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| 1 | Histopathology of nonalcoholic fatty liver disease显示文摘Histological analysis of liver biopsies remains a standard against which other methods of assessment for the presence and amount of hepatic injury due to nonalcoholic fatty liver disease(NAFLD) are measured.Histological evaluation remains the sole method of distinguishing steatosis from advanced forms of NAFLD,i.e.nonalcoholic steatohepatitis(NASH) and fibrosis.Included in the lesions of NAFLD are steatosis,lobular and portal inflammation,hepatocyte injury in the forms of ballooning and apoptosis,and fibrosis.However,patterns of these lesions are as distinguishing as the lesions themselves.Liver injury in adults and children due to NAFLD may have different histological patterns.In this review,the rationale for liver biopsy,as well as the histopathological lesions,the microscopically observable patterns of injury,and the differential diagnoses of NAFLD and NASH are discussed. | Elizabeth M Brunt Dina G Tiniakos | 2010 | World Journal of Gastroenterology2010，16，42： | 16 |
| 2 | Role of liver biopsy in nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD), defined as abnormal accumulation(> 5%) of hepatic triglyceride without excess alcohol intake, is the most common form of chronic liver disease in adults and children in the United States. NAFLD encompasses a spectrum of histologic findings including uncomplicated steatosis, steatosis with inflammation and steatohepatitis [nonalcoholic steatohepatitis(NASH)]; the latter can advance to cirrhosis and hepatocellular carcinoma. NASH is currently accepted as the hepatic manifestation of the set of cardiovascular risk factors collectively known as metabolic syndrome. In 1999 a system for histologic grading and staging for NASH was proposed; this was revised by the NASH Clinical Research Network in 2005 for the entire spectrum of lesions in NAFLD, including the lesions and patterns of pediatric NAFLD, and for application in clinical research trials. Diagnosis remains distinct from grade and stage. A recent European proposal separates steatosis from activity to derive a numeric diagnosis of NASH. Even though there have been promising advancements in non-invasive testing, these tests are not yet detailed enough to replace the full range of findings provided by liver biopsy evaluation. Limitations of biopsy are acknowledged, but liver biopsy remains the 'gold standard' for diagnosis and determination of amounts of necroinflammatory activity, and location of fibrosis, as well as remodeling of the parenchyma in NASH. This review focuses on the specific histologic lesions of NAFLD and NASH, grading and staging, differential diagnoses to be considered, and the continuing role of the liver biopsy in this important liver disease. | ILKe Nalbantoglu Elizabeth M Brunt | 2014 | World Journal of Gastroenterology2014，20，27： | 16 |
| 3 | Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions显示文摘 | Elizabeth M Brunt Christine G Janney Adrian M Di Bisceglie Brent A Neuschwander-Tetri Bruce R Bacon | 1999 | The American Journal of Gastroenterology1999，，9： | 3 |
| 4 | Positron emission tomography scanning in the evaluation of hepatocellular carcinoma显示文摘 | M.Akram Khan Connie S Combs Elizabeth M Brunt Val J Lowe Michael K Wolverson Harvey Solomon Brian T Collins Adrian M.Di Bisceglie | 2000 | Journal of Hepatology2000，，5： | 2 |
| 5 | Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions显示文摘 | Elizabeth M Brunt Christine G Janney Adrian M Di Bisceglie Brent A Neuschwander-Tetri Bruce R Bacon | 1999 | The American Journal of Gastroenterology1999，，9： | 2 |
| 6 | Does Nonalcoholic Fatty Liver Disease Predispose Patients to Hepatocellular Carcinoma in the Absence of Cirrhosis?显示文摘 | Guzman Grace Brunt Elizabeth M Petrovic Lydia M Chejfec Gregorio Layden Thomas J Cotler Scott J | 2008 | Archives of Pathology & Laboratory Medicine2008，，11： | 2 |
| 7 | Identification ofCorona Discharge-induced SF6 Qxidation Mechanisms UsingSF6/18 O2/H126O and SF6/16 O2/H128O Gas Mixtures显示文摘 | BRUNT V R J SIDDAGANGAPPA M | 1988 | Plas-ma Chemistry and Plasma Processing1988，8，2： | 1 |
| 8 | Surgery for benign insulinoma:an intetnational review显示文摘 | Rothmund M Aneglini L Brunt LM | 1990 | Would J Surg1990，14，3： | 1 |
| 9 | Nonalcoholic fatty liver disease显示文摘 | Law K Brunt E M | | 0，，04： | 1 |
| 10 | Athletic footwear,leg stiffness,and running kinematics显示文摘 | Bishop M Fiolkowski P Conrad B Brunt D Horodyski M | | 0，，： | 1 |
| 11 | Perioperative outcomes and complications of open vs lapamscopic extraperitoneal inguinal hernia repair in a mature surgical practice 显示文摘 | Winslow E R Quasebarth M Brunt L M | 2004 | Surg Endosc2004，18，2： | 1 |
| 12 | Nonalcoholic steatohepatitis 显示文摘 | Brunt E M | 2004 | Semin Liver Dis2004，24，1： | 1 |
| 13 | Design and validationof a histological scoring system for nonalcoholic fatty liver disease显示文摘 | Kleiner DE Brunt EM Van Natta M | 2005 | Hepatology2005，41，6： | 1 |
| 14 | Grading and staging the histopathological lesions of chronic hepatitis: The Knodell histology activity index and beyond显示文摘 | Brunt E M | 2000 | Hepatology2000，31，1： | 1 |
| 15 | The quantification of thiosulfate and polythionates in gold leach solutions and anion exchange resins 显示文摘 | JEFFREY M I BRUNT S D | 2007 | Hydrometallurgy2007，5，15： | 1 |
| 16 | Design and validation of a histological scoring system for nonalcoholic fatty liver disease 显示文摘 | Kleiner DE Brunt EM Van Natta M | 2005 | Hepatology2005，41，6： | 1 |
| 17 | Portal vein thrombosis after splenectomy显示文摘 | Winslow E R Brunt L M Drebin J A | 2002 | The American Journal of Surgery2002，184，6： | 1 |
| 18 | Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace显示文摘 | BAFFY G BRUNT E M CALDWELL SH | 2012 | J Hepatol2012，56，6： | 1 |
| 19 | Design and validation of a histological scoring system for nonalcoholic fatty liver disease 显示文摘 | Kleiner DE Brunt EM Van Natta M | 2005 | Hepatology2005，41，6： | 1 |
| 20 | Surgery for benign insu- liboma : an international review显示文摘 | Rothmund M Angelini L Brunt LM | 1990 | World J Surg1990，14，3： | 1 |
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