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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | Adeno-associated virus vector-mediated gene transfer to somatic cells in the central nervous system显示文摘 | Mandel RJ Muzyczka N | 2000 | Adv Virus Res2000，55，： | 1 |
| 3 | Neuropathy and cognitive impairment following vaccination with the OspA protein of Borrelia burgdorferi显示文摘 | Latov N Wu AT Chin RL | 2004 | J Peripher Nerv Syst2004，9，3： | 1 |
| 4 | Photosynthetic light environments in a lowland tropical rain forest in Costa Rica 显示文摘 | Chazdon RL Fetcher N | 1984 | J Ecol1984，72，： | 1 |
| 5 | MMP-9 secretion and MMP-2 activation distinguish invasive and metastatic sublines of a mouse mammary carcinoma system showing epithelial mesenchymal transition traits显示文摘 | Tester AM Ruangpani N Anderso RL | 2000 | Clin Exp Metastasis2000，18，7： | 1 |
| 6 | The outcomes of elective laparoscopic and open cholecystectomies显示文摘 | Kane RL Lurie N Borbas C | 1995 | J Am Coil Surg1995，180，2： | 1 |
| 7 | Parental identification of carly behavioral abnormalities in children with autistic disorder显示文摘 | Young RL Brewer N Pattison C | 2003 | Autism2003，7，2： | 1 |
| 8 | Colorectal cancer: a model for epigenetic tumorigenesis显示文摘 | Wong JJ Hawkins N J Ward RL | 2007 | Gut2007，56，1： | 1 |
| 9 | The leading cause of gastroen- teritis worldwide 显示文摘 | Koo HL Ajami N Atmar RL | 2010 | Discovery Medicine2010，10，： | 1 |
| 10 | Oncologic out- comes after laparoscopic partial nephrectomy: mid-term results 显示文摘 | Favaretto RL Sanchez-Salas R Benoist N | 2013 | J Endourol2013，27，： | 1 |
| 11 | Otto Fritz Meyerhof and the elucidation of the glycolytic pathway显示文摘 | Kresge N Simoni RD Hill RL | 2005 | J Biol Chem2005，280，4： | 1 |
| 12 | Anti-ICAM-1 antibody reduces ischemie cell damage after transient middle cerebral artery occlusion in the rat显示文摘 | Zhang RL Chopp M Jiang N | 1994 | Neurology1994，44，9： | 1 |
| 13 | Evaluation of tumor angiogenesis measured with microvessel density (MVD) as a prognostic indicator in nasopharyngeal carcinoma:results of RTOG 9505显示文摘 | Foote RL Weidner N Harris J | 2005 | Int J Radiat Oncol Biol Phys2005，61，3： | 1 |
| 14 | Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens:comparison of wild-type and variant COMT isoforms显示文摘 | Dawling S Roodi N Mernaugh RL | 2001 | Cancer Res2001，61，18： | 1 |
| 15 | Nurse staffing and patient falls on acute care hospital units 显示文摘 | Dunton N Gajewski B Taunton RL | 2004 | Nurs Outlook2004，52，1： | 1 |
| 16 | The Prevalence and num- ber of people with retinal vein occlusion:Pooled data from popula- tion based studies from the US,Europe, Asia and Australia显示文摘 | Rogers S Mclntosh RL Cheung N | 2010 | Oph- thalmol2010，117，2： | 1 |
| 17 | Evaluation of tumor angiogenesis measured with microvessel density(MVD)as a prognostic indicator in nasopharyngeal carcinoma:results of RTOG 9505显示文摘 | Foote RL Weidner N Harris J | 2005 | Int J Radiat Oncol Biol Phys2005，61，3： | 1 |
| 18 | A new autosomal recessive form of Stickler syndrome is caused by a mutation in the COL9A1 gene 显示文摘 | Van Camp G Snoeckx RL Hilgert N van den Ende J Fukuoka H Wagatsuma M | 2006 | Am J Hum Genet2006，79，3： | 1 |
| 19 | N-of-1 trials of expen- sive biological therapies: a third way? 显示文摘 | Kravitz RL Duan N White RH | 2008 | Arch Intern Med2008，168，10： | 1 |
| 20 | Variations of dose and electrode spacing for rat breast Cancer electrochemical treatment显示文摘 | Ren RL Vora N Yang F | 2001 | Bioelectromagnetics2001，22，： | 1 |
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