|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Oxidative stress and extracellular matrices after hepatectomy and liver transplantation in rats显示文摘AIM:To investigate oxidative stress(OS)-mediated damage and the behavior of extracellular matrices in various rat models because shear stress with portal hypertension and cold ischemia/warm reperfusion injury trigger the liver regeneration cascade after surgery. These injuries also cause fatal liver damage.METHODS: Rats were divided into four groups according to the surgery performed: control; hepatectomy with 40% liver remnant(60% hepatectomy); orthotopic liver transplantation(OLT) with whole liver graft(100% OLT); and split OLT(SOLT) with 40% graft(40% SOLT). Survival was evaluated. Blood and liver samples were collected at 6 h after surgery. Biochemical and histopathological examinations were performed. OSinduced damage, 4-hydroxynonenal, ataxia-telangiectasia mutated kinase, histone H2AX, phosphatidylinositol 3-kinase(PI3K) and Akt were evaluated by western blotting. Behavior of extracellular matrices, matrix metalloproteinase(MMP)-9, MMP-2, tissue inhibitor of metalloproteinase(TIMP)-1 and TIMP-2 were also evaluated by western blotting and zymography. RESULTS: Although 100% OLT survived, 60% hepatectomy and 40% SOLT showed poor survival. Histopathological, immunohistological, biochemical and protein assays revealed that 60% hepatectomy, 100% OLT and 40% SOLT showed liver damage. PI3K and Akt were decreased in 60% hepatectomy and 40% SOLT. For protein expression, 40% SOLT showed differences in MMP-9, MMP-2 and TIMP-2. TIMP-1 showed differences in 60% hepatectomy and 40% SOLT. For protein activity, MMP-9 demonstrated significant differences in 60% hepatectomy, 100% OLT and 40% SOLT. CONCLUSION: Under conditions with an insufficient liver remnant, prevention of OS-induced damage via the Akt/PI3K pathway may be key to improve the postoperative course. MMP-9 may be also a therapeutic target after surgery. | Tomohide Hori Shinji Uemoto Feng Chen Lindsay B Gardner Ann-Marie T Baine Toshiyuki Hata Takayuki Kogure Justin H Nguyen | 2014 | World Journal of Hepatology2014，6，2： | 7 |
| 2 | Simple and reproducible hepatectomy in the mouse using the clip technique显示文摘AIM: To investigate the reliability of massive hepatectomy models by using clip techniques. METHODS: We analyzed anatomical findings in 100 mice following massive hepatectomy induced by liver reduction > 70%. The impact of various factors in the different models was also analyzed, including learning curves, operative time, survival curves, and histopathological findings.RESULTS: According to anatomical results, models with 75%, 80%, and 90% hepatectomy produced massive hepatectomy. Learning curves and operative times were most optimal with the clip technique. Each hepatectomy performed using the clip technique produced a reasonable survival curve, and there were no differences in histopathological findings between the suture and clip techniques. CONCLUSION: Massive hepatectomy by the clip technique is simple and can provide reliable and relevant data. | Tomohide Hori Norifumi Ohashi Feng Chen Ann-Marie T Baine Lindsay B Gardner Toshiyuki Hata Shinji Uemoto Justin H Nguyen | 2012 | World Journal of Gastroenterology2012，18，22： | 4 |
| 3 | The Importance of Medial Support in Locked Plating of Proximal Humerus Fractures显示文摘 | Michael J Gardner Yoram Weil Joseph U Barker Bryan T Kelly David L Helfet Dean G Lorich | 2007 | Journal of Orthopaedic Trauma2007，，3： | 2 |
| 4 | Neutral models for the analysis of broad-scale landscape pattern显示文摘 | Gardner R H Mime B T Turner M G | 1987 | Landscape Ecology1987，1，1： | 2 |
| 5 | Hydrocompression settlement of deep fills 显示文摘 | Brandon T L Duncan J M Gardner W S | 1990 | ASCE Journal of Geotech Eng1990，116，10： | 1 |
| 6 | Modeling hydrology and reactive transport in roads: the effect of cracks, the edge, and contaminant properties显示文摘 | Apul D S Gardner K H Eighmy T T | 2007 | Science Direct Waste Management2007，27，： | 1 |
| 7 | The relationship between HR practices and firm performance : Examining causal order 显示文摘 | Wright P M Gardner T M Moynihan L M | 2005 | Personnel Psychology2005，58，2： | 1 |
| 8 | Hemoglobins dioxygenate nitric oxide with high fidelity显示文摘 | Gardner P R Gardner A M Brashear W T | 2006 | J Inorg Biochem2006，100，4： | 1 |
| 9 | Comprehensive fall prevention programs across settings: a review of the literature 显示文摘 | MacCulloch PA Gardner T Bonner A | 2007 | Geriatr Nurs2007，28，5： | 1 |
| 10 | The affect system has parallel and integrative processing components form follows function显示文摘 | CACIOPPO J T GARDNER W L BERNTSON G G | 1999 | Journal of Personality and Social Psychology1999，76，： | 1 |
| 11 | Authentic Leadership:Development and Validation of a Theo- ry-Based Measure显示文摘 | Walumbwa F Avolio B Gardner W L Wernsing T | 2008 | Journal of Management2008，34，1： | 1 |
| 12 | Probabilistic modeling of one-dimensional water movement and leaching from highway embankments containing secondary materials显示文摘 | Apul D S Gardner K H Eighmy T T | 2005 | Environmental Engineering Science2005，22，2： | 1 |
| 13 | Dynamic Analysis of Riser and Caissions by the Element Method显示文摘 | Gardner T N Kotch M A | 1976 | OTC 26511976，，3： | 1 |
| 14 | Controlled metallic nanopillars for low impedance biomedical electrode显示文摘 | GARDNER C J TRISNADI J KIM T K BRAMMER K REISS L CHEN L H J1N S | 2014 | Acta Biomaterialia2014，10，5： | 1 |
| 15 | A B-spline finite element method for the regularized long wave equation显示文摘 | Gardner L R T Gardner G A Dag I | 1979 | Comput methods Appl mecheng1979，20，： | 1 |
| 16 | Inferring genetic networks and identifying compound mode of action via expression profiling显示文摘 | GARDNER T S d BERNARDO D LORENZ D | | 0，，5629： | 1 |
| 17 | Integrating resilience thinking and optimization for conservation显示文摘 | Fischer J Peterson GD Gardner TA Gordon L J Fazey I Elmqvist T Felton A Folke C Dovers S | | 0，，： | 1 |
| 18 | Organizational socialization:Its content and consequences 显示文摘 | Chao G T O' Leary-Kelly A M Wolf S Klein H J Gardner P D | 1994 | Journal of Applied Psychol- ogy1994，79，5： | 1 |
| 19 | Preliminary investigation of breath sampling as a monitor of health in dairy cattle显示文摘 | Elliott-Martin R J Mottram T T Gardner J W | 1997 | Engng Res1997，，67： | 1 |
| 20 | Temperature development in structural stainless steel sections exposed to fire显示文摘 | GARDNER L NG K T | 2006 | Fire Safety Journal2006，41，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员