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| 1 | Pandemic influenza 2009: Impact of vaccination coverage on critical illness in children, a Canada and France observational study显示文摘AIM To study the impact of vaccination critical illness due to H1N1pdm09, we compared the incidence and severity of H1N1pdm09 infection in Canada and France.METHODS We studied two national cohorts that included children with documented H1N1pdm09 infection, admitted to a pediatric intensive care unit(PICU) in Canada and in France between October 1, 2009 and January 31, 2010.RESULTS Vaccination coverage prior to admission to PICUs was higher in Canada than in France(21% vs 2% of children respectively, P < 0.001), and in both countries, vaccination coverage prior to admission of these critically ill patients was substantially lower than in the general pediatric population(P < 0.001). In Canada, 160 children(incidence = 2.6/100000 children) were hospitalized in PICU compared to 125 children(incidence = 1.1/100000) in France(P < 0.001). Mortality rates were similar in Canada and France(4.4% vs 6.5%, P = 0.45, respectively), median invasive mechanical ventilation duration and mean PICU length of stay were shorter in Canada(4 d vs 6 d, P = 0.02 and 5.7 d vs 8.2 d, P = 0.03, respectively). H1N1pdm09 vaccination prior to PICU admission was associated with a decreased risk of requiring invasive mechanical ventilation(OR = 0.30, 95%CI: 0.11-0.83, P = 0.02).CONCLUSION The critical illness due to H1N1pdm09 had a higher incidence in Canada than in France. Critically ill children were less likely to have received vaccination prior to hospitalization in comparison to general population and children vaccinated had lower risk of ventilation. | Olivier Fléchelles Olivier Brissaud Robert Fowler Thierry Ducruet Philippe Jouvet the Pediatric Canadian Critical Care Trials Group H1N1 Collaborative and Groupe Francophone de Réanimation et Urgences Pédiatriques | 2016 | World Journal of Clinical Pediatrics2016，5，4： | 2 |
| 2 | Pathophysiology of acute pancre-atitis 显示文摘 | Bhatia M Wong FL Cao Y et a 1 | 2005 | Pancreatology2005，5，23： | 1 |
| 3 | Association between HLA and Stevens-Johnson syndrome induced by carbamazepine in SouthernHan Chinese: genetic markers besides B*1502?显示文摘 | SHI YW MIN FL QIN B et ol | 2012 | Basic Clin Pharmacol Toxicol2012，111，1： | 1 |
| 4 | Corrdinated strategies for controlling micronutrient malnutrition:a technical workshop显示文摘 | Trowbridge FL Harris SS Cook J et a1 | 1993 | J Nutr1993，123，4： | 1 |
| 5 | Thyriod dysfunc- tion in patients with type 2 diabetes mellitus in Jordan显示文摘 | Radaideh AR Nusier MK Amari FL et a l | 2004 | Saudi Med J2004，25，9： | 1 |
| 6 | HLA-B alleles and lamotrigine- induced cautaneous adverse drug reaction in Han Chinese populations显示文摘 | SHI YW MIN FL LIU XR et 01 | 2011 | Basic Clin Pharmacol Toxicol2011，109，1： | 1 |
| 7 | A constitutively active and uninhibitable caspase-3 zymogen effieiently induces apoptosis 显示文摘 | Walters J Pop C Scott FL et d | 2009 | Biochem J2009，424，3： | 1 |
| 8 | High-frequency oscillatory ventilation in experimental lung injury,effects on gas exchange显示文摘 | Dembinski E Max M Bensberg Fl et aI | 2008 | lntensive Care Med2008，28，6： | 1 |
| 9 | Therapeutic options in advanced laryngeal cancer: an overview 显示文摘 | Dias FL Lima RA Kligerman J et at | 2005 | ORL J Otorhinolaryngol Relat Spec2005，67，6： | 1 |
| 10 | N16-5显示文摘 | Ma Y H Xue Y F Dou Y T et ah Characterization and gene cloning of a novel fl mannanase from alkaliphilic Bacillus sp | 2004 | Extremophiles2004，8，： | 1 |
| 11 | Cellular and molecular mechanisms in chronic obstructive pulmonary disease:an overview显示文摘 | Di Stefano A Caramori G Ricciardolo FL et a/ | 2004 | Clin Exp Allergy2004，34，2： | 1 |
| 12 | Cervicitis aeti- ology and case definition: a study in Australian women at- tending sexually transmitted infection clinics显示文摘 | Lusk MJ Garden FL Rawlinson WD et a/ | 2016 | Sex Transm Infect2016，92，3： | 1 |
| 13 | Is insomnia a marker for psychiatric disorders in general hospitals? 显示文摘 | Rocha FL Hara C Rodrigues CV et aL | 2005 | Sleep Med2005，6，： | 1 |
| 14 | Dimer formation drives the activation of the cell death protease caspase -9显示文摘 | Reantus M Stennicke HR Scott FL et ol | 2001 | Proc Natl Acad Sci USA2001，98，14： | 1 |
| 15 | Heparin-functionalized chitosan- alginate scaffolds for controlled release of growth factor显示文摘 | Ho YC Mi FL Sung HW et am | 2009 | lnt JPharm2009，376，： | 1 |
| 16 | Minimally invasive lateral lumbar interbody fusion and transpsoas approach-related morbidity显示文摘 | Moller DJ Slimack NP Acosta FL Jr et a1 | 2011 | Neurosurg Focus2011，31，4： | 1 |
| 17 | XIAP inhibits caspase-3 And-7 using two binding sites: Evolutionarily conserved mechan-ism of IAPs显示文摘 | Scott FL Denault JB Riedl S J et aL | 2005 | EMBO J2005，24，3： | 1 |
| 18 | Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance 显示文摘 | Kelley DE Thaete FL Troost F et ai | 2000 | Am J Physiol Endocrinol Metab2000，278，5： | 1 |
| 19 | B-type natriuretic pep-tide:beyond a diagnostic显示文摘 | Martin FL Chen HH Cataliotti A et a1 | | 0，，4： | 1 |
| 20 | Fabrication and characterization of asponge-like asymmetric chitosan membrane as a wound dressing显示文摘 | Mi FL Shin S Sh Y et a1 | 2001 | Biomaterials2001，22，2： | 1 |
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