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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | The trustworthy digital camera:restoring credibility to the photographic image显示文摘 | FRIEDMAN G L | 1993 | IEEE Transactions on Consumer Electronics1993，39，10： | 1 |
| 3 | Low-power repeaters driving RC and RLC interconnects with delay and bandwidth constraints 显示文摘 | Chen G Q Friedman E G | 2006 | IEEE Transactions on Very Large Scale Integration (VLSI) Systems2006，14，2： | 1 |
| 4 | Deep-burial dolomitization in the Ordovician Ellenburger Group carbonates,West Texas and Southeastern New Mexico显示文摘 | Lee Y I Friedman G M | 1987 | Journal of Sedimentary Research1987，57，3： | 1 |
| 5 | The putative tumor suppressor micro-RNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2显示文摘 | Friedman JM Liang G Liu CC | 2009 | Cancer Res2009，69，6： | 1 |
| 6 | Evaluation of meta-astatobenzylguanidine in an athymic mouse human neuroblastoma xenograft model显示文摘 | Vaidyanathan G Friedman HS Keir ST | 1996 | Nucl Med Biol1996，23，： | 1 |
| 7 | Kruppel cripples prostate cancer:KLF6 progress and prospects显示文摘 | Narla G Friedman SL Martignetti JA | 2003 | Am J Pathol2003，162，4： | 1 |
| 8 | Pharmacological stimulation of the cholinergic antiinflammatory pathway显示文摘 | Bernik Thomas R Friedman Steven G Ochani Mahendar | 2002 | J Exp Med2002，195，6： | 1 |
| 9 | Generalized peisach model of hysteresis (Invited) 显示文摘 | Mayergoyz I D Friedman G | 1988 | IEEE Trans on Magnetics1988，24，1： | 1 |
| 10 | The pharmacodynamic effects of sirolimus and sirolimus- calcineurin inhibitor combinations on macrophage scavenger and nuclear hormone receptors 显示文摘 | MATHIS A S JIN S FRIEDMAN G S | 2007 | J Pharm Sci2007，96，1： | 1 |
| 11 | Natural Language Processing and its Future in Medicine显示文摘 | Friedman C and Hripcsak G | 1999 | Journal of Academic Medicine1999，74，8： | 1 |
| 12 | Important causes of visual impairment in the world today显示文摘 | Congdon N G Friedman D S Lietman T | 2003 | JAMA2003，290，15： | 1 |
| 13 | Resolution of maxillary sinus mucositis after endodontic treatment of maxillary teeth with apical periodontitis: a cone-beam computed tomography pilot study显示文摘 | Nurbakhsh B Friedman S KUlkarni G V | 2011 | J Endod2011，37，11： | 1 |
| 14 | Now there are many (stages) where before there was one: in search of a pathophysiological classification of cirrhosis显示文摘 | Garcia-Tsao G Friedman S Iredale J | 2010 | Hepatology2010，51，4： | 1 |
| 15 | ORION:Clearing near-earth space debris using a 20 kW,530 nm,earth-based,re- petitively pulsed laser显示文摘 | Phipps C R Albrecht G Friedman H | 1996 | Laser and Particle Beams1996，14，1： | 1 |
| 16 | Information Needs and Information Seeking in Community Medical Education显示文摘 | Cogdill K W Friedman C P Jenkins C G | 2000 | Academic Medicine2000，75，5： | 1 |
| 17 | Kruppel crip- ples prostate cancer : KLF6 progress and prospects 显示文摘 | Narla G Friedman S L Martignetti J A | 2003 | AmJ Pathol2003，162，4： | 1 |
| 18 | Combined measurements of blood lactate concertrantions and gastric intramucosal pH in patients with sepsis 显示文摘 | FRIEDMAN G BERLOT G KAHN R J | 1995 | Crit Care Med1995，23，7： | 1 |
| 19 | Interventions for angle-closure glaucoma:an evidence-based update显示文摘 | Saw SM Gazzard G Friedman DS | | 0，，： | 1 |
| 20 | Femtosecond laser capsulotomy显示文摘 | FRIEDMAN N J PALANKER DV SCHUELE G ANDERSEN D MARCELLINO G SEIBEL BS | 2011 | J Cataract Refract Surg2011，37，7： | 1 |
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