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| 1 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 2 | New therapeutic opportunities for Hepatitis C based on small RNA显示文摘Hepatitis C virus (HCV) infection is one of the major causes of chronic liver disease, including cirrhosis and liver cancer and is therefore, the most common indication for liver transplantation. Conventional antiviral drugs such as pegylated interferon-alpha, taken in combination with ribavirin, represent a milestone in the therapy of this disease. However, due to different viral and host factors, clinical success can be achieved only in approximately half of patients, making urgent the requirement of exploiting alternative approaches for HCV therapy. Fortunately, recent advances in the understanding of HCV viral replication and host cell interactions have opened new possibilities for therapeutic intervention. The most recent technologies, such as small interference RNA mediated gene-silencing, anti-sense oligonucleotides (ASO), or viral vector based gene delivery systems, have paved the way to develop novel therapeutic modalities for HCV. In this review, we outline the application of these technologies in the context of HCV therapy. In particular, we will focus on the newly defined role of cellular microRNA (miR-122) in viral replication and discuss its potential for HCV molecular therapy. | Qiu-wei Pan Scot D Henry Bob J Scholte Hugo W Tilanus Harry LA Janssen Luc JW van der Laan | 2007 | World Journal of Gastroenterology2007，13，33： | 4 |
| 3 | Nitric oxide modulation of TNF- alpha- induced cardiac contractile dysfunction is concentration dependent显示文摘 | Horton JW Maass D White J | 2000 | Am J Physiol2000，278，6： | 2 |
| 4 | Dendritic cells 显示文摘 | Bell D Young JW Banchereau J | 1999 | Adv Immunol1999，72，： | 1 |
| 5 | Review article:the management of acute variceal bleeding 显示文摘 | Ferguson JW Tripathi D Hayes PC | 2003 | Aliment Pharmacol Ther2003，18，1112： | 1 |
| 6 | Phytic Acid Determination in Soybeans显示文摘 | | 1982 | J Food Sci1982，47，2： | 1 |
| 7 | The dependence of ultrasonic attenuation and backscatter on collagen content in dog and rabbit hearts显示文摘 | Mimbs JW O'Donnell M Bauwens D | 1980 | Cite Res1980，47，： | 1 |
| 8 | Ultrasound guided tfhrombin injection for the treatment of postcatheterixation pseudoaneurysms显示文摘 | Perna LL Olin JW Goines D | 2000 | Circulation2000，102，： | 1 |
| 9 | Increased uncouplingprotein-2 levels inβ-cells are associated with impaired glucose-stimulated insulin secretion:mechanism of action显示文摘 | Chan CB De Leo D Joseph JW | 2001 | Diabetes2001，50，： | 1 |
| 10 | Alternative slicing for theα1 subunit of soluble guanylate cyclase 显示文摘 | Ritter D Taylor JF Hoffmmm JW | 2000 | Biochem J2000，348，： | 1 |
| 11 | Early cleft palate repair and speech outcome显示文摘 | Dorf D Curtin JW | 1982 | Plast Reconstr Surg1982，70，1： | 1 |
| 12 | Time course of appearance and disappearance of human mast cell tryptase in the circulation after anaphylaxis显示文摘 | Schwartz LB Yunginger JW Miller J Bokhari R Dull D | 1989 | J Clin Invest1989，83，5： | 1 |
| 13 | The Haemophilus infiuenzae Hia adhesin is an autotransporter protein that remains uncleaved at the C terminus and fully cell associated显示文摘 | St Geme JW Ⅲ Cutter D | 2000 | J Bacteriol2000，182，： | 1 |
| 14 | Safety of total thyroidectomy显示文摘 | Serpell JW Phan D | 2007 | ANZ J Surg2007，77，12： | 1 |
| 15 | The long-term effects ofspinal fusion on the sacroiliac joints and ilium 显示文摘 | Fryraoyer JW Howe J Kuhlmann D | 1978 | Clin OrthopHelat Res1978，，134： | 1 |
| 16 | Safety of total thyroidectomy显示文摘 | Serpell JW Phan D | 2007 | ANZ J Surg2007，77，12： | 1 |
| 17 | Differential expression of progre- ssion-related genes in the evolution of superficial to invasive transitional cell carcinoma of the bladder显示文摘 | Izawa JI Slaton JW Kedar D | 2001 | Oncol Rep2001，8，1： | 1 |
| 18 | Sertraline effects ondyspnea in patients with obstructive airways disease显示文摘 | Smoler JW Pollack MH Systrom D | 1998 | Psychosomatics1998，39，： | 1 |
| 19 | Evaluation of dental ceramics in the twenties century显示文摘 | Mclean JW Odont D | 2001 | J Prothet Dent2001，88，1： | 1 |
| 20 | Four-marker serum screening for Down' s syndrome显示文摘 | Wald N J Densem JW Smith D | 1994 | Prenat Diagn1994，14，： | 1 |
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