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| 1 | S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3显示文摘建筑群由 S100 钙绑定蛋白质家庭,的二个成员形成了 S100A8/A9,在不同起源的各种各样的房间施加导致 apoptosis 活动。这里,我们内在的分子的机制包含的现在的证据两个都规划了房间死亡我(PCD 我, apoptosis ) 并且象死亡一样的 PCD II (autophagy ) 。有 S100A8/A9 的房间的处理引起了 Beclin-1 表示以及 Atg12-Atg5 形成的增加。S100A8/A9-induced 房间死亡被特定的 PI3-kinase 班 III 禁止者部分禁止, 3-methyladenine (3 麻省) ,并且由液泡 H+-ATPase 禁止者, bafilomycin-A1 (Baf-A1 ) 。S100A8/A9 挑起了 BNIP3 的 translocation, BH3 仅仅 pro-apoptotic Bcl2 家庭成员,到线粒体。与这发现一致,螖 T M-BNIP3 overexpression 部分禁止了 S100A8/A9-induced 细胞死亡,减少的反应的氧种(ROS ) 产生,并且部分在 S100A8/A9-treated 细胞在 mitochondrial transmembrane 潜力免于减少。另外,任何一个螖 T M-BNIP3 overexpression 或 N-acetyl-L-cysteine 合作处理减少了在与 S100A8/A9 对待的房间的 lysosomal 激活。我们的数据显示 S100A8/A9-promoted 房间死亡通过线粒体的串音发生,经由 ROS 和这个过程的 lysosomes 包含 BNIP3。 | Saeid Ghavami Mehdi Eshragi Sudharsana R Ande Walter J Chazin Thomas Klonisch Andrew J Halayko Karol D Mcneill Mohammad Hashemi Claus Kerkhoff Marek Los | 2010 | Cell Research2010，20，3： | 13 |
| 2 | A framework infrageneric classification of Carex (Cyperaceae) and its organizing principles显示文摘Phylogenetic studies of Carex L.(Cyperaceae)have consistently demonstrated that most subgenera and sections are para-or polyphyletic.Yet,taxonomists continue to use subgenera and sections in Carex classification.Why?The Global Carex Group(GCG)here takes the position that the historical and continued use of subgenera and sections serves to(i)organize our understanding of lineages in Carex,(ii)create an identification mechanism to break the~2000 species of Carex into manageable groups and stimulate its study,and(iii)provide a framework to recognize morphologically diagnosable lineages within Carex.Unfortunately,the current understanding of phylogenetic relationships in Carex is not yet sufficient for a global reclassification of the genus within a Linnean infrageneric(sectional)framework.Rather than leaving Carex classification in its current state,which is misleading and confusing,we here take the intermediate steps of implementing the recently revised subgeneric classification and using a combination of informally named clades and formally named sections to reflect the current state of our knowledge.This hybrid classification framework is presented in an order corresponding to a linear arrangement of the clades on a ladderized phylogeny,largely based on the recent phylogenies published by the GCG.It organizes Carex into six subgenera,which are,in turn,subdivided into 62 formally named Linnean sections plus 49 informal groups.This framework will serve as a roadmap for research on Carex phylogeny,enabling further development of a complete reclassification by presenting relevant morphological and geographical information on clades where possible and standardizing the use of formal sectional names. | Eric H.Roalson Pedro Jiménez-Mejías Andrew L.Hipp Carmen Benítez-Benítez Leo P.Bruederle Kyong-Sook Chung Marcial Escudero Bruce A.Ford Kerry Ford Sebastian Gebauer Berit Gehrke Marlene Hahn Muhammad Qasim Hayat Mathias H.Hoffmann Xiao-Feng Jin Sangtae Kim Isabel Larridon Étienne Léveillé-Bourret Yi-Fei Lu Modesto Luceño Enrique Maguilla Jose IgnacioMárquez-Corro Santiago Martín-Bravo Tomomi Masaki Mónica Míguez Robert F.C.Naczi Anton A.Reznicek Daniel Spalink Julian R.Starr Uzma Tamara Villaverde Marcia J.Waterway Karen L.Wilson and Shu-Ren Zhang | 2021 | Journal of Systematics and Evolution2021，59，4： | 3 |
| 3 | Antisense Oligodeoxynucleotide Inhibits Expression of Re-com binantPorcine Follicle-Stim ulating Horm one Receptor显示文摘To assess the role of follicle stimulating hormone receptor(FSHR) gene expression in regulating expression of FSHR protein in the plasma membrane, the effects of a porcine FSHR cDNA antisense oligodeoxynucleotide (ODN) on FSHR mRNA levels and 125 I FSH binding were determined in Chinese hamster ovary cells expression recombinant porcine FSHR (pFSHR CHO cells). An 18 mer phosphorothioate endcapped antisense ODN that corresponded to the region surrounding the translation initiation codon of the porcine FSHR cDNA was synthesized. An 18 mer nonsense sequence of identical nucleotide composition, which had little homology to known DNA sequences, was synthesized for use as a control. pFSHR CHO cells were cultured in 24 well plates (10 5 cells/well) in the absence or presence of 1 20 μmol/L antisense or nonsense ODN for 24 h and then assayed for porcine FSHR mRNA, using quantitative reverse transcription and competitive polymerase chain reaction, and for 125 I FSH binding activity. Treatment with 10 μmol/L antisense ODN caused a paradoxical increase in porcine FSHR mRNA from 0.89±0.06 to 1.64±0.08 ng/mg total RNA ( P <0.05). Transfection with lipofectamine and 0.33 μmol/L antisense ODN caused an increase in porcine mRNA from 0.95±0.08 to 1.53±0.07 ng/mg total RAN. This was probably due to upregulation of mRNA synthesis resulting from inhibition of porcine FSHR protein translation. The nonsense ODN had no effect on porcine FSHR mRNA. Antisense, but not nonsense, ODN (10 μmol/L) inhibited membrane binding of 125 I FSH by 13.6± 0.8 % ( P <0.05) in 24 h. Treatment of cells with antisense ODN (10 μmol/L) for 48 h resulted in a 76±1.5 % ( P <0.05) inhibition of 125 I FSH binding. In contrast, transfection with lipofectamine and 0.33 μmol/L antisense ODN at 0 h caused a 76.1±1.3 % ( P <0.05) reduction in binding within 24 h. Binding had returned to 52.3±2.3 % ( P < 0.05) of normal by 48 h. These results indicate that an antisense ODN corresponding to the region of the translation start site of the porcine FSHR cDNA is an effective specific inhibitor of porcine FSHR synthesis and that inhibition of receptor synthesis causes a decrease in functional membrane bound FSHR. | ZHU Changhong 1, Mark D. Nixon 2, WANG Yifang 1, Andrew R. LaBarbera 3 1 Center of Reproductive Medicine, Tongji Hospital, Tongji Medical University, Wuhan 430030 2 Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0526 3 Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0526 | 1999 | Journal of Huazhong University of Science and Technology(Medical Sciences)1999，19，3： | 2 |
| 4 | LOV to BLUF: Flavoprotein Contributions to the Optogenetic Toolkit显示文摘Optogenetics 是联合光、基因的途径 non-invasively 与优美空间与时间的控制防碍细胞的事件的一块新兴的地。尽管它从神经科学原来产生了, optogenetics 对许多不同生物系统的学习广泛地适用,从这种技术产生的应用程序的范围继续增加。而且,使用设计新 optogenetic 工具的光敏感的蛋白质的全部剧目很快正在膨胀。察觉到的光,氧,或电压和 Blue-Light-Utilizing 黄素腺嘌 dinucleotide (一度时髦的风尚)(BLUF )(LOV ) 领域代表新贡献者到 optogenetic 工具箱。这些小(100140-amino 酸) 黄素蛋白模块从对 UV-A/blue 光作出回应的植物和细菌的光敏电阻器被导出。在最近的年里,可观的进步在揭开被成为了 LOV 和 BLUF 领域的 photoactivation 机制。这知识在合成 photoswitches 的设计被使用了并且荧光灯有在房间生物学和生物工学的应用的记者。在这评论,我们总结 LOV 和 BLUF photosensors 的光化学的性质并且加亮一些这些黄素蛋白怎么正在被采用人工地调整并且想象的最近的进展许多生物过程。 | John M. Christie Jayde Gawthorne Gillian Young Niall J. Fraser^c and Andrew J. Roe | 2012 | Molecular Plant2012，5，3： | 2 |
| 5 | Systems Integration:A Core Capability of the Modem Corporation显示文摘 | Hobday Michael Andrew Davies and Andrea Prencipe | 2005 | Industrial and Corporate Change2005，，14： | 1 |
| 6 | Harvey, Phase pupil functions for reduction of defocus and spherical aberrations显示文摘 | Samir Mezouari and Andrew R | 2003 | Optics Express2003，28，10： | 1 |
| 7 | 显示文摘 | Adrian Burton Andrew Treloar Deputy Directors Australian NationalData Service Designing for Discovery and Re-Use: the 4ANDS DataSharing Verbs’ Abroach to Service Deconqjosition | 2009 | The InternationalJournal of Digital2009，2009，3： | 1 |
| 8 | 'The Evolution of macro models at the Federal Reserve Board' 显示文摘 | Flint Levin Andrew Tryon Ralph and Williams John C | 1997 | Carnegie-Roehester Conference Series on Public Policy 471997，，47： | 1 |
| 9 | Index Option:The Early Evidence显示文摘 | Evnine Jeremy and Andrew Rudd | 1985 | Journal of Finance1985，，3： | 1 |
| 10 | Comparative Advantage and Heterogeneous Firms显示文摘 | Bernard Andrew Stephen Redding and Peter Schott | 2007 | Review of Economic Studies2007，73，1： | 1 |
| 11 | Prepayment Risk and Option-Adjusted Valution of MBS显示文摘 | AlexanderLevin and Andrew Davidson | 2005 | Jottmal of Portfolio Management2005，，3： | 1 |
| 12 | Quantitative Eas- ing And Unconventionalmonetary Policy - An Introduction显示文摘 | Michael Joyce David Miles Andrew Scott and Dimitri Vayanos | 2012 | The Economic Journal2012，，122： | 1 |
| 13 | What Is the DemographicDividend显示文摘 | Lee Ronald and Andrew Mason | 2006 | Finance and Development2006，，3： | 1 |
| 14 | The future of distributed models:model calibration and uncertainty predication显示文摘 | | 1992 | Hydrological Process1992，，6： | 1 |
| 15 | Treatment and control of an outbreak of fat cow dairy herd 显示文摘 | Andrews A H R Laven and I Maisey | 1991 | Vet Rec1991，129，： | 1 |
| 16 | Crying Wolf: An Examination and Reconsideration of the Perception of Crisis in LIS Education 显示文摘 | Dillon Andrew and Norris April | 2005 | Journal of Education for Library and Information Science2005，46，4： | 1 |
| 17 | The ATHEROMA (Atorvastatin Therapy: Effects on Reduction of Macrophage Activity) Study显示文摘 | Tjun Y. Tang Simon P.S. Howarth Sam R. Miller Martin J. Graves Andrew J. Patterson Jean-Marie U-King-Im Zhi Y. Li Stewart R. Walsh Andrew P. Brown Peter J. Kirkpatrick Elizabeth A. Warburton Paul D. Hayes Kevin Varty Jonathan R. Boyle Michael E. Gaunt And | 2009 | Journal of the American College of Cardiology2009，，22： | 1 |
| 18 | Physical layer security in downlink multi-antenna cellular networks显示文摘 | Geraci G Dhillon H and Andrews J | 2014 | IEEE Transactions on Communications2014，62，6： | 1 |
| 19 | Soil respiration and the global carbon cycle 显示文摘 | Schlesinger W H and Andrews J A | 2000 | Biogeochemistry2000，48，： | 1 |
| 20 | The Effect of Gelatin on the Preparation of Silica Coated Iron Particles显示文摘 | WANG Gui hua 1,* and Andrew Harrison 2 (1. Department of Chemistry, Shanghai Normal University, Shanghai 200234, P. R. China 2. Department of Chemistry, The University of Edinburgh, Edinburgh, EH9 3JJ, UK) | 2000 | Chemical Research in Chinese Universities2000，16，3： | 1 |
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