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| 1 | 米索前列醇和PG05配伍米非司酮终止早孕的临床多中心随机比较试验显示文摘本研究为一项由十个单位参加的多中心临床试验,随机比较了三种用药方案:1.米非司酮25mgQ12h×5+PG051mg阴道塞药(组Ⅰ),2.米非司酮,同前十米索600μg(组Ⅱ),3.米非司酮200mg+米索600μg(组Ⅲ)终止早孕的安全性、有效性和可接受性。结果显示完全流产率为94.22%(913/969),其中组Ⅲ为91.50%,明显低于组Ⅰ(95.22%)和组Ⅰ(96.12%)(P=0.025);失败率为1.65%(16/969),其中组Ⅲ为3.52%,显著高于组Ⅰ(1.37%)、组Ⅱ(0%)(P=0.001);不完全流产率为2.89%(28/969),失访(结局不明)率为1.24%(12/969),三组间均无明显差异(P>0.05);自应用PG至孕囊排出时间,三组分别为3.06±1.65,2.81±2.75,3.21±1.61h(X±SD),组Ⅱ稍短于其他两组,其差异有统计学意义(P<0.05);阴道出血持续时间和转经时间无明显组间差异(P>0.05)。90%以上的对象均对药物流产方法表示满意。结果提示米索配伍米非司酮的安全性、有效性和可接受性令人满意;米非司酮低剂量多次给药与米索有较好的协同作用。 | He Chang-hai Gao Er-sheng Chen Jun-hang Gu Jiang Gui You-lnn and Cao Feng-zhen et al.(Collabrating Grou) for Clinical Study on Misoprostol to induce Abortion, Shanghai, 200032) | 1994 | 生殖与避孕1994，14，1： | 47 |
| 2 | Tectonic evolution of the Dabieshan orogen: In the view from polyphase deformation of the Beihuaiyang metamorphic zone显示文摘The Beihuaiyang metamorphic zone was formed by the Early Mesozoic collision of the North and South China Blocks. It consisted of the Foziling and Luzhenguan complexes and was thought to have never afforded a deep subduction. A similar feature of the deformation in the Dabieshan UHP metamorphic rocks implies that these different tectonic units share the same geodynamic background. The early stage of deformation can be preserved on account of their relatively shallower subduction than that for UHP rocks. On the basis of an analysis of the geo- logical structure and geochronological results, five deformational stages have been recognized: a D1-Early compressional deformation which represents the continental subduction; a D2-Early exhumation deformation producing a syn-convergence exhumation; a D3-Main deformation, represented by an exhumation deformation with Late Triassic age; a D4-Doming and its margin extensional gravity collapse deformation and finally a D5-regional extensional deformation of Cretaceous that was mostly introduced by the migmatization and plutonism. | LIN Wei1, 2, Faure Michel3, WANG Qingchen1 & Arnaud Nicolas4 1. LTE, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China 2. Department of Earth and Planetary Sciences, Graduate School of Science, Nagoya University, Japan 3. ISTO, UMR CNRS 6113, Batiment Géosciences, Orléans Université d’Orléans, 45067 Orléans Cedex 2, France 4. UMR 6524 'Magmas et Volcans', 5 Rue Kessler, 63000 Clermont-Ferrand, France | 2005 | Science China Earth Sciences2005，48，7： | 25 |
| 3 | 外用人α1型基因工程干扰素治疗慢性宫颈炎673例疗效观察显示文摘1988年8月至1989年1月,本协作组使用长春生研所研制成功的二种不同剂量外用人α1型基因工程干扰素1×10~5IU/ml及1×10~6IU/ml治疗慢性宫颈炎673例,在一疗程后总有效率达84.3%及86.6%,较对照组卡那霉素及妇炎灵的66.3%及62.9%为高(P<0.005)。停药6个月后,干扰素治疗组总有效率上升至90.1%及95.7%,疗效仍高于卡那霉素组的69.5%(P<0.05)。对宫颈糜烂病例宫颈局部作拭子标本197份进行HPV—16DNA分子杂交,阳性率达41.6%,其中经干扰素治疗166例,其治疗前后的阳性率分别为41.6%及17.5%,说明干扰素对HPV—16有一定的抑制作用。推测它有可能是一种阻断宫颈癌发生的方法。 | Wang Dawan, et al Beijing Obstetrics and Genecology Hospital, Beijing | 1990 | 中国免疫学杂志1990，6，1： | 17 |
| 4 | Isolation and Identification of a Specific cDNA Mapping to the Bam HI-I2 and -LFragments within the Inverted Repeats ofUnique Long Re-gion (IRL) in the Genom e ofMarek′s Disease Herpesvirus (MDV) Oncogenic Strain Beijing-1显示文摘Objective\ To understand the transcription of BamHI L DNA fragment from genome of strong virulent GA strain of Marek′s disease herpesvirus (MDV) in lymphoblastoid tumor tissue induced by oncogenic strain Beijing 1 (a specific local strain in China) of MDV. Methods\ Two oligonucleotide primers were synthesized according to the reported sequence of \%meq\% gene an ideal oncogenic candidate and our previously determined sequence of BamHI L fragment of Marek′s disease herpesvirus (MDV), respectively. Reverse transcriptase PCR(RT PCR) assay was performed by using these primers and the mRNA as a template which was isolated from visceral lymphoblastoid tumors obtained from chickens artificially infected with strain Beijing 1 of oncogenic MDV. Southern blot molecular hybridization was further carried out to detect the product of RT PCR with digoxigenin labeled nucleotide probe from BamHI I2 and L fragment in the gene library of MDV strain GA, respectively. Results\ Two probes could simultaneously hybridize this cDNA amplified by RT PCR with a length of about 730 bp. Conclusion\ It is suggested that \%meq\% transcription could extend from the right hand end of BamHI I2 to the adjacent BamHI L, and the BamHI L region was likely to be transcribed in MDV induced lymphoblastoid tumors. | Lu Chun, Wu Jianping, Zhang Xunhai, et al. Lu Chun, Wu Jianping, Zhang Xunhai, et al. Department of Microbiology and Immunology, Nanjing Medical University, Nanjing\ 210029 Acta Universitatis Medicinalis Nanjing, 19(6):447 | 1999 | The Journal of Biomedical Research1999，23，2： | 13 |
| 5 | Nerve Growth Factor Prevents the Apoptosis-associated Increase in Acetylcholinesterase Activity after Hydrogen Peroxide Treatment by Activating Akt显示文摘Acetylcholinesterase (疼痛) 被认为玩结果显示出的重要角色 duringapoptosis.Our 那 H_2O_2 导致了疼痛活动,功能的标记 inapoptosis,象 neuronal 一样 PC 12 房间的增加。谷胱甘肽,涉及细胞的氧化还原作用动态平衡,禁止了疼痛活动的增加,建议在这个过程的那个反应的氧种类(ROS ) 千盐湖钥匙角色。进一步的调查证明疼痛的举起在 Akt,从进 cytosol 的线粒体的细胞色素 c 的版本,和 caspase 家庭成员的激活的降级以后被观察。神经生长因素(NGF ) 什么时候是在场的,与 Akt 水平,疼痛的举起,细胞色素 c 散开,以及 apoptosis 的维护,显著地在对待 H_2O_2 的 PC12 细胞被稀释。然而, wortmannin, PI3K/Aktpathway 的一个禁止者,加速了 apoptosis 并且增加了疼痛活动。过去表示 ofconstitutively 激活 Akt,它是 NGF receptorTrkA,推迟的 mitochondrial 倒塌和疼痛活动的禁止的举起的一个下游的发信号元素。因此, NGF preventedapoptosis 和由激活 Akt 小径并且稳定线粒体的功能的疼痛活动的举起。 | Hua JIANG~(1,3) Jingya ZHANG~(1,3) Hui ZHU~(1,3) Hong LI~2 and Xuejun ZHANG~1 ~1Laboratory of Molecular Cell Biology,Institute of Biochemistry and Cell Biology,Shangha Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China ~2DEFEMA,Faculté de Medecine et de Pharmacie,University of Rouen,Rouen 76821,France ~3Graduate school of the Chinese Academy of Sciences,Beijing 100080,China | 2007 | Acta Biochimica et Biophysica Sinica2007，39，1： | 9 |
| 6 | Fura-2/AM法测定突触体内游离Ca^(2+)浓度的方法显示文摘采用新型Ca2+荧光指示剂Fura-2,测定冷冻伤性脑水肿时突触体内游离钙的离子浓度。 | Chen Liuhua Yan Yujia He Zhengwen, et al(Neurological and Neurosurgical Institute of Ncurosurgery, Xiangya Hospital, Hunan Medical University, Changsha 410008) | 1998 | 湖南医科大学学报1998，23，4： | 9 |
| 7 | Study on expresion of adherent proteins related to regulation of hematopoiesis in long-term cultured human bone marrow stromal cells显示文摘Studyonexpresionofadherentproteinsrelatedtoregulationofhematopoiesisinlongtermculturedhumanbonemarrowstromalcels.LiuJiewen,... | Liu Jiewen, Qi Shuling, E de Wynter, et al. Institute of Hematology, CAMS and PUMC, Tianjin 300020, China. | 1998 | Chinese Medical Journal1998，，2： | 8 |
| 8 | Hemodynamic Effects of Inhaled Nitric Oxide in Patients with Pulmonary Hypertension.显示文摘Twelve patients with pulmonary hypertension (primary pulmonary hypertension in 3 cases, secondary to recurrent pulmonary embolism in 4 cases, chronic obstructive pulmonary disease in 2 cases and complicated with congeni- | Zhao Yiju et al. Cardiovascular Institute and Fu Wai Hospital. CAMS Beij- ing 100037. National Medical Journal of China. | 1995 | Chinese Medical Journal1995，，9： | 7 |
| 9 | 流脑流行与人群抗体水平及带菌状况关系之探讨显示文摘通过80年代流脑流行周期的系统观察,首次阐明流脑流行与人群抗体水平及带菌状况之相关关系。观察结果显示,当流脑疫情处于散发期,流脑发病率及人群带菌率均处于低水平,人群流脑抗体水平也随之下降。当抗体水平降到低水平时。人群带菌率、流脑发病开始上升.然后抗体水平也随之升高.使用A群脑膜炎多糖菌苗免疫人群后,抗体水平显著上升,流脑发病、人群带菌明显下降。了解了这种变化规律,可早期观察流脑流行趋势,有利于采取各种防疫措施,指导流脑菌苗的接种工作,提高菌苗接种的经济效益。 | WuGuei kuen et al,(Collaboration Group of 7 Provincial Sanitary and Anti-epidemic Stations and Institute of Epidemiology and Microbiology(Beijing 100000) | 1994 | 中国公共卫生学报1994，13，4： | 6 |
| 10 | A群脑膜炎多糖菌苗接种前后流脑流行规律的改变及今后预防对策显示文摘本文研究了在使用菌苗预防前后的流行性脑脊髓膜炎流行强度的变迁,年龄、地区及季节分布特点,人群的易感性及带菌率之间的关系,并讨论了今后的预防措施。 | Wu Gueikuens, et al., Collaboration of 7 Provincial Sanitary and Anti-epidemic Station and Institute of Epidemiology and Microbiology (Beijing 100000) | 1994 | 中国公共卫生学报1994，13，5： | 5 |
| 11 | Radioimmunoscintigraphy of experimental arterialthrombi in dogs with ^(99m)Tc labelled chimeric monoclonal antibody against human activated platelets SZ-51 Hu显示文摘Radioimmunoscintigraphyofexperimentalarterialthrombiindogswith99mTclabeledchimericmonoclonalantibodyagainsthumanactivatedpla... | Zhang Wei, Wu Jinchang, He Guangren, et al. Thrombosis and Hemostasis Research Unit, The First Affiliated Hospital, Suzhou Medical College, Jiangsu Institute of Homatology, Suzhou 215006, China. | 1998 | Chinese Medical Journal1998，，3： | 5 |
| 12 | A群多糖脑膜炎菌苗最适免疫剂量的研究显示文摘近些年来对A群多糖脑膜炎菌苗最适免疫剂量进行了一系列现场流行病学及血清学效果的对比研究。首先肯定了我国生产的菌苗与法国Merieux研究所生产的苗苗在人体接种后观察一年内具有同等杀菌抗体反应。以后在严格对比下观察了国内生产的多糖菌苗接种30μg及50μg一年内的血清杀菌抗体反应。结果完全相同;而全身反应则30μg为50μg剂量的五分之一。在我国80年代流脑流行地区内确证了30μg免后人群保护率为99%与国外50μg的保护率(97.2%)相似。国内连续三年在流行地区内对比观察了30μg、与50μg的流行病学预防效果,其人群保护率相似.与国外(Reingold).的报告亦相似。最后结论是本菌苗的最适免疫剂量为30μg.不但其预防效果与50μg相同,而且菌苗反应轻微,经济效益高,有利于在发展中国家推广使用。 | Hu Zhen,et al.,(Collaboration .Croup of 7 Provincial Sanitary and Anti-epidemic Stations and Institute of Epidemiology and Microbiology) | 1994 | 中国公共卫生学报1994，13，3： | 3 |
| 13 | Clinical Observation on 57 Cases with Medical Amenorrhea Treated by Acupuncture显示文摘ClinicalObservationon57CaseswithMedicalAmenorrheaTreatedbyAcupuncture￥MaRen;Haijiping;Shagiae;etal.(TheFirstScientificInstitu... | Ma Ren Hai jiping Sha giae et al.(The First Scientific Institue of Acupunture and Moxibustion Shandong Jinan,250014) | 1995 | 中国针灸1995，15，S2： | 3 |
| 14 | Pandemic influenza 2009: Impact of vaccination coverage on critical illness in children, a Canada and France observational study显示文摘AIM To study the impact of vaccination critical illness due to H1N1pdm09, we compared the incidence and severity of H1N1pdm09 infection in Canada and France.METHODS We studied two national cohorts that included children with documented H1N1pdm09 infection, admitted to a pediatric intensive care unit(PICU) in Canada and in France between October 1, 2009 and January 31, 2010.RESULTS Vaccination coverage prior to admission to PICUs was higher in Canada than in France(21% vs 2% of children respectively, P < 0.001), and in both countries, vaccination coverage prior to admission of these critically ill patients was substantially lower than in the general pediatric population(P < 0.001). In Canada, 160 children(incidence = 2.6/100000 children) were hospitalized in PICU compared to 125 children(incidence = 1.1/100000) in France(P < 0.001). Mortality rates were similar in Canada and France(4.4% vs 6.5%, P = 0.45, respectively), median invasive mechanical ventilation duration and mean PICU length of stay were shorter in Canada(4 d vs 6 d, P = 0.02 and 5.7 d vs 8.2 d, P = 0.03, respectively). H1N1pdm09 vaccination prior to PICU admission was associated with a decreased risk of requiring invasive mechanical ventilation(OR = 0.30, 95%CI: 0.11-0.83, P = 0.02).CONCLUSION The critical illness due to H1N1pdm09 had a higher incidence in Canada than in France. Critically ill children were less likely to have received vaccination prior to hospitalization in comparison to general population and children vaccinated had lower risk of ventilation. | Olivier Fléchelles Olivier Brissaud Robert Fowler Thierry Ducruet Philippe Jouvet the Pediatric Canadian Critical Care Trials Group H1N1 Collaborative and Groupe Francophone de Réanimation et Urgences Pédiatriques | 2016 | World Journal of Clinical Pediatrics2016，5，4： | 2 |
| 15 | sinensis: regeneration and characterization of hybrid shoots显示文摘 | XU X Y HU Z Y LI J F et aL Asymmetric somatic hybridization between UV-irradiated Citrus unshiu and C | 2007 | Plant Cell Reports2007，26，： | 1 |
| 16 | Modulation of inflammatory response by hippocampus of rats exposed to cerebral ischemia/reperfusion显示文摘 | Coll the PPAR ino M Aragno M Ma oxidative stress -gamma agonists in stro and the cola R et a7 | 2006 | Eur J Pharmacol2006，530，： | 1 |
| 17 | Cytoskeletal remodeling 显示文摘 | Wang X Li F Campbell SE et ak Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: Ⅱ | 1999 | J Mol Cell Cardiol1999，31，： | 1 |
| 18 | The Canadian Critical Trials Group显示文摘 | Heyland DK Cook DJ Griffith L et aL The attributable morbidity and mortality of ventilator-associated pneumonia in the critically ill patient | 1999 | American Journal of Respiratory and Critical Care Medicine1999，159，41： | 1 |
| 19 | 50 carotenoids, sarcinaxanthin, sar- cinaxanthin monoglucoside, and sarcinaxanthin diglucoside, ob- tained from Mlerococcm yunnanen~la 显示文摘 | Osawa A Ishii Y Sasamura N et aL Characterization and an- tio~ddative activities of rare C | 2010 | J Oleo Sci2010，59，12： | 1 |
| 20 | The Cancer and Steroid Hormone Study Group显示文摘 | McDivitt RW Stevens JA Lee NC et aL Histologic types of be- nign breast disease and the risk for breast cancer | 1992 | Cancer1992，69，： | 1 |
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