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| 1 | Ghrelin and gastrin in advanced gastric cancer before and after gastrectomy显示文摘AIM: To investigate plasma ghrelin, gastrin and growth hormone secretagogue receptor (GHS-R) expression in advanced gastric cancer (GC) before and after resection. METHODS: Seventy subjects in whom endoscopy of the upper gastrointestinal tract was performed in the Department of General Surgery at Cracow University during the past decade: (1) 25 patients with GC associated with Helicobacter pylori (H. pylori) infection; (2) 10 patients with GC 4-5 years after (total or subtotal) gastrectomy; (3) 25 healthy H. pylori-negative controls, matched by age and BMI to the above two groups; and (4) 10 GC patients 4-5 years after total gastrectomy. Ghrelin and gastrin plasma concentrations were measured by specific radioimmunoassay under fasting conditions and postprandially at 60 and 90 min after ingestion of a mixed meal. GHS-R expression was examined in biopsy samples from intact healthy mucosa and GC tissue using semi-quantitative reverse transcription-polymerase chain reaction. RESULTS: In healthy controls, fasting plasma ghrelin levels were significantly elevated and declined markedly at 60 and 90 min after a mixed meal. The concomitant enhanced ghrelin, GHS-R and gastrin expression in GC tissue over that recorded in intact mucosa, and the marked rise in plasma gastrin in these subjects under fasting conditions indicate the role of these hormonal factors in GC formation. Fasting plasma levels and postprandial response of ghrelin and gastrin appear to be inversely correlated in healthy subjects. Feeding in the controls resulted in a significant fall in plasma ghrelin with a subsequent rise in plasma gastrin, but in H. pylori-positive GC patients submitted to total or distal gastrectomy, feeding failed to affect significantly the fall in plasma ghrelin that was recorded in these patients before surgery. Fasting ghrelin concentrations were significantly lower in patients 4-5 years after total gastrectomy compared to those in healthy controls and to these in GC patients before surgery. CONCLUSION: Elevated plasma gastrin and suppression of fasting ghrelin in patients with GC suggest the existence of a close relationship between these two hormones in gastric carcinogenesis. | Anna Zub-Pokrowiecka Kazimierz Rembiasz Peter C Konturek Andrzej Budzyński Stanisaw J Konturek Marek Winiarski Wadysaw Bielański | 2011 | World Journal of Gastroenterology2011，17，4： | 7 |
| 2 | 脊髓损伤后残存自主神经功能载录国际标准显示文摘近年来,脊髓损伤神经学分类园际标准(International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI)被用来记载脊髓损伤后运动和感觉功能的损害,目前该标准已是第六版。1992年第一份国际认可的标准出版时,曾进行了较大的修订,修订内容包括完全性损伤与不完全性损伤的定义, | MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望 刘楠 S Charlifue | 2010 | 中华物理医学与康复杂志2010，32，4： | 2 |
| 3 | Phase Ⅰ study of twice-weekly gemcitabine and concurrent thoracic radiation for patients with locally advanced non-small-cell lung cancer显示文摘 | Blackstock AW Lesser GJ Fletcher-Steede J | 2001 | Int J Rad Ocol Biol Phys2001，51，5： | 1 |
| 4 | Quality of life with a temporary stoma: ileostomy vs colost0my 显示文摘 | Gooszen AW Geelkerken RH Hermans J | 2000 | Dis Colon Rectum2000，43，5： | 1 |
| 5 | Iatrogenic nerve injury with the Russell-Taylor humeral nail显示文摘 | Blyth M J Macleod CM Asante DK Kinninmonth AW | 2003 | Injury2003，34，： | 1 |
| 6 | Pessible formation of ethanol in postmortem blood specimens after antemortem treatment with mannitol显示文摘 | Jones AW Andersson R Sakshang J | 1991 | J Anal Toxicol1991，15，3： | 1 |
| 7 | Intra-abdominal hypertension and abdominal compartment syndrome 显示文摘 | De Waele J J De Laet 1 Kirkpatrick AW | 2011 | Am J Kidney Dis2011，57，1： | 1 |
| 8 | Age-dependent changes in heparan sulfate in human Bruch' s membrane: implications for age- related macular degeneration 显示文摘 | KEENAN TD PICKFORD CE HOLLEY R J CLARK S J LIN W DOWSEY AW | 2014 | Invest Ophthalmol Vis Sci2014，55，8： | 1 |
| 9 | Anesthetic concentrations of propofol protect against oxidative stress in primary astrocyte cultures: comparison with hypothermia 显示文摘 | PETERS CE KORCOK J GELB AW | 2001 | Anesthesiology2001，94，2： | 1 |
| 10 | Second prevention of coronary heart disease : patients beliefs and health-related behaviour显示文摘 | Byrne M Walsh J Murphy AW | 2005 | J Psychosom Res2005，58，5： | 1 |
| 11 | Glucocorticosteroid in- duced spinal osteoporosis: scientific update on pathophysiology and treatment显示文摘 | Popp AW Lsenegger J Buergi EM | 2006 | Eur Soine J2006，15，： | 1 |
| 12 | Identification of the hu- man liver cytochrome P - 450 responsible for coumarin 7 - Hydroxy- lase activity显示文摘 | Miles J Mclaren AW Forrester LM | 1990 | Biochem J1990，267，： | 1 |
| 13 | Use of prostate-specific antigen (PSA) isoforms for the detection of prostate cancer in men with a PSA Level of 2-10 ng/ml: systematic review and meta-analysis显示文摘 | Roddam AW Duffy M J Hamdy FC | 2005 | Eur Urol2005，48，6： | 1 |
| 14 | Appreciable blcod-ethanal concentration after washing abraised and lacerated skin with surgical spirit 显示文摘 | Jones AW Rajs J | 1997 | J Anal Toxicol1997，21，7： | 1 |
| 15 | Ultrasound-guided fine-needle aspiration biopsy of thyroid nodules smaller than 5 mm in the maximum diameter: assessment of efficacy and pathological findings 显示文摘 | Kim DW Park AW Lee E J | 2009 | Korean J Radiol2009，10，5： | 1 |
| 16 | Mast cells as rapid innate sensors of cytomegalovirus by TLR3/TRIF signaling-dependent and -independent mechanisms显示文摘简明比喻, ‘免疫系统装载了 gun' ,被用来在能在需求上几乎立即被释放与侵略者作斗争的能分泌的小粒由于他们大量有势力支持 inflammatory 和抗菌剂调停人的存储描述桅杆房间(MC ) 的角色。在主人环境定位了边界并且与模式识别受体的一个军火库装备了, MC 被注定是渗透 endothelial 和上皮的表面的病原体的快速的天生的传感器。尽管在抗菌剂和 antiparasitic 防卫的 MC 的重要性长被欣赏了,他们在对病毒的感染发出报警的角色仅仅最近被注意了。 cytomegalovirus ( CMV )上的工作在鼠科的模型的感染在在 CMV 的天生、适应的有免疫力的监视之间的新奇串音轴作为播放器揭示了 MC 在 MC ,它与 MC degranulation 和 chemokine CCL5 的版本被联系的那感染,提高保护的 CD8 T 房间的招募到病毒复制的血管外的地点,明确地到肺 interstitium 和牙槽的上皮。这里,我们由响应主人感染为 MC 激活和作为结果的 degranulation 调查条件阐述了这些研究。令人惊讶地,数据揭示了 MC 激活的二个时间地并且机械学地不同的波浪:取决于 TLR3/TRIF 发信号并且由没包含 TLR3/TRIF 发信号的 MC 的直接感染推迟了激活的几乎立刻的间接激活。产出有选择地从 MC 发源的表示 eGFP 记者病毒的房间类型特定的 Cre 再结合识别了是的 MC 一在 vivo 新,生产鼠科的 CMV 感染的第一点击的目标房间。 | Marc Becker Niels AW Lemmermann Stefan Ebert Pamela Baars Angelique Renzaho Jurgen Podlech Michael Stassen Matthias J Reddehase | 2015 | Cellular & Molecular Immunology2015，12，2： | 1 |
| 17 | Proteomic screening of a cell line model of esophageal carcinogenesis identifies cathepsin D and aldo-keto reductase 1C2 and 1B10 dysregulation in Barrett's esophagus and esophageal adenocarcinoma显示文摘 | Breton J Gage MC Hay AW | 2008 | J Proteome Res2008，7，5： | 1 |
| 18 | Spatial and temporal distribution of nerves, ganglia, and smooth muscle during the early pseudoglandular stage of fetal mouse lung development 显示文摘 | Tollet J Everett AW Sparrow MP | 2001 | Dev Dyn2001，221，1： | 1 |
| 19 | Genera- tion of isogenic pluripotent stem cells differing exclu- sively at two early onset Parkinson point mutations显示文摘 | Soldner F Laganiere J Cheng AW | 2011 | Cell2011，146，： | 1 |
| 20 | Hearts and bones: Shared regulatory mechanisms in heart valve, cartilage, tendon, and bone development显示文摘 | Lincoln J Lange AW Yutzey KE | 2006 | Developmental Biology2006，294，2： | 1 |
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