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| 1 | Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary显示文摘AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic, and colorectal cancers.METHODS: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin,zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC)and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21including 9 patients suffering from in situ colon cancer)cancer. Fifty-seven healthy subjects (in matched groups)for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.RESULTS: The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene,α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.CONCLUSION: Retinoids (as environmental factors)are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer. | Gyula Mózsik Gy(o|¨)rgy Rumi András D(o|¨)m(o|¨)t(o|¨)r Mária Figler Beáta Gasztonyi El(?)d Papp Alajos Pár Gabriella Pár József Belágyi Zoltán Matus Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 2 | Human papillomavirus type- distribution in vulvar and vallinal cancers and their assodated precur- sors显示文摘 | Smith JS gackes DIM Hoots BE el al | 2009 | Obstet Gynecol2009，113，4： | 1 |
| 3 | Long-term adverse effects of radiation ihhibition of restenosis 显示文摘 | Powers BE Thams HD Gillette EL | 1999 | Int J Radiat Oncol Biol Phys1999，45，： | 1 |
| 4 | Aggressive angiomyxoma:findings on CT and MR imaging显示文摘 | Outwater EK Marchetto BE Wagner ]3J el al | 1999 | AJR Am J Roentgenol1999，172，43： | 1 |
| 5 | Structural gene identification and mapping by DNA-mRNA hybrid-arrested cell-free translation显示文摘 | Paterson BM Roberts BE Kuff EL | 1977 | Proc Natl Acad Sci USA1977，74，10： | 1 |
| 6 | AMP-activaled prolein ki- nase, super metabolic regulator 显示文摘 | Kemp BE Staplcton D Campbell DJ el al | 2003 | Biochem Soc Trans2003，31，1： | 1 |
| 7 | Comparison of effect of BMP2, 4, and 6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma 显示文摘 | Sekiya I Larson BE Vuoristo JT el al | 2005 | Cell Tissue Res2005，320，2： | 1 |
| 8 | Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs:a study in surgical specimen and autopsy controls 显示文摘 | W eiler C Nedich AG Bachmeier BE el al | 2005 | Spine2005，30，1： | 1 |
| 9 | Mid-term resuits of endovascular aneurysm repair with branched and fenestrated endografts 显示文摘 | Muhs BE Verhoeven EL Zeebregts CJ | 2006 | J Vasc Surg2006，44，1： | 1 |
| 10 | Spindle cell Lipoma of the esophagus 显示文摘 | Razzak R Be dard EL Hunt I | 2009 | Eur J Cardiothorac Surg2009，35，3： | 1 |
| 11 | Radiosurgery of growth hormone-producing pituitary adenonms:factors associated with biochemical remission显示文摘 | Jacob JT Brown PD el al | 2007 | Neurosurgery2007，106，5： | 1 |
| 12 | Randomised controlled clinical trial to determine the effects of the use of birth balls during labour 显示文摘 | Delgado-Garcia BE Oris-Cortes MI Povede-Bemabcu A el al | 2012 | Enferm Clin2012，22，1： | 1 |
| 13 | Comparison of ustekinumab and etanercept for moderate-to-severe psoriasis显示文摘 | Griffiths CE Strober BE van de Kerkhof P el al | 2010 | N Engl J Med2010，362，2： | 1 |
| 14 | Phase III trial of carbopla- tin and paelitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer:a Gynecologic one- ology group study 显示文摘 | Ozols RF Bundy BN Greeb BE el al | 2003 | J Clin Oncol2003，21，17： | 1 |
| 15 | Iron overload aug ments the development of atherosclerotic lesions in rabits 显示文摘 | Araujo JA Romano EL Brito BE | 1995 | Arterioscler Thromb Vasc Biol1995，15，8： | 1 |
| 16 | Treatment of recurrent platinum resistant ovarian or peritoneal cancer with gemcitabine and doxorubicin A phase 1/11 trial of the Duget Sound Oncology Consortium (Psoc 1602)显示文摘 | Goff BA Thompson T Greer BE el al | 2003 | Am J Obstet Gynecol2003，188，6： | 1 |
| 17 | Late radiation injury to muscle and peripheral nerves显示文摘 | Gillette EL Mahler PA Powers BE | 1995 | Int J Radiat Oncol Biol Phys1995，31，5： | 1 |
| 18 | Fenestrated and branched stent-grafting after previous surgery provides a good alternative to open redo surgery显示文摘 | Verhoeven EL Muhs BE Zeebregts CJ | 2007 | Eur J Vasc Endovasc Surg2007，33，1： | 1 |
| 19 | Threaded endodontic dowels: effect of post design on incidence of root fracture 显示文摘 | Felton DA Webb EL Kanoy BE | 1991 | J Prosthet Dent1991，65，2： | 1 |
| 20 | Two-dimensional gel electrophoreses andim-munoblotting of Campylobacter outer membrane proteins 显示文摘 | 10 Dunn BE Blaser MJ Synder EL | 1987 | Infect Immune1987，55，7： | 1 |
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