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| 1 | Prognostic values of tumor endothelial markers in patients with colorectal cancer显示文摘AIM: Tumor endothelial markers (TEMs) are a newly discovered family of endothelial markers associated with tumor specificangiogenesis. This study sought to examine the levels of expression (qualitatively and quantitatively)for TEMs in human colon cancer.METHODS: Human colorectal cancer tissues (n = 48)and normal background tissues (n = 31) were obtained after surgery. RNA was extracted from frozen sections for gene amplification. The expression of TEMs (TEM-1to TEM-8) was assessed using RT-PCR and their transcript levels were determined using real-time-quantitative PCR(Q-RT-PCR).RESULTS: TEM-1 (P = 0.01), TEM-7 (P = 0.04), TEM-7R(P= 0.03), TEM-8 (P = 0.001) significantly raised in colon cancer tissues compared with the levels detected in normal background tissues. The expressions of TEM-2 and TEM-6were found to be not significantly different between tumor tissues and normal tissues (P>0.05). Patients who had cancer penetrating into and through the muscularis propria of the bowel wall and developed nodal involvement(Dukes C) exhibited significantly higher levels of TEM -8compared to patients who were node negative (P<0.05).TEM-7 and TEM-7R showed high level of transcripts in Dukes C, but they were not statistically significant.CONCLUSION: The level of the expression of TEM-1,TEM-7, TEM-7R and TEM-8 (but not TEM-2 and TEM-6)were associated with both nodal involvement and disease progression, and may therefore, have a prognostic value in colorectal cancer. | KA Rmali MCA Puntis WG Jiang | 2005 | World Journal of Gastroenterology2005，11，9： | 7 |
| 2 | E-cadherin and its associated protein catenins,carcinoma invasion and metastasis 显示文摘 | Jiang WG | 1996 | Br J Surg1996，83，4： | 2 |
| 3 | Cortical neurogenesis in adult rats after transient middle cerebral artery occlusion显示文摘 | Jiang W Gu WG Brannstrom T | 2001 | Stroke2001，32，： | 2 |
| 4 | Tamoxifen resistance in MCF7 cells promotes EMT-like behaviour and involves modulation of beta-catenin phosphorylation 显示文摘 | Hiscox S Jiang WG Obermeier K | 2006 | Int J Cancer2006，118，2： | 1 |
| 5 | Cell-cell adhesion molecules and signaling intermediates and their role in the invasive potential of prostate cancer cells显示文摘 | Davies G Jiang WG Mason MD | | 0，，： | 1 |
| 6 | KAI1/CD82, the molecule and clinical imphcation in cancer and cancer metastasis显示文摘 | Malik FA Sanders AJ Jiang WG | 2009 | Histol Histopathol2009，24，4： | 1 |
| 7 | The Coxsackie-adenovi- rus receptor has elevated expression in human breast cancer显示文摘 | Martin TA Watkins G Jiang WG | 2005 | Clin Exp Med2005，5，3： | 1 |
| 8 | Quantitative analysis of lymphangiogennicmarkers in human colorectal cancer 显示文摘 | Parr C Jiang WG | 2003 | Int J Oncol2003，23，2： | 1 |
| 9 | Differentail expression of the CCN family members Cyr61, CTGF and Nov in human breast cancer 显示文摘 | Jiang WG Watkins C Fodstad O | 2004 | Endocr Relat Cancer2004，11，4： | 1 |
| 10 | Molecular and cellular mechanisms of lymphangiogenesis 显示文摘 | J AI Rawi MA Mansel RE Jiang WG | 2005 | Euro J Surg Oncol2005，31，2： | 1 |
| 11 | Expression of autocrine motility factor (AMF) and its receptor,AMFR,in human breast cancer显示文摘 | Jiang WG Raz A Douglas-Jones A | 2006 | J Histochem Cytochem2006，54，2： | 1 |
| 12 | Lymphangiogenesis quantifieation using quantitative PCR and breast cancer as a model显示文摘 | Cunnick GH Jiang WG Gomez KF | 2001 | Biochem Biophys Res Commun2001，288，4： | 1 |
| 13 | Higher expression levels of SOCS 1,3,4,7 are associated with earlier turnout stage and better clinical outcome in human breast cancer显示文摘 | Sasi W Jiang WG Sharma A | 2010 | BMC Cancer2010，10，： | 1 |
| 14 | E-cadherin and associated molecules in the invasion and progression of prostate cancer显示文摘 | Jiang WG Mason MD | 1998 | Oncol Rep1998，5，6： | 1 |
| 15 | KiSS-1 expression in human breast cancer显示文摘 | Martin TA Watkins G Jiang WG | 2005 | Clin Exp Metastasis2005，22，6： | 1 |
| 16 | The expression of gene transcripts of telomere associated genes in human breast cancer: correlation with clinicopathological parameters and clinical outcome显示文摘 | Salhab M Jiang WG Newbold RF | 2008 | Breast Cancer Res Treat2008，109，1： | 1 |
| 17 | Enhancement of wound tissue expansion and angiogenesis by matrix-embedded fibroblast (dermagraft), a role of hepatocyte growth factor/scatter factor 显示文摘 | Jiang WG Harding KG | 1998 | Int J Mol Med1998，2，2： | 1 |
| 18 | Antagonistic effect ofNK4, a novel hepatocyte growth factor variant, on in vitro angiogenesis of human vascular endothelial cells显示文摘 | Jiang WG Hiscox SE Parr C et o/ | 1999 | Clin Cancer Res1999，5，2： | 1 |
| 19 | Hepatocyte growth factor, its receptor, and their potential value in cancer therapies 显示文摘 | Jiang WG Martin TA Parr C | 2005 | Hematology2005，53，1： | 1 |
| 20 | Expression of peroxisome-proliferator activated receptor-gamma (PPARgamma) and the PPARgamma co-activator, PGC-1, in human breast cancer correlates with clinical outcomes 显示文摘 | Jiang WG Douglas-Jones A Mansel RE | 2003 | Int J Cancer2003，106，5： | 1 |
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