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| 1 | Modern management of anal fistula显示文摘Ideal surgical treatment for anal fistula should aim to eradicate sepsis and promote healing of the tract,whilst preserving the sphincters and the mechanism of continence.For the simple and most distal fistulae,conventional surgical options such as laying open of the fistula tract seem to be relatively safe and therefore,well accepted in clinical practise.However,for the more complex fistulae where a significant proportion of the anal sphincter is involved,great concern remains about damaging the sphincter and subsequent poor functional outcome,which is quite inevitable following conventional surgical treatment.For this reason,over the last twodecades,many sphincter-preserving procedures for the treatment of anal fistula have been introduced with the common goal of minimising the injury to the anal sphincters and preserving optimal function.Among them,the ligation of intersphincteric fistula tract procedure appears to be safe and effective and may be routinely considered for complex anal fistula.Another technique,the anal fistula plug,derived from porcine small intestinal submucosa,is safe but modestly effective in long-term follow-up,with success rates varying from 24%-88%.The failure rate may be due to its extrusion from the fistula tract.To obviate that,a new designed plug(GORE BioA ) was introduced,but long term data regarding its efficacy are scant.Fibrin glue showed poor and variable healing rate(14%-74%).Fi La C and video-assisted anal fistula treatment procedures,respectively using laser and electrode energy,are expensive and yet to be thoroughly assessed in clinical practise.Recently,a therapy using autologous adiposederived stem cells has been described.Their properties of regenerating tissues and suppressing inflammatory response must be better investigated on anal fistulae,and studies remain in progress.The aim of this present article is to review the pertinent literature,describing the advantages and limitations of new sphincterpreserving techniques. | Elsa Limura Pasquale Giordano | 2015 | World Journal of Gastroenterology2015，21，1： | 59 |
| 2 | A novel potent vasoconstrictor petide produced by vascular endothelial cell显示文摘 | YANAGISAWA M KURIHARA H LIMURA S | 1998 | Nature1998，332，： | 1 |
| 3 | Efficacy and mode of action of manidipine : A new calcium antagonist显示文摘 | Limura O Shlmamoto K | 1993 | Am Heart J1993，125，： | 1 |
| 4 | Expression of LL- 37 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pylor 显示文摘 | Hase K Murakami M limura M | 2003 | Gastroenterology2003，125，6： | 1 |
| 5 | Effect of ureteral obstruction on matrix metalloproteinase-2 in rat renal cortex 显示文摘 | limura O Takahashi H Yashiro T | 2004 | Clin Exp Nephrol2004，8，3： | 1 |
| 6 | Effect of lipid-lowering strategies on tubular cell biology显示文摘 | Vrtovsnik F Essig M Limura O | 1999 | Kidney lnt1999，56，71： | 1 |
| 7 | Cytokine profile in colonic mucosa ulcerative colitis correlates with disease activity and response to granulocytapheresis显示文摘 | Tsukada Y Nakamura T limura M | 2002 | Am J Gast roenterol2002，97，11： | 1 |
| 8 | Blunted para-sympa - thetic modulation in salt - sensitive patients with essential hypertension evaluation by power - spectral analysis of heart - rate varia - bility 显示文摘 | Onoyama K Omae T Limura O | 1987 | Current Therapeutic Resarch1987，42，： | 1 |
| 9 | Modem management of anal fistula显示文摘 | Limura E Giordano P | 2015 | World J Gastroenterol2015，21，： | 1 |
| 10 | Syn- thesis of continuous silicon carbide fiber with high tensile strength and high Young's modulus 显示文摘 | Yajima S Hasegawa Y Hayashi J Limura M | 1978 | Journal of Ma- terials Science1978，13，： | 1 |
| 11 | Blunted para-sympathetic mod ulation in saltsensitive patients with essential hypertension evalua tion by power- spectral analysis of heartrate variability显示文摘 | noyama K Omae T Limura O | 1987 | Current Therapeutic Research1987，42，6： | 1 |
| 12 | Simplified mechanical model for evaluatingstress in pipeline subject to settlement显示文摘 | Limura S | 2004 | Construc-tion and Building Materials2004，18，6： | 1 |
| 13 | High - strength a luminum alloys containing nanoquasicrystalline paticles 显示文摘 | Akihisa Inoune Hisamichi Limura | 2000 | Materials Science and Engineering2000，，286： | 1 |
| 14 | Electromagnetic wave absorption properties of carbonyl iron-ferrite/PMMA composites fabricated by hybridization method显示文摘 | Kato T Hyodo T | 2007 | Journal of Magnetism and Magnetic Materials2007，312，1： | 1 |
| 15 | Simplified mechanical model for evaluating stress in pipeline subjected to settlement显示文摘 | LIMURA S | 2004 | Construction and Build- ing Materials2004，18，： | 1 |
| 16 | Simplified mechanical model for evaluating stress in pipeline subject to settlement显示文摘 | LIMURA S | 2004 | Construction and Building Materials2004，18，6： | 1 |
| 17 | Low-intensity fetal lungs on MRI may suggest the diagnosis of pulmonary hypoplasia显示文摘 | Kuwashima S Nishimura G limura F | 2001 | Pediatr Radiol2001，31，9： | 1 |
| 18 | (Delphinidin 3-gentiobiosyl)(apigenin 7-glucosyl)malonate from the flowers of Eichhorniacrassipes显示文摘 | Kenjiro Toki Norio Saito Ken limura | 1994 | Phytochemistry1994，36，5： | 1 |
| 19 | Infarct size limitation by preconditioning:its phenomeno logical features and the key role of adenosine 显示文摘 | Miura T Limura O | 1993 | Cardiovase Rec1993，27，1： | 1 |
| 20 | 显示文摘 | Oyama T Limura Y Takeuchi K | 1996 | Mater Sci Lett1996，15，： | 1 |
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