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| 1 | Aquaporins:Their role in cholestatic liver disease显示文摘This review focuses on current knowledge on hepato-cyte aquaporins(AQPs)and their significance in bile formation and cholestasis.Canalicular bile secretion results from a combined interaction of several solute transporters and AQP water channels that facilitate water flow in response to the osmotic gradients created. During choleresis,hepatocytes rapidly increase their canalicular membrane water permeability by modulating the abundance of AQP8.The question was raised as to whether the opposite process,i.e.a decreased canalicular AQP8 expression would contribute to the development of cholestasis.Studies in several experimental models of cholestasis,such as extrahepatic obstructive cholestasis,estrogen-induced cholestasis, and sepsis-induced cholestasis demonstrated that the protein expression of hepatocyte AQP8 was impaired. In addition,biophysical studies in canalicular plasma membranes revealed decreased water permeability associated with AQP8 protein downregulation.The combined alteration in hepatocyte solute transporters and AQP8 would hamper the efficient coupling of osmotic gradients and canalicular water flow.Thus cholestasis may result from a mutual occurrence of impaired solute transport and decreased water permeability. | Guillermo L Lehmann Maria C Larocca Leandro R Soria Raúl A Marinelli | 2008 | World Journal of Gastroenterology2008，14，46： | 8 |
| 2 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 3 | Parameters of a severe disease course in ulcerative colitis显示文摘AIM:To detect high risk patients with a progressive disease course of ulcerative colitis(UC) requiring immunosuppressive therapy(IT).METHODS:A retrospective,multicenter analysis of 262 UC patients from eight German tertiary inflammatory bowel disease centres was performed.Patients were divided into two groups depending on the patients need to initiate immunosuppressive therapy in the disease course.A comparison between the two groups was made with regard to demographics,clinical and laboratory parameters obtained within three months after UC diagnosis and the response to first medical therapy.Using this data,a prognostic model was established to predict the individual patients probability of requiring an immunosuppressive therapy.RESULTS:In 104(39.7%) out of 262 patients,UC therapy required an immunosuppressive treatment.Patients in this group were significantly younger at time of diagnosis(HR = 0.981 ± 0.014 per year,P = 0.009),and required significantly more often a hospitalisation(HR = 2.5 ± 1.0,P < 0.001) and a systemic corticosteroid therapy at disease onset(HR = 2.4 ± 0.8,P < 0.001),respectively.Response to steroid treatment was significantly different between the two groups of patients(HR = 5.2 ± 3.9 to 50.8 ± 35.6 compared to no steroids,P = 0.016 to P < 0.001).Furthermore,in the IT group an extended disease(HR = 3.5 ± 2.4 to 6.1 ± 4.0 compared to proctitis,P = 0.007 to P = 0.001),anemia(HR = 2.2 ± 0.8,P < 0.001),thrombocytosis(HR = 1.9 ± 1.8,P = 0.009),elevated C-reactive protein(CRP)(HR = 2.1 ± 0.9,P < 0.001),and extraintestinal manifestations in the course of disease(HR = 2.6 ± 1.1,P = 0.004) were observed.Six simple clinical items were used to establish a prognostic model to predict the individual risk requiring an IT.This probability ranges from less than 2% up to 100% after 5 years.Using this,the necessity of an immunosuppressive therapy can be predicted in 60% of patients.Our model can determine the need for an immunosuppressive drug therapy or if a 'watch and wait' approach is reasonable already early in the treatment course of UC.CONCLUSION:Using six simple clinical parameters,we can estimate the patients individual risk of developing a progressive disease course. | Andreas Stallmach Luisa Nickel Thomas Lehmann Bernd Bokemeyer Martin Bürger Dietrich Hüppe Wolfgang Kruis Susanna Nikolaus Jan C Preiss Andreas Sturm Niels Teich Carsten Schmidt | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 4 | Vitamins as hormones显示文摘 | Reichrath J Lehmann B Carlberg C | 2007 | Hormone and Metabolic Research2007，39，2： | 1 |
| 5 | Survey: Interpolation methods in medical image processing 显示文摘 | LEHMANN T M GONNER C SPITZER K | 1999 | IEEE Transactions on Medical Imaging1999，18，11： | 1 |
| 6 | Autonomic imbalance hypothesis and overtraining syndrome 显示文摘 | Lehmann M Foster C Dickhuth H H | 1998 | Med Sci Sports Exercise1998，30，7： | 1 |
| 7 | Effect of hysteresis on water flow in a sand column with a fluctuating capillary fringe显示文摘 | Lehmann P Stauffer F Hinz C | 1998 | Journal of Contaminant Hydrology1998，33，： | 1 |
| 8 | Science显示文摘 | Wanke M C Lehmann O | 1997 | (275):12841997，，275： | 1 |
| 9 | Generation of phase-controlled ultraviolet pulses and characterization by a simple autocorrelator setup 显示文摘 | MOHRING J BUCKUP T LEHMANN C S | 2009 | J Opt Soc Am B2009，26，8： | 1 |
| 10 | Vitamins as hor- mones 显示文摘 | Reichrath J Lehmann B Carlberg C | 2007 | Horm Met Res2007，39，2： | 1 |
| 11 | Biochar effects on soil biota-A review显示文摘 | Lehmann J Riuig M C Thies J | 2011 | Soil Biology and Biochemistry2011，43，9： | 1 |
| 12 | Nutri- ent availability and leaching in an archaeological anthrosol and a Ferralsol of the Central Amazon basin: Fertilizer, manure and charcoal amendments显示文摘 | LEHMANN J DA SILVA JR J P STEINER C | 2003 | Plant and Soil2003，249，2： | 1 |
| 13 | Long term effects of manure, charcoal and mineral fertilization on crop production and fertility on a highly weathered Central Amazonian upland soil显示文摘 | Steiner C Teixeira W G Lehmann J | 2007 | Plant and Soil2007，291，： | 1 |
| 14 | Survey:interpolation methods in medical image processing显示文摘 | Gonner C Spitzer K | 1999 | IEEE Trans Med Image1999，18，11： | 1 |
| 15 | Addendum: B- spline interpolation in medical image processing 显示文摘 | Lehmann T M Conner C Spitzer K | 2001 | IEEE Transactions on Medical Imaging2001，20，7： | 1 |
| 16 | Plasma exchange in neuroimmunological disorders:Part 1:Rationale and treatment of inflammatory central nervous system disorders显示文摘 | Lehmann H C Hartung H P Hetzel G R | 2006 | Arch Neurol2006，63，7： | 1 |
| 17 | Long term effects of ma- nure, charcoal and mineral fertilization on crop production and fertility on a highly weathered central Amazonian upland soil 显示文摘 | Steiner C Teixeira W G Lehmann J | 2007 | Plant and Soil2007，291，： | 1 |
| 18 | Long term effects of manure, charcoal and mineral fertilization on crop production and fertility on a highly weathered Central Amazonian upland soil 显示文摘 | Steincr C Teixeira W G Lehmann J | 2007 | Plant and Soil2007，291，： | 1 |
| 19 | Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization显示文摘 | Heeschen C Aicher A Lehmann R | 2003 | Blood2003，102，： | 1 |
| 20 | Differential mucin MUC7 gene expression in invasive bladder carcinoma in contrast to uniform MUC1 and MUC2 gene expression in both normal urothelium and bladder carcinoma显示文摘 | Retz M Lehmann J Roder C | 1998 | Cancer Res1998，58，24： | 1 |
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