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| 1 | Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells显示文摘Acute myeloid leukemia(AML)is a serious disease.The 5-year survival rates remain frustratingly low(65%for children and 26%for adults).Resistance to frontline chemotherapy(usually cytarabine)often develops;therefore a new treatment modality is needed.Bcl-2 family proteins play an important role in balancing cell survival and apoptosis.The antiapoptotic Bcl-2 family proteins have been found to be dysregulated in AML.ABT-199,a BH3 mimetic,was developed to target antiapoptotic protein Bcl-2.Although ABT-199 has demonstrated promising results,resistance occurs.Previous studies in AML show that ABT-199 alone decreases the association of proapoptotic protein Bim with Bcl-2,but this is compensated by increased association of Bim with prosurvival protein Mcl-1,stabilizing Mcl-1,resulting in resistance to ABT-199.In this study,we investigated the antileukemic activity of the Mcl-1-selective inhibitor A-1210477 in combination with ABT-199 in AML cells.We found that A-1210477 synergistically induced apoptosis with ABT-199 in AML cell lines and primary patient samples.The synergistic induction of apoptosis was decreased upon Bak,Bax and Bim knockdown.While A-1210477 treatment alone also increased Mcl-1 protein levels,combination with ABT-199 reduced binding of Bim to Mcl-1.Our results demonstrate that sequestration of Bim by Mcl-1,a mechanism of ABT-199 resistance,can be abrogated by combined treatment with the Mcl-1 inhibitor A-1201477. | Daniel A Luedtke Xiaojia Niu Yihang Pan Jianyun Zhao Shuang Liu Holly Edwards Kang Chen Hai Lin Jeffrey W Taub Yubin Ge | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 11 |
| 2 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 3 | 原位中子衍射研究两相NiTi合金的微力学相互作用和相变机理显示文摘NiTi合金的形状记忆效应与其微观结构特征密切相关,中子衍射技术可以在力学加载过程中原位观察块体NiTi合金的相变、晶间应变以及孪晶再取向等演化特征.结合两相NiTi合金宏观应力-应变曲线呈现的四种阶段性变形特征,利用原位中子衍射技术对其变形过程中的微观结构演化进行了分析.奥氏体初始体积份额约22%,在低应变硬化阶段,晶面(110)B2和(002)B19′的应变分别突然减小和增大表明出现了应力诱发马氏体相变,奥氏体体积份额迅速减小,产生了011Ⅱ型孪晶;同时初始马氏体也开始发生再取向,随着应变量的增加,开始出现新的{20ī}型马氏体孪晶,这种孪晶引起的应变卸载时不能回复.在高应变硬化阶段孪晶变形起主导作用,衍射峰半高宽变化较小;而在应变硬化饱和阶段则以滑移机制为主,大量位错的产生使衍射峰半高宽显著增加. | 孙光爱 王虹 汪小琳 陈波 常丽丽 刘耀光 盛六四 Woo W Kang MY | 2012 | 物理学报2012，61，22： | 4 |
| 4 | The structural basis of the dominant negative phenotype of the Gαi1β1Y2 G203A/A326S heterotrimer显示文摘 | Ping LIU Ming-zhu JIA X Edward ZHOU Parker W DE WAAL Bradley M DICKSON Bo LlU Li HOU Yan-ting YIN Ya n-yong KANG Yi SHI Karsten MELCHER H Eric XU Yi JIANG | 2016 | Acta Pharmacologica Sinica2016，37，9： | 3 |
| 5 | 血根碱对肉鸡生长性能、相对器官重量、盲肠菌群、血清胆固醇水平以及肉品质的影响显示文摘研究旨在探索日粮添加血根碱(SGV)对肉鸡生长性能、相对器官重量、盲肠菌群、血清胆固醇水平和腿肌丙二醛含量的影响。选用840日龄雄性肉鸡(罗斯品种)饲养于28个稻草垫上,随机分为4个处理:玉米-豆粕型基础对照日粮、基础日粮中添加卑霉素10 ppm作为生长促进剂(AGP)、基础日粮中添加SGV 20 ppm(SGV20)和50 ppm(SGV50)。与饲喂基础日粮的肉鸡相比,基础日粮中添加AGP组、SGV20组和SGV50组的肉鸡最终体重(BW)、日增重、饲料转化率(FCR)显著改善(P<0.05)。与对照组相比,SGV20喂养组的肉鸡相对空肠重量显著降低(P<0.05),所有添加SGV组肉鸡相对空肠或回肠长度显著升高(P<0.05)。SGV20组较对照组肉鸡肠道菌群有所改变,尤其是盲肠乳酸菌数增加,但AGP组无改变。SGV20组或SGV50组肉鸡的总胆固醇水平较对照组显著降低(P<0.05),控制饮食物显著降低(P<0.05)。添加SGV后,作为脂质过氧化反应指示剂的腿肌丙二醛含量显著降低(P<0.05)。研究表明,在肉鸡日粮中补充SGV 20或50 ppm可以提高肉鸡生长性能,改变多种生物和生理参数,如相对器官重量、血清胆固醇水平、肠道菌群和肉品质。 | Lee K W Kim J S Oh S T Kang C W An B K | 2015 | 饲料博览2015，0，3： | 2 |
| 6 | Lanthanum-substituted bismuth titanate for use in non-volatile memories 显示文摘 | PARK B H KANG B S NOH T W | 1999 | Nature1999，401，： | 2 |
| 7 | 分子束外延高Mg掺杂GaN的发光特性显示文摘采用分子束外延技术在蓝宝石衬底上制备Mg掺杂的立方相p-GaN,并对其不同温度下的光致发光光谱进行了研究.实验观察到高Mg掺杂GaN中施主受主对发光的反常温度行为.理论分析表明,高Mg掺杂GaN中施主受主对的发光受到陷阱与受主间竞争俘获非平衡空穴过程和空穴隧穿输运过程的影响. | 宋航 Park S H Kang T W Kim T W | 1999 | 发光学报1999，20，2： | 2 |
| 8 | 显示文摘 | Choi W B Chung D S Kang J H | 1999 | Applied Physics Letters1999，75，20： | 1 |
| 9 | Selection and validation of optimal siRNA target sites for RNAi-mediated gene silencing显示文摘 | LUO Q KANG Q SONG W X | 2007 | Gene2007，395，12： | 1 |
| 10 | Development of a vibratory potato digger for small farms显示文摘 | J L Halderson | 1991 | American Potato Journal1991，68，： | 1 |
| 11 | Low-loss fluorinated poly (arylene ether sulfide)waveguides with high thermal stability显示文摘 | KIM J P LEE W Y | 2001 | J Lightwave Teclmol2001，19，6： | 1 |
| 12 | Identification and characterization of the major allergens of buckwheat显示文摘 | PARK J W KANG D B KIM C W | 2000 | Allergy2000，55，11： | 1 |
| 13 | Inhaled nitric oxide attenuates acute lung injury via inhibition of nuclear factor-kappa B and inflammation显示文摘 | Kang JL Park W Pack IS | 2002 | J Appl Physiol2002，92，： | 1 |
| 14 | Essential role of phosphatidylinositol 3-kinase-dependent CCAAT/enhancer binding protein beta activation in the induction of glutathione S- transferase by oltipraz显示文摘 | Kang K W Cho I J Lee C H etal | 2003 | J Natl Cancer Inst2003，95，： | 1 |
| 15 | Effects of Reaction Conditions on the Oxidation Efficiency in the Fenton Process 显示文摘 | Kang Y W Hwang K Y | 2000 | Wat Res2000，34，10： | 1 |
| 16 | Retinal damage by light in rats显示文摘 | NOELL W K WALKER V S KANG B S | 1966 | Invest Ophthalmol Vis Sci1966，5，5： | 1 |
| 17 | Detection of pandemic influenza A/ H1N1/2009 virus by real-time reverse transcription polymerase chain reaction显示文摘 | Wu W Kang X Bai Z | 2010 | J Virol Methods2010，165，2： | 1 |
| 18 | The Strategic Effects of Multimarket Contact: Mutual Forbearance and Competitive Re- sponse in the Personal Computer Industry 显示文摘 | Kang W Bayus BL Balasubramanian S | 2010 | JOURNAL OF MARKETING RESEARCH2010，47，3： | 1 |
| 19 | Antimetastatic and antitumor effects of benzo- quinonoid AC7-1 from Ardisia crispa显示文摘 | KANG Y H KIM W H PARK M K | 2001 | Int J Cancer2001，93，5： | 1 |
| 20 | Solid polymer electrolytes based on cross- linked polysiloxane-g- oligo(ethylene oxide): ionic conductivity and electrochemical properties显示文摘 | Kang Y Lee W Suh D H | 2003 | J Power Sources2003，119，： | 1 |
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