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| 1 | Hepatitis B-related events in autologous hematopoietic stem cell transplantation recipients显示文摘AIM: To investigate the frequency of occult hepatitis B, the clinical course of hepatitis B virus (HBV) reactivation and reverse seroconversion and associated risk factors in autologous hematopoietic stem cell transplantation (HSCT) recipients. METHODS: This study was conducted in 90 patients undergoing autologous HSCT. Occult HBV infection was investigated by HBV-DNA analysis prior to transplantation, while HBV serology and liver function tests were screened prior to and serially after transplantation. HBV-related events including reverse seroconversion and reactivation were recorded in all patients. RESULTS: None of the patients had occult HBV prior to transplantation. Six (6.7%) patients were positivefor HBV surface antigen (HBsAg) prior to transplantation and received lamivudine prophylaxis; they did not develop HBV reactivation after transplantation. Clinical HBV infection emerged in three patients after transplantation who had negative HBV-DNA prior to HSCT. Two of these three patients had HBV reactivation while one patient developed acute hepatitis B. Three patients had anti-HBc as the sole hepatitis B-related antibody prior to transplantation, two of whom developed hepatitis B reactivation while none of the patients with antibody to HBV surface antigen (anti-HBs) did so. The 14 anti-HBs-and/or anti-HBc-positive patients among the 90 HSCT recipients experienced either persistent (8 patients) or transient (6 patients) disappearance of anti-HBs and/or anti-HBc. HBsAg seroconversion and clinical hepatitis did not develop in these patients. Female gender and multiple myeloma emerged as risk factors for loss of antibody in regression analysis (P < 0.05). CONCLUSION: Anti-HBc as the sole HBV marker seems to be a risk factor for reactivation after autologous HSCT. Lamivudine prophylaxis in HbsAg-positive patients continues to be effective. | zcan eneli Zübeyde Nur zkurt Kadir Acar Seyyal Rota Sahika Zeynep Aki Zeynep Arzu Yegin Münci Yagci Seren zenirler Gülsan Türkz Sucak | 2010 | World Journal of Gastroenterology2010，16，14： | 3 |
| 2 | The Determination of the Protonation Constants of A New Macrocyclic Dinucleating Ligand, BDBPH显示文摘The protonation constants of a new dinucleating 24-membered hexaazadiphenol macrocyclic ligand, BDBPH, were determined by potentiometric measurement at 25.0℃ and μ = 0.100 mol·L-1 (KCl). The species distributions of the deprotonated and protonated compounds in the pH range from 2 to 12 in aqueous solutions were also described. | Guo Qiang SHANGGUAN1*, Ning WANG1 , Hong En WANG1, Arthur E. MARTELL2 1Department of Chemistry, Jining Medical College, Jining 272013 2Department of Chemistry, Texas A&M University, College Station, Texas 77842 | 2001 | Chinese Chemical Letters2001，12，2： | 2 |
| 3 | Prevalence and associated metabolic factors of fatty liver disease in the elderly显示文摘 | Zhongli Wang Ming Xu Jianhong Peng Li Jiang Zhengguo Hu Hua Wang Shiqing Zhou Rui Zhou Michael Hultstr?m En Yin Lai | 2013 | Experimental Gerontology2013，，8： | 2 |
| 4 | The catalytic subunit of yeast telomerase显示文摘 | Counter CM Meyerson M Eaton EN | 2003 | Proc Nat Acad Sci USA2003，94，： | 1 |
| 5 | hEST2, the putative human telomerase catalytic subunit gene, is up regulated in tumor cells and during immortalization显示文摘 | Meyerson M Counter CM Eaton EN | 1997 | Cell1997，90，： | 1 |
| 6 | RANTES and MIP-lalpha activate stats in T cells显示文摘 | Wong M Fish EN | 1998 | J Biol Chem1998，273，1： | 1 |
| 7 | RNA interference against Hec1 inhibits tumor growth in vivo显示文摘 | Gurzov EN Izquierdo M | 2006 | Gene Ther2006，13，： | 1 |
| 8 | Intelligent agents, theory and practice 显示文摘 | WOOLDBRIGE M J J ENNINGS N R | 1995 | Knowledge Engineering Review1995，10，2： | 1 |
| 9 | hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization 显示文摘 | Meyerson M Counter CM Eaton EN | 1997 | Cell1997，90，4： | 1 |
| 10 | The human EGF-TM7 family: a postgenomic view 显示文摘 | Kwakkenbos M J Kop EN Stacey M | 2004 | Immunogenetics2004，55，10： | 1 |
| 11 | Phosphorylation of apolipoprotein-E at an atypical protein kinase CK2 PSD/E site in vitro 显示文摘 | Raftery M Campbell R Glaros EN | 2005 | Biochemistry2005，44，19： | 1 |
| 12 | Mice deficient for PDGF B show renal,cardiovascular,and hematological abnormalities显示文摘 | Levéen P Pekny M Gebre-Medhin S et a1 | 1994 | Genes Dev1994，8，16： | 1 |
| 13 | Telomerase activity is restored in human cells by ectopic expression of hTERT(hEST2), the catalytic subunit of telemetries 显示文摘 | Counter CM Meyerson M Eaton EN | 1998 | Oncogene1998，16，9： | 1 |
| 14 | Cytotoxicity of magnetite loaded polylactide, polylactide/glycolide particles and solid lipid nanoparticles (SLN) 显示文摘 | Müller RH Maaen S Weyhers H | 1996 | Int J Pharm1996，138，1： | 1 |
| 15 | Telomerase activity is restored in human cells by subunit of telomerase显示文摘 | Counter CM Meyerson M Eaton EN | 1998 | Oncogene1998，16，9： | 1 |
| 16 | Adverse Selection, Moral Hazard, and Grower Compliance with bt Corn Refuge 显示文摘 | Paul D Mitchell En John Zhu Terrance M Hurley | 2004 | Agricutural & Applied Economics2004，，10： | 1 |
| 17 | Use of a fluorimetric test for bovine alkaline phospatase to demonstrate under-pasteurisation of skimmed milk and cream显示文摘 | ANTIA M R MELODY H G GARETH EN D | 2004 | International Dairy Journal2004，14，： | 1 |
| 18 | Language as a tool for interacting minds显示文摘 | Tyl'en K Weed E Wallentin M Roepstorff A & Frith C | | 0，，01： | 1 |
| 19 | Clinical significance of the tumour capsule in the treatment of parotid pleomorphie adenomas 显示文摘 | McGurk M Renehan A Gleave EN | 1996 | Br J Surg1996，83，12： | 1 |
| 20 | Wholesale hepatocytic differentiation in the rat from ductular oval cells, the progeny of biliary stem cells显示文摘 | Golding M Lalani EN | 1997 | J Hepatol1997，26，： | 1 |
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