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| 1 | Release of interleukin-10 and neurotrophic factors in the choroid plexus:possible inductors of neurogenesis following copolymer-1 immunization after cerebral ischemia显示文摘Copolymer-1(Cop-1) is a peptide with immunomodulatory properties, approved by the Food and Drug Administration of United States in the treatment of multiple sclerosis. Cop-1 has been shown to exert neuroprotective effects and induce neurogenesis in cerebral ischemia models. Nevertheless, the mechanism involved in the neurogenic action of this compound remains unknown. The choroid plexus(CP) is a network of cells that constitute the interphase between the immune and central nervous systems, with the ability to mediate neurogenesis through the release of cytokines and growth factors. Therefore, the CP could play a role in Cop-1-induced neurogenesis. In order to determine the participation of the CP in the induction of neurogenesis after Cop-1 immunization, we evaluated the gene expression of various growth factors(brain-derived neurotrophic factor, insulin-like growth factor 1, neurotrophin-3) and cytokines(tumor necrosis factor alpha, interferon-gamma, interleukin-4(IL-4), IL-10 and IL-17), in the CP at 14 days after ischemia. Furthermore, we analyzed the correlation between the expression of these genes and neurogenesis. Our results showed that Cop-1 was capable of stimulating an upregulation in the expression of the genes encoding for brain-derived neurotrophic factor, insulin-like growth factor 1, neurotrophin-3 and IL-10 in the CP, which correlated with an increase in neurogenesis in the subventricular and subgranular zone. As well, we observed a downregulation of IL-17 gene expression. This study demonstrates the effect of Cop-1 on the expression of growth factors and IL-10 in the CP, in the same way, presents a possible mechanism involved in the neurogenic effect of Cop-1. | Yolanda Cruz Edna E.García Jessica V.Gálvez Stella V.Arias-Santiago Horacio G.Carvajal Raúl Silva-García Herlinda Bonilla-Jaime Julio Rojas-Castaneda Antonio Ibarra | 2018 | Neural Regeneration Research2018，13，10： | 7 |
| 2 | Suitability of aqueous chlorine dioxide versus sodium hypochlorite as an effective sanitizer for preserving quality of fresh-cut lettuce while avoiding by-product formation显示文摘 | Francisco López-Gálvez Ana Allende Pilar Truchado Ascensión Martínez-Sánchez Juan A. Tudela María V. Selma María I. Gil | 2009 | Postharvest Biology and Technology2009，，1： | 2 |
| 3 | Characterization and kinetic study of carbon-based briquettes for the reduction of NO 显示文摘 | Boyano A Ga'lvez M E La'zaro M J | 2006 | Carbon2006，44，： | 1 |
| 4 | Comparative study on redox properties and catalytic behavior for CO oxidation of CuO/CeO2 and CuO/ZrCeO4 catalysts 显示文摘 | Martinez-Arias A Fernández-Garcia M Gálvez O | 2000 | J Catal2000，195，： | 1 |
| 5 | Carbon- based catalytic briquettes for the reduction of NO: Effect of H2SO4 and HNO3 carbon support treatment 显示文摘 | Boyano A Ga'lvez M E Moliner R | 2008 | Fuel2008，，87： | 1 |
| 6 | Dietary olive oil supplemented with fish oil,rich in EPA and DHA(n-3) polyunsaturated fatty acids,attenuates colonic inflammation in rats with DSS-induced colitis显示文摘 | Camuesco D Gálvez J Nieto A | 2005 | Biochemical and Molecular Actions of Nutrients2005，135，4： | 1 |
| 7 | An analytical model approach to heap leaching显示文摘 | MELLADO M E CISTERNAS L A GáLVEZ E D | 2009 | Hydrometallurgy2009，95，12： | 1 |
| 8 | A new high-intensity ultrasonic technology for food dehydration显示文摘 | GALLEGO-JUREZ J A RODRGUEZ G GLVEZ J C | 1999 | Drying Technology1999，17，3： | 1 |
| 9 | Bacteriocin based strategies for food biopreservation显示文摘 | Gálvez A Hikmate A Lucas L R | | 0，，1： | 1 |
| 10 | Comparative study on redox properties and catalytic behavior for CO oxidation of CuO/CeO2 and CuO/ZrCeO4 catalysts显示文摘 | Fernández-García M Gálvez O | 2000 | J Catal2000，195，1： | 1 |
| 11 | A discrete crack approach to normal/shear cracking of concrete显示文摘 | ?ervenka J Cendónc D A Saouma V | 2002 | Cement and Concrete Research2002，32，： | 1 |
| 12 | Antihypertensive Effects of Peroxisome Proliferator-Activated Receptor-β Activation in Spontaneously Hypertensive Rats显示文摘 | María José Zarzuelo Rosario Jiménez Pilar Galindo Manuel Sánchez Ana Nieto Miguel Romero Ana María Quintela Rocío López-Sepúlveda Manuel Gómez-Guzmán Elvira Bailón Isabel Rodríguez-Gómez Antonio Zarzuelo Julio Gálvez Juan Tamargo Francisco Pérez-Vizcaíno | 2011 | Hypertension2011，，4： | 1 |
| 13 | Dynamic fracture toughness of a high strength armor steel显示文摘 | F. Gálvez D. Cendón N. García A. Enfedaque V. Sánchez-Gálvez | 2009 | Engineering Failure Analysis2009，，8： | 1 |
| 14 | Dietary olive oil supple- mented with fish oil, rich in EPA and DHA (n-3) polyunsaturated fatty acids, attenuates colonic inflammation in rats with DSS-in- ducedcolitis显示文摘 | Camueseo D G 6 lvez J Nieto A | 2005 | JNutr2005，135，4： | 1 |
| 15 | Linguistic adaptation into Spanish and psychometric validation of the ID-Pain questionnaire for the screening of neuropathic pain显示文摘 | Gálvez R Pardo A Cerón JM | 2008 | Med Clin(Barc)2008，131，15： | 1 |
| 16 | Nutrition facts and functional potential of quinoa(Chenopodium quinoa Willd)an ancient Andean grain:a review显示文摘 | Vega-Gálvez A Miranda M Vergara J | 2010 | Journal of the Science of Food and Agriculture2010，90，15： | 1 |
| 17 | Landfill leachate treatment with microbial fuel cells:scale-up through plurality显示文摘 | Gálvez A Greenman J Ieropoulos I | | 0，，21： | 1 |
| 18 | Orientation-and concentration-dependent surfactant adsorption on silicon in aqueous alkaline solutions:explaining the changes in the etch rate,roughness and undercutting for MEMS applications显示文摘 | GOS(A)LVEZ M A TANG B PAL P | | 0，，12： | 1 |
| 19 | Development and validation of extraction methods for determination of zinc and arsenic speciation in soils using focused ultrasound Application to heavy metal study in mud and soils显示文摘 | A López-Gonzálvez C Barbas | 2001 | Analytical Chemical Acta2001，，442： | 1 |
| 20 | Plant NHX cation/proton antiporters显示文摘 | RODRIGUEZ-ROSALES M P G(A)LVEZ E J Huertas R | 2009 | Plant Signal Behav2009，4，4： | 1 |
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