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| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | The structure, expression, and multifaceted role of immune-checkpoint protein VISTA as a critical regulator of anti-tumor immunity, autoimmunity, and inflammation显示文摘Among various immunoregulatory molecules,the B7 family of immune-checkpoint receptors consists of highly valuable targets for cancer immunotherapy.Antibodies targeting two B7 family co-inhibitory receptors,CTLA-4 and PD-1,have elicited long-term clinical outcomes in previously refractory cancer types and are considered a breakthrough in cancer therapy.Despite the success,the relatively low response rate(20–30%)warrants efforts to identify and overcome additional immune-suppressive pathways.Among the expanding list of T cell inhibitory regulators,V domain immunoglobulin suppressor of T cell activation(VISTA)is a unique B7 family checkpoint that regulates a broad spectrum of immune responses.Here,we summarize recent advances that highlight the structure,expression,and multi-faceted immunomodulatory mechanisms of VISTA in the context of autoimmunity,inflammation,and anti-tumor immunity. | Wenwen Xu TạMinh Hiếu Subramaniam Malarkannan Li Wang | 2018 | Cellular & Molecular Immunology2018，15，5： | 8 |
| 3 | Current treatment of pelvic ring fractures 显示文摘 | Culemann U Oestern HI Pohlemann T | 2013 | Chirurg2013，84，9： | 1 |
| 4 | Thymus andautoimm unity: production of CD4 + CD25 + naturally anerfgic and suppressive Tcells a sakey function Ofthethym us inmain taining immunologic self-tolerance 显示文摘 | Itoh M takahaS hi T S akaguch i | 1999 | J Immunol1999，162，9： | 1 |
| 5 | The predominant neural stem cell isolated from postnatal and adult forebrain but not early embryonic forebrain expresses GFAP显示文摘 | Imura T Komblum HI Sofroniew MV | | 0，，07： | 1 |
| 6 | The effects of de- xmedetomidine on liver ischemia-reperfusion injury in rats 显示文摘 | SAHIN T BEGEC Z TOPRAK HI | 2013 | Journal of Surgical Research2013，183，1： | 1 |
| 7 | Particulate contamination of lyophilized amphotericin B preparation during reconstitution process显示文摘 | Sendo T Hi rakawa M Makino K | 2001 | Journal of Clinical Pharmacy and Therapeutics2001，，2： | 1 |
| 8 | Ostegenic differentiation of hypertrophic chondrocytes involves asymmetric cell divisions and apoptosis显示文摘 | Roach HI Aigner T Erenpeisa J | 1995 | J Cell Biol1995，131，3： | 1 |
| 9 | Effect of growth factors on matrix synthesis by ligament fibroblasts 显示文摘 | Marui T Niyibizi C Georgescu HI | 1997 | J Orthop Res1997，15，2： | 1 |
| 10 | for gastrointestinal Laparoscopic and endoscopic cooperatire surgery stromal tumor dissection显示文摘 | Hi ki W Yamamoto Y Fukunaga T | 2008 | Surg Endosc2008，22，18： | 1 |
| 11 | Impurity-doped ZnO as a Substitute Material for ITO显示文摘 | Minamt T Kanazawa K Daigaku Hi | 2007 | Ceramics Japan2007，42，1： | 1 |
| 12 | Defining the E-cadherin repressor interactome in epithelial- mesenchymal transitions: the PMC42 model as a case study 显示文摘 | Hugo HI Kokkinos MI Bliek T | 2011 | Cell Tissues Organs2011，193，12： | 1 |
| 13 | Vulnerable atheroselerotic plaque: a muhifocal disease 显示文摘 | Casseelis W Naghavi hi Wilier son J T | 2003 | Circulation2003，107，： | 1 |
| 14 | Low-temperature Structure of V6 Oi3 显示文摘 | Hi wing J Gustafsson T Thomas J O | 2003 | Acta CrystaUographica Section B :Structural Science2003，，59： | 1 |
| 15 | Regulation of drought tolerance by gene manipulation of 9 -cis -epoxy - carotenoid dioxygenase, a key enzyme in abscisic acid biosynthesis in Arabidopsis 显示文摘 | Lu chi S Kobayas hi M Taji T | 2001 | Plant J2001，27，： | 1 |
| 16 | The forgotten ones?The validity of consideration and initiating structurein leadership research显示文摘 | Judge T A Piccolo R F Hies R | 2004 | Journal of Applied Psycholo-gy2004，89，1： | 1 |
| 17 | Iliac artery stenting in patients with poor distal runoff: influence of concomitant infrainguinal arterial reconstruction 显示文摘 | Timaran C Hi Ohki T Gargiulo N J | 2003 | J Vasc Surg2003，38，3： | 1 |
| 18 | Effect of growth factors on matrix synthesis by ligament fibroblasts 显示文摘 | Marui T Niyibizi C Georgescu HI | 1997 | J Orthop Res1997，15，1： | 1 |
| 19 | The Effects Of Induced Hypothermia On Pulmonary Endothelial Monolayer Hyperpermeability显示文摘 | Ghamloush M NS Hi Liu T | 2011 | Am J Respir Crit Care Med 20112011，3985，： | 1 |
| 20 | DNase SISPA-next generation sequencing confirms Schmallenberg virus in Bel- gian field samples and identifies genetic variation in Europe 显示文摘 | Rosseel T Scheueh hi HSper D | 2012 | PLoS One2012，7，41： | 1 |
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