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| 1 | Isolation of bacteria from fermented food and grass carp intestine and their efficiencies in improving nutrient value of soybean meal in solid state fermentation显示文摘Background: Soybean meal is an excellent and cost-effective protein source; however, its usage is limited in the piglet due to the presence of anti-nutritional factors and the antigens glycinin and β-conglycinin. The objective of the current study was to screen and select for bacteria that can be efficiently adopted to ferment soybean meal in order to solve this problem.Results: Bacteria were isolated from fermented soy foods and the grass carp intestine, and strains selected for high protease, cellulase and amylase activities. The isolated bacteria were characterized as Bacillus cereus, Bacillus subtilis and Bacilus amyloliquefacien, respectively. Fermentation with food-derived Isolate-2 and fish-derived F-9 increased crude protein content by 5.32% and 8.27%, respectively; improved the amino acid profile by increasing certain essential amino acids, broke down larger soy protein to 35 k Da and under, eliminated antigenicity against glycinin and β-conglycinin, and removed raffinose and stachyose in the soybean meal following a 24-h fermentation.Conclusions: Our results suggest these two B. amyloliquefaciens bacteria can efficiently solid state ferment soybean meal and ultimately produce a more utilizable food source for growing healthy piglets. | Samantha Medeiros Jingjing Xie Paul W.Dyce Hugh Y.Cai Kees De Lange Hongfu Zhang Julang Li | 2018 | Journal of Animal Science and Biotechnology2018，9，3： | 12 |
| 2 | Methodology to develop machine learning algorithms to improve performance in gastrointestinal endoscopy显示文摘Assisted diagnosis using artificial intelligence has been a holy grail in medical research for many years, and recent developments in computer hardware have enabled the narrower area of machine learning to equip clinicians with potentially useful tools for computer assisted diagnosis(CAD) systems. However, training and assessing a computer's ability to diagnose like a human are complex tasks, and successful outcomes depend on various factors. We have focused our work on gastrointestinal(GI) endoscopy because it is a cornerstone for diagnosis and treatment of diseases of the GI tract. About 2.8 million luminal GI(esophageal, stomach, colorectal) cancers are detected globally every year, and although substantial technical improvements in endoscopes have been made over the last 10-15 years, a major limitation of endoscopic examinations remains operator variation. This translates into a substantial inter-observer variation in the detection and assessment of mucosal lesions, causing among other things an average polyp miss-rate of 20% in the colon and thus the subsequent development of a number of post-colonoscopy colorectal cancers. CAD systems might eliminate this variation and lead to more accurate diagnoses. In this editorial, we point out some of the current challenges in the development of efficient computer-based digital assistants. We give examples of proposed tools using various techniques, identify current challenges, and give suggestions for the development and assessment of future CAD systems. | Thomas de Lange Pal Halvorsen Michael Riegler | 2018 | World Journal of Gastroenterology2018，24，45： | 6 |
| 3 | Moment Invariants for Color Constant Image Description显示文摘 | LI Bing XU De LANG Congyan | 2010 | Chinese Journal of Electronics2010，19，2： | 6 |
| 4 | Representation of Integers by Ternary Quadratic Forms | De Lang LI Chun Lai ZHAO Department of Mathematics, Sichuan University, Chengdu 610064, P. R. China Department of Mathematics, Peking University, Beijing 100871, P. R. China | 2001 | Acta Mathematica Sinica,English Series2001，17，4： | 3 |
| 5 | Favorable lifestyle before diagnosis associated with lower risk of screen-detected advanced colorectal neoplasia显示文摘AIM: To investigate the association between adherence to health recommendations and detection of advanced colorectal neoplasia(ACN) in colorectal cancer(CRC) screening.METHODS: A total of 14832 women and men were invited to CRC screening, 6959 in the fecal immunochemical test arm and 7873 in the flexible sigmoidoscopy arm. These were also sent a self-reported lifestyle questionnaire to be completed prior to their first CRC screening. A lifestyle score was created to reflect current adherence to healthy behaviors in regard to smoking, body mass index, physical activity, alcohol consumption and food consumption, and ranged from zero(poorest) to six(best). Odds ratios(ORs) and 95%CIs were calculated using multivariable logistic regression to evaluate the association between the single lifestyle variables and the lifestyle score and the probability of detecting ACN.RESULTS: In all 6315 women and men completed the lifestyle questionnaire, 3323(53%) in the FIT arm and 2992(47%) in the FS arm. This was 89% of those who participated in screening. ACN was diagnosed in 311(5%) participants of which 25(8%) were diagnosed with CRC. For individuals with a lifestyle score of two, three, four, and five-six, the ORs(95%CI) for the probability of ACN detection were 0.82(0.45-1.16), 0.43(0.28-0.73), 0.41(0.23-0.64), and 0.41(0.22-0.73), respectively compared to individuals with a lifestyle score of zero-one. Of the single lifestyle factors, adherence to non-smoking and moderate alcohol intake were associated with a decreased probability of ACN detection compared to being a smoker or having a high alcohol intake 0.53(0.42-0.68) and 0.63(0.43-0.93) respectively.CONCLUSION: Adopted healthy behaviors were inversely associated with the probability of ACN detection. Lifestyle assessment might be useful for risk stratification in CRC screening. | Markus D Knudsen Thomas de Lange Edoardo Botteri Dung-Hong Nguyen Helge Evensen Chloé B Steen Geir Hoff Tomm Bernklev Anette Hjartaker Paula Berstad | 2016 | World Journal of Gastroenterology2016，22，27： | 3 |
| 6 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet . 2012 (9829)2012，，： | 3 |
| 7 | Psychological effects of colorectal cancer screening: Participants vs individuals not invited显示文摘AIM To investigate the possible long-term psychological harm of participating in colorectal cancer(CRC)screening in Norway.METHODS In a prospective, randomized trial, 14294 participants(aged 50-74 years) were invited to either flexible sigmoidoscopy(FS) screening, or a faecal immunochemical test(FIT)(1:1). In total, 4422 screening participants(32%) completed the questionnaire, which consisted of the Hospital Anxiety and Depression Scale and the SF-12, a generic health-related quality of life(HRQOL) measurement, when invited to screening and one year after the invitation. A control group of 7650 individuals was invited to complete the questionnaire only, at baseline and one year after, and 1911(25%) completed the questionnaires.RESULTS Receiving a positive or negative screening result and participating in the two different screening modalities did not cause clinically relevant mean changes in anxiety, depression or HRQOL after one year. FS screening, but not FIT, was associated with an increased probability of being an anxiety case(score ≥ 8) at the one-year follow-up(5.6% of FS participants transitioned from being not anxious to anxious, while 3.0% experienced the reverse). This increase was moderately significantly different from the changes in the control group(in which the corresponding numbers were 4.8% and 4.5%, respectively), P = 0.06. CONCLUSION Most individuals do not experience psychological effects of CRC screening participation after one year, while FS participation is associated with increased anxiety for a smaller group. | Benedicte Kirk?en Paula Berstad Edoardo Botteri Linn Bernklev Badboni El-Safadi Geir Hoff Thomas de Lange Tomm Bernklev | 2016 | World Journal of Gastroenterology2016，22，43： | 2 |
| 8 | Heterogeneous nucleating in the crystallization of polyolefins:Part 2 Kinetics of crystallization of nucleated polyolefins显示文摘 | Binsbergen F L De Lange B G M | 1970 | Polymer1970，11，6： | 2 |
| 9 | 3,5-diiodo- l -thyronine, by modulating mitochondrial functions, reverses hepatic fat accumulation in rats fed a high-fat diet显示文摘 | Maria Pina Mollica Lillà Lionetti Maria Moreno Assunta Lombardi Pieter De Lange Alessandro Antonelli Antonia Lanni Gina Cavaliere Antonio Barletta Fernando Goglia | 2009 | Journal of Hepatology2009，，2： | 2 |
| 10 | Best Practices in Managing Investor Relations Websites: Directions for Future Research显示文摘 | Bollen Laury H Hassink Harold F de Lange Rindert K Buijl Saskia D | 2008 | Journal of Information Systems2008，，2： | 2 |
| 11 | A prospective study on elective umbilical hernia repair in patients with liver cirrhosis and ascites显示文摘 | Hasan H. Eker G.H. van Ramshorst B. de Goede H.W. Tilanus H.J. Metselaar R.A. de Man J.F. Lange G. Kazemier | 2011 | Surgery2011，，3： | 2 |
| 12 | Therapy of organophosphate poisoning in the rat by direct effects of oximes unrelated to ChE-reactivation 显示文摘 | Van Helden HPM De Lange J Busker RW | 1991 | Arch Toxicol1991，65，： | 2 |
| 13 | Recruitment of knee joint ligaments显示文摘 | Blankevoort L Huiskes R De Lange A | 1991 | ASME J Biomech Eng1991，113，1： | 1 |
| 14 | Real ileal protein and amino acid digestibilities in feedsruffs for growing pigs as determined with the 15N-isotope dilution technique显示文摘 | de Lange C F M Souffrant W B Sauer W C | 1990 | J Anim Sci1990，68，： | 1 |
| 15 | Red wine and red wine polyphenolic compounds but not alcohol inhibit ADP-induced platelet aggregation显示文摘 | De Lange DW van Golden PH Scholman WL | 2003 | Eur J Intern Med2003，14，6： | 1 |
| 16 | Senescence induced by altered telomere state, not telomere loss显示文摘 | Karlseder J Smogorzewska A de Lange T | 2002 | Science2002，259，： | 1 |
| 17 | HLAmatchmaker: a molecularly based algorithm for histocompatibility determination. III. Effect of matching at the HLA-A,B amino acid triplet level on kidney transplant survival.显示文摘 | Duquesnoy RJ Takemoto S de Lange P | | 0，，： | 1 |
| 18 | Fuel economy in food-deprived skeletal muscle: signaling pathways and regulatory mechanisms显示文摘 | de Lange P Moreno M Silvestri E | 2007 | FASEB 32007，21，13： | 1 |
| 19 | Genetic correlates of musical pitch recognition inhumans显示文摘 | DRAYNA D MANICHAIKUL A de Lange M | 2001 | Science2001，，291： | 1 |
| 20 | Nd isotopic compositions of eastern Mediterranean sediments: Tracers of the Nile influence during sapropel SI formation? 显示文摘 | Freydier R Michard A de Lange G Thomson J | 2001 | Mar Geol2001，177，12： | 1 |
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