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1Therapeutic options for HER-2 positive breast cancer: Perspectives and future directions显示文摘During the last 15 years we have witnessed an unprecedented expansion in the drugs developed to target human epidermal growth factor receptor-2(HER-2) positive breast cancer. Trastuzumab, pertuzumab, adotrastuzumab emtansine and lapatinib are currently food and drug administration(FDA)-approved for the treatment of breast cancer patients with HER-2 overexpressed. However, given the amount of information gathered from years of uninterrupted clinical research, it is essential to have periodic updates that succinctly recapitulate what we have learnt over these last years and help us to apply that information in our daily practice. This review will pursue that objective. We will summarize the most relevant and updated informationrelated to the state of the art management of HER-2 positive breast cancer in all the clinical scenarios including the adjuvant, neoadjuvant and metastatic settings. But we will also critically appraise that literature in order to highlight some key clinical concepts that should not be overlooked. Lastly, this review will also point out some of the most promising strategies that are currently being tested and may soon become available.Gonzalo Recondo Jr Enrique Dìaz Canton Màximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi 2014World Journal of Clinical Oncology2014,5,3:7
2Medications as a Potential Source of Exposure to Phthalates in the U.S. Population显示文摘Hernández-Díaz Sonia Mitchell Allen A Kelley Katherine E Calafat Antonia M Hauser Russ 2009Environmental Health Perspectives2009,,2:2
3A prospective evaluation of CT features predictive of intra-abdominal hypertension and abdominal compartment syndrome in critically ill surgical patients显示文摘Bahrania AZ Abida GH Sahgala E 2007Clin Radiol2007,62,7:1
4CD4^+CD25^+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells显示文摘Suri-Payer E Amar AZ Thornton AM 1998J Immunol1998,160,3:1
5Effect of music on anxiety, stress, and depression levels in patients undergoing coronary angiography显示文摘Moradipanah F Mohammadi E Mohammadil AZ 2009East Mediterr Health J2009,15,:1
6Lower-limb robotic rehabilitation: literature review and challenges显示文摘DAZ I GIL J J SNCHEZ E 2011Journal of Robotics2011,2011,75:1
7Integrating short turning and deadheading in the optimization of transit services显示文摘Cortéés C E Jara-Díaz S Tirachini A 2011Transportation Research Part A:Policy and Practice2011,45,5:1
8Ethanolic ex- tract of Polish propolis: chemical composition and TRAIL - R2 death receptor targeting apoptotic activity against prostate cancer ceils 显示文摘Szliszka E Sokol - Letowska A Kucharska AZ 2013Evidence- based Complementary and Alternative Medicine2013,2013,75:1
9Comparison of ambulatory blood pressure and task force criteria to identify pediatric hypertension显示文摘Díaz L N Garin E H 2007Pediatr Nephrol2007,22,4:1
10Effect of the K + (ATP)channel opener, KCO912, on baseline and allergen i ndueed ai rway hyperre -sponsiveness in allergic rabbits 显示文摘E 1 - Hashim AZ Buchheit KH Fozard J 2004Eur J Pharmacol2004,484,23:1
11Alternatively sliced RAGEv1 inhibits tumorigenesis though suppression of JUK signaling显示文摘Kalea AZ See F Haria E 0,,13:1
12A review of chemical,electrochemical and biological methods for aqueous Cr(VI)reduction显示文摘BARRERA-DAZ C E LUGO-LUGO V BILYEU B 2012Journal of Hazardous Materials2012,223,:1
13Mechanisms of bacterial resistance to chromium compounds显示文摘Ramírez-Díaz MI Díaz-Pérez C Vargas E 2008Biometals2008,21,3:1
14Building Recognition from Multi aspect High Resolution InSAR Data in Urban Areas显示文摘Thiele A Cadario E Schulz K et aZ 2007IEEE Transactions on Geoscience and Remote Sensing2007,45,11:1
15Role of telehealth/videoconferencing in managing cancer pain in rural American Indian communities显示文摘Haozous E Doorenbos AZ Demiris G 2012Psychooncology2012,21,:1
16Evaluation of Metarhiziumanisopliae ( Hyphomycetes) for the control of Boophilus microplus(Acari :Ixodidae) onnaturally infested cattle in the Mexicantropics显示文摘ALONSO- DíAZ MA GARCíA L GALINDO- VELASCO E 2007Vet Parasitol2007,147,34:1
17Arterial recanalisation in acute stroke by means of a self-expanding stent显示文摘Guimaraens-Martinez G Vivas-Díaz E Sola-Martínez T 2009Rev Neurol2009,48,:1
18显示文摘Suarez P AZ SelbachVM LdulliusJ E 1997Electrochim Acta1997,42,16:1
19Failure modes and effects analysis in the prescription, validation and dispensing process显示文摘Delgado Silveira E Alvarez Di az A P6 rez Mend ndez-Conde C et al 2012Farm Hosp2012,36,1:1
20Microbiota of the cecum, ileum morphometry,pH of the crop and performance of broiler chickens supplemented with probiotics 显示文摘Fonseca B B Beletti M E Silva M S et aZ 2010Revista Brasileira De Zootecnia2010,39,8:1
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