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| 1 | 代谢型谷氨酸受体可作为一种新型恶性胶质瘤治疗靶点(英文)显示文摘Objective Metabotropic glutamate receptors(mG luR)are predominantly involved in maintenance of cellular homeostasis of central nervous system.However,evidences have suggested other roles of mG luR in human tumors.Aberrant mG luR signaling has been shown to participate in transformation and maintenance of various cancer types,including malignant brain tumors.This review intends to summarize recent findings regarding the involvement of mG luR-mediated intracellular signaling pathways in progression,aggressiveness,and recurrence of malignant gliomas,mainly glioblastomas(GBM),highlighting the potential therapeutic applications of mG luR ligands.In addition to the growing number of studies reporting mG luR gene or protein expression in glioma samples(resections,lineages,and primary cultures),pharmacological blockade in vitro of mG luR1 and mG luR3 by selective ligands has been shown to be anti-proliferative and anti-migratory,decreasing activation of MAPK and PI3K pathways.In addition,mG luR3 antagonists promoted astroglial differentiation of GBM cells and also enabled cytotoxic action of temozolomide(TMZ).mG luR3-dependent TMZ toxicity was supported by increasing levels of MGMT transcripts through an intracellular signaling pathway that sequentially involves PI3K and NF-κB.Further,continuous pharmacological blockade of mG luR1 and mG luR3 have been shown to reduced growth of GBM tumor in two independent in vivo xenograft models.In parallel,low levels of mG luR3 mRNA in GBM resections may be a predictor for long survival rate of patients.Since several Phase I,II and III clinical trials are being performed using group I and II mG luR modulators,there is a strong scientifically-based rationale for testing mG luR antagonists as an adjuvant therapy for malignant brain tumors. | Pereira MS Klamt F Thomé CC Worm PV de Oliveira DL | 2017 | 中华神经外科疾病研究杂志2017，16，1： | 3 |
| 2 | Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone显示文摘 | Hauschka PV Lian JB Cole DE | 1989 | Physiol Rev1989，69，3： | 1 |
| 3 | Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone显示文摘 | Hanschka PV Lian JB Code DE | 1989 | Physiol Rev1989，69，3： | 1 |
| 4 | Osteoealcin and matrix Gla pro- tein: Vitamin K- dependent proteins in bone显示文摘 | Hauschka PV Lian JB Cole DE | 1989 | Physiol Rev1989，69，3： | 1 |
| 5 | Comparative osteogenic transcription profiling of various fetal and adult mesenchymal stem cell sources 显示文摘 | Guillot PV De Bari C Dell'Aecio F | 2008 | Differentiation2008，76，9： | 1 |
| 6 | Detennining hypertensive end-organ damage in trials: a review of current methodologies and techniques显示文摘 | Birkenhager WH de Leeuw PV/ | 1992 | J Cardiovasc Phatmacol1992，19，5： | 1 |
| 7 | Osteocalcin and matrix protein:vitamin K-dependent proteins in bone显示文摘 | Hauschka PV Lian JB Cole DE | 1989 | Physiol Rev1989，69，3： | 1 |
| 8 | Orthodontic movement in bone defects filled with xenogenic graft:an experimental study in minipigs显示文摘 | Oltramari PV de Lima Navarro R Henriques JF | 2007 | Am J Orthod Dentofacial Orthop2007，131，3： | 1 |
| 9 | The first report of orthotopic liver transplantation in the Western world显示文摘 | Busuttil RW De Carlis LG Mihaylov PV | 2012 | Am J Transplant2012，12，6： | 1 |
| 10 | Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone显示文摘 | Hauschka PV Lian JB Cole DE et aT | 1989 | Physiol Rev1989，69，： | 1 |
| 11 | Predictive power of T-wave ahernans and of ventricular gradient hysteresis for the occurrence of ventricular arrhythmias in primary pre- vention eardioverter-defibrillator patients 显示文摘 | Man S De Winter PV Maan AC | 2011 | J Eleetroear- diol2011，44，4： | 1 |
| 12 | Osteocalcin and matrix Gla protein: Vitamin k-dependent proteins in bone 显示文摘 | Hauschka PV Lian JB Cole DE | 1989 | Physiol Rev1989，69，： | 1 |
| 13 | Nanomaterials for reversion of multidrug resistance in cancer: a new hope for an old idea 显示文摘 | Conde J de la Fuente JM Baptista PV | 2013 | Front Pharmaco12013，25，4： | 1 |
| 14 | Predictivepower of T-wave alternans and of ventricular gradienthysteresis for the occurrence of ventricular arrhythmiasin primary prevention cardioverter-defibrillator patients显示文摘 | Man S De Winter PV Maan AC | 2011 | J Electrocardiol2011，44，4： | 1 |
| 15 | Stem cel s derived from human amniotic fluid contribute to acute kidney injury recovery显示文摘 | Hauser PV De Fazio R Bruno S | | 0，，04： | 1 |
| 16 | Fiber post etching with hydrogen peroxide: effect of concentration and application time显示文摘 | de Sousa Menezes M Queiroz EC Soares PV et aI | 2011 | J Endod2011，37，3： | 1 |
| 17 | Volumetric capnography and chronic obstructive pulmonary disease staging显示文摘 | Romero PV Rodriguez B de Oliveira D | | 0，，： | 1 |
| 18 | Spatial relational memory requires hippocampal adult neurogenesis显示文摘 | Dupret D Revest JM Koehl M Ichas F De Giorgi F Costet P Abrous DN Piazza PV | 2008 | PLoS ONE2008，3，： | 1 |
| 19 | Detection of vasopressin cell antibodies in some patients with autoimmune endocrine diseases without overt diabetes insipidus显示文摘 | Bizzarro A Amoresano PV | 1994 | Clin Endocrinol1994，40，2： | 1 |
| 20 | International Conference for the Development of a Consensus on the Manage?ment and Prevention of Severe Candidal Infections显示文摘 | EdwardsJ Bodey G Pv Bowden R Av Buchner T de Pauw BE Filler S G | 1997 | Clin Infect Dis1997，25，： | 1 |
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