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| 1 | Characterization of goat whey proteins and their bioactivity and toxicity assay显示文摘Goat whey is an industry-discarded dairy by-product that has interesting nutritional value and a nutrient composition with important functional potential,where proteins have a high biological value and play an important role in the organism’s physiology.Therefore,the aim of this study was to identify,quantify,concentrate and investigate the capacity of goat whey proteins to perform different biological activities and to evaluate their acute toxicity.Concentrated proteins were quantified and identified by Bradford,Kjehdal and SDS-PAGE methods.Antibacterial activity was performed against Listeria monocytogenes,Salmonella spp.,Staphylococcus aureus,Pseudomonas aeruginosa and Escherichia coli microorganisms and showed MIC ranging from 15 to 120μg mL-1,with the highest inhibition for L.monocytogenes growth.Antiproliferative activity was performed against human malignant melanoma cells and their proliferation inhibition was up to 66.8%within 72 h of exposure.The highest antioxidant capacity was obtained at concentration 2 mg that showed 29.69%of inhibition of DPPH radical oxidation.The acute toxicity test was performed using Artemia franciscana larvae in which whey proteins were able to preserve larval survival throughout exposure.Thus,we can conclude that goat’s whey has proteins that can play a positive effect on health,with antimicrobial activity and without toxicity.The present study highlights the great potential of goat’s whey to be developed as a safe biopreservative or as a functional ingredient in the food industry. | Maria Isabel Ferreira Campos Paula Perazzo de Souza Barbosa Laura Junqueira Camargo Luciano Da Silva Pinto Bianca Mataribu Catarina Serr˜ao Luis Fernando Marques-Santos Jos´e Hon´orio Lopes Julia Mariano Caju de Oliveira Carlos Alberto de Almeida Gadelha Tatiane Santi-Gadelha | 2022 | Food Bioscience2022，46，2： | 2 |
| 2 | Importance of viral and bacterial infections in chronic obstructive disease eacerbations显示文摘 | De Serres G Lampron N La Forge J | 2009 | Clin Virol2009，46，2： | 1 |
| 3 | Evaluation of C4d deposition and circulating antibody in small bowel transplantation显示文摘 | de Serre N P Canioni D Lacaille F | 2008 | Am J Transplant2008，8，6： | 1 |
| 4 | Vagal afferent ne- urons in high fat diet-induced obesity;intestinal microflora,gut inflammation and cholecystokinin 显示文摘 | de Lartigue G de La Serre CB Raybould HE | 2011 | Physiol Behav2011，105，1： | 1 |
| 5 | Human metapneumovirus infections in hospitalized children 显示文摘 | Boivin G De Serres G Cote S | 2003 | Emerg Infect Dis2003，9，： | 1 |
| 6 | Long-term follow-up of 61 celiac patients diagnosed in childhood: evolution toward latency is possible on a normal diet 显示文摘 | Matysiak-Butnik T Malamut G Patey-Mariaud de Serre N | 2007 | Gut2007，56，10： | 1 |
| 7 | Have developed countries escaped the curse of distance显示文摘 | Herve' Boulhol Alain de Serres | 2010 | Journal of Economic Geography2010，，10： | 1 |
| 8 | Comparison of the spectra of genetic damage in formaldehyde-induced sol-3 mutations between DNA repair-proficient and-deficient heterokaryons of Neurospora crassa显示文摘 | De Serres FJ Brockman HE | 1999 | Mutat-Res1999，437，： | 1 |
| 9 | Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer 2009: four observational studies from Canada显示文摘 | Skowronski DM De Serres G Crowcroft NS | 2010 | PLoS Med2010，7，10： | 1 |
| 10 | Contagious piriod for pandemic (H1N1)2009显示文摘 | de Serres G Rouleau I Hamelin ME | 2010 | Emerg Infect Dis2010，16，5： | 1 |
| 11 | Propensity to high-fat diet-induced obesity in rats is associated with changes in the gutmicrobiota and gut inflammation显示文摘 | de la SERRE C B ELLIS C L LEE J | 2010 | Am J Physiol Gastrointest LiverPhysiol2010，299，2： | 1 |
| 12 | Importance of viral and bacterial infections in chronic obstructive pulmonary disease exacerbations显示文摘 | De Serres G Lampron N La Forge J | 2009 | J cu? Viral2009，46，2： | 1 |
| 13 | Propensity to high-fat diet-induced obesity in rats is associated with changes in the gutmicrobiota and gut inflammation 显示文摘 | de la SERRE C B ELLIS C L LEE J | 2010 | American Journal of Physiology-Gastrointestinal and Liver Physiology2010，299，2： | 1 |
| 14 | Measuring quality of life in children with obstructive sleep disorders显示文摘 | De Serres L M Derkay C Astley S | 2000 | Arch Otolaryngol Head Neck Surg2000，126，12： | 1 |
| 15 | The effect of changing from whole p-cell to acellular pertussis vaccine on the epidemiology of hospital-ised children with pertussis in Canada显示文摘 | Bettinger J Halperin S De Serres G | 2007 | Pediatr Infect Dis2007，26，1： | 1 |
| 16 | Pertussis resurgence in Canada largely caused by a cohort effect显示文摘 | Ntezayabo B De Serres G Duval B | 2003 | Pediatr Infect Dis J2003，22，1： | 1 |
| 17 | ICAM-3 and E-selectin endothelial cell expression differentiate two phases of angiogenesis in infantile hemangiomas显示文摘 | Verkarre V Patey-Mariaud de Serre N Vazeux R | 1999 | J Cutan Pathol1999，26，1： | 1 |
| 18 | Worldwide Racial and Ethnic Distribution of α 1 -Antitrypsin Deficiency显示文摘 | Frederick J. de Serres | 2002 | Chest2002，，5： | 1 |
| 19 | Importance of viral and bacterial infections in chronic obstructive pulmonary disease exacerbations显示文摘 | De Serres G Lampron N La Forge J | 2009 | J Clin Virol2009，46，2： | 1 |
| 20 | Measuring quality of life in children with obstructive sleep disorders显示文摘 | De Serres LM Derkay C Astley S | 2000 | Arch Otolaryngol Head Neck Surg2000，126，： | 1 |
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