antigen presenting cells,that induced the expression of nitric oxide synthase 2(N0S2),associated with intratumor accumulation of regulatory T cells(Treg)and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody(mAb).Sustained IFNP transcription was observed in resistant tumors,in turn inducing PD-L1 and N0S2 expression in both tumor and dendritic cells(DC).Whereas PD-L1 was not involved in secondary resistance to anti-PD-1 mAb,pharmacological or genetic inhibition of N0S2 maintained long-term control of tumors by PD-1 blockade,through reduction of Treg and DC activation.Resistance to immunotherapies,including anti-PD-1 mAb in melanoma patients,was also correlated with the induction of a type I IFN signature.Hence,the role of type I IFN in response to PD-1 blockade should be revisited as sustained type I IFN signaling may contribute to resistance to therapy. | Nicolas Jacquelot Takahiro Yamazaki Maria PRoberti Connie PMDuong Miles CAndrews Loic Verlingue Gladys Ferrere Sonia Becharef Marie Vetizou Romain Daillere Meriem Messaoudene David PEnot Gautier Stoll Stefano Ugel Maria Marigo Shin Foong Ngiow Aurelien Marabelle Armelle Prevost-Blondel Pierre-Olivier Gaudreau Vancheswaran Gopalakrishnan Alexander MEggermont Paule Opolon Christophe Klein Gabriele Madonna Paolo AAscierto Antje Sucker Dirk Schadendorf Mark JSm yth Jean-Charles Soria Guido Kroemer Vincenzo Bronte Jennifer Wargo and Laurence Zitvogel | 2019 | Cell Research2019，29，10： | 6 |
| 2 | The Effects of Postoperative Pain Management on Immune Response to Surgery显示文摘 | Benzion Beilin Yehuda Shavit Evelyn Trabekin Boris Mordashev Eduard Mayburd Alexander Zeidel and Hanna Bessler | 2003 | Anesthesia & Analgesia2003，，3： | 2 |
| 3 | Is entrepreneurial success pre- dictable? An ex-ante analysis of the character-based approach 显示文摘 | Marco C and Alexander S K | 2008 | Kyklos2008，61，2： | 1 |
| 4 | Application to clinical and public health practice:a statement for health care professionals from the centers for disease control and prevention and American heart association显示文摘 | Person TA Mensah GA Alexander RW Markers of inflammation and cardiovascular disease | 2003 | Circulation2003，107，3： | 1 |
| 5 | Developing a Stress Testing Framework Based on Market Risk Models 显示文摘 | Alexander Carol and Elizabeth Sheedy | 2008 | Journal of Banking & Finance2008，，32： | 1 |
| 6 | Diffusion tensormagnetic resonance image regularization显示文摘 | Coulon O Alexander D C and Arridge S | 2004 | Medical ImageAnalysis2004，8，1： | 1 |
| 7 | Metal-based Inkjet Inks for Printed Electronics显示文摘 | Alexander Kamyshny Joachim Steinke and Shlomo Magdassi | 2011 | The Open Applied Physics Journal2011，4，： | 1 |
| 8 | Terahertz emission from localized modes in one-dimensional disordered systems [Invited]显示文摘We demonstrate terahertz(THz) frequency laser emission around 3.2 THz from localized modes in one-dimensional disordered grating systems. The disordered structures are patterned on top of the double-metal waveguide of a THz quantum cascade laser. Multiple emission peaks are observed within a frequency range corresponding to the bandgap of a periodic counterpart with no disorder, indicating the presence of mode localization aided by Bragg scattering. Simulations and experimental measurements provide strong evidence for the spatial localization of the THz laser modes. | YONGQUAN ZENG GUOZHEN LIANG Bo QIANG Bo MENG Hou KUN LIANG SHAMPY MANSHA JIANPING LI ZHAOHUI L LIANHE LI ALEXANDER GILES DAVIES EDMUND HAROLD LINFIELD YING ZHANG YIDONG CHONG AND Qi JIE WANG | 2018 | Photonics Research2018，6，2： | 1 |
| 9 | Area aggregation in map generalisation by mixed - integer pro- gramming显示文摘 | Haunert Jan- Henrik and Wolff Alexander(2010) | 2010 | International Journal of Geographical Infor- mation Science2010，，： | 1 |
| 10 | Value-at-risk-based risk man- agement:optimal policies and asset prices 显示文摘 | Basak Suleyman and Alexander Shapiro | 2001 | Review of Financial Studies2001，14，2： | 1 |
| 11 | Development of an Anomaly Detection Model for a Bank' s Transitory Account System显示文摘 | Yongbum Kim and Alexander Kogan | 2014 | Journal of Information Systems2014，，： | 1 |
| 12 | Differences in dental arch morphology among adult females with untreated Class Ⅰ and Class Ⅱ malocclusion 显示文摘 | Buschang PH J Stroud and RG Alexander | 1994 | Eur J Orthod1994，16，1： | 1 |
| 13 | Firm Value and Manage- rial Incentives: A Stochastic Frontier Approach 显示文摘 | Michal A Habib and Alexander Ljungqvist | 2005 | Journal of Bus- iness2005，6，78： | 1 |
| 14 | Value-at-Risk-Based risk management: Optimal policies and asset prices显示文摘 | Suleyman Basak and Alexander Shapiro | 2001 | Review of Financial Studies2001，14，2： | 1 |
| 15 | Organizational boundary spanning in institutionalized environment 显示文摘 | FennelM L and Alexander J A | 1987 | Academy of ManagementJournaU1987，30，3： | 1 |
| 16 | Private Benefits of Control: An International Comparison 显示文摘 | Dyck Alexander and Luigi Zingales | 2004 | The Journal of Finance2004，59，2： | 1 |
| 17 | Spatial compressive sensing for MIMO radar显示文摘 | MARCO ROSSI ALEXANDER M H and YONINA C E | 2014 | IEEE Transactions on Signal Processing2014，62，2： | 1 |
| 18 | A Predictive Ordered Logistic Regression Model as a Tool for Quality Review of Control Risk Assessments显示文摘 | Hussein Issa and Alexander Kogan | 2014 | Journal of Information Systems2014，，： | 1 |
| 19 | Is A Team Different From The Sum of Its Parts? Evidence from Mutual Fund Managers 显示文摘 | Bar Michaela Alexander Kempf and Stefan Ruenzi | 2011 | Review of Finance2011，，15： | 1 |
| 20 | Wave forces on vertical cylinders upon shoals显示文摘 | ALEXANDER K and ALF T | 1996 | Coastal Eng1996，27，： | 1 |
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