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| 1 | Predictive Values of Body Mass Index and Waist Circumference for Risk Factors of Certain Related Diseases in Chinese Adults - Study on Optimal Cut-off Points of Body Mass Index and Waist Circumference in Chinese Adults显示文摘Objective For prevention of obesity in Chinese population, it is necessary to definethe optimal range of healthy weight and the appropriate cut-off points of BMI and waistcircumference for Chinese adults. The Working Group on Obesity in China under the supportof International Life Sciences Institute Focal Point in China organized a meta-analysis on therelation between BMI, waist circumference and risk factors of related chronic diseases (e. g.,high diabetes, diabetes mellitus, and lipoprotein disorders). Methods 13 population studiesin all met the criteria for enrollment, with data of 239 972 adults (20-70 year) surveyed inthe 1990s. Data on waist circumference was available for 111411 persons and data on serumlipids and glucose were available for more than 80 000. The study populations located in21provinces, municipalities and autonomous regions in China's Mainland as well as inTaiwan. Each enrolled study provided data according to a common protocol and uniformformat. The Center for data management in Department of Epidemiology, Fu Wai Hospitalwas responsible for statistical analysis. Results and conclusion The prevalence ofhypertension, diabetes, dyslipidemia and clustering of risk factors all increased withincreasing levels of BMI or waist circumference. BMI at 24 with best sensitivity andspecificity for identification of the risk factors, was recommended as the cut-off point foroverweight, BMI at 28 which may identify the risk factors with specificity around 90 % wasrecommended as the cut-off point for obesity. Waist circumference beyond 85 cm for menand beyond 80 cm for women were recommended as the cut-off points for central obesity.Analysis of population attributable risk percent illustrated that reducing BMI to normalrange (<24) could prevent 45%-50% clustering of risk factors. Treatment of obese persons(BMI≥28)with drugs could prevent 15%-17% clustering of risk factors. The waistcircumference controlled under 85 cm for men and under 80 cm for women, could prevent47%-58% clustering of risk factors. According to these, a classification of overweight andobesity for Chinese adults is recommended. | ZHOU BEI-FAN2Cooperative Meta-Analysis Group of the Working Group on Obesity in China | 2002 | Biomedical and Environmental Sciences2002，15，1： | 237 |
| 2 | Report on Childhood Obesity in China (1) Body Mass Index Reference for Screening Overweight and Obesity in Chinese School-age Children显示文摘Purpose To establish and propose a national body mass index (BMI) reference for screening overweight and obesity in Chinese school-age children and adolescents. Methods 2000 CNSSCH (Chinese National Survey on Students Constitution and Health) data, including 216 620 primary and secondary school students aged 7 to 18 years old, were used as a reference population. Compared with those of the NCHS internatioanl reference, three temporary sets of cut-off BMI were proposed by testing different combinations of P8s, P9o, and P95. When physiological and biochemical measures between and among 'obesity','overweight', and 'normal weight' groups were taken into consideration, set Ⅱ was selected to be the most appropriate one.The sex-age-specific curves were then plotted and smoothed by using B-spline method. Results Based on the samples from costal developed metropolis, the BMI curves successfully overcame the shortcomings of lower and level-off tendency of the Chinese total population. Temporary set Ⅱ, composed by cut-offs of P85 for overweight and P95 for obesity, was finally selected by its sensitivity and peculiarity. BMI 24 and 28 were used as cut-offs for overweight and obesity for both males and females aged 18 years old. These cut-offs, consistent with Chinese Adult's Reference, was proposed as the Body mass index reference for screening overweight and obesity in Chinese school-age children and adolescents. Conclusion The new reference clearly showed its superiorty in both prospectivity and actuality. The proposed reference minimized the gaps of the BMI curve between Chinese adolescents and the international reference. Most importantly was that it was consistent with the Eastern Asia ethnic characteristics of body fatness growth. It was therefore proposed by the Working Group on Obesity in China (WGOC) to use it as an nationwide reference for screening overweight and obesity of school-age children and adolescents in China. | COOPERATIVE STUDY ON CHILDHOOD OBESITY WORKING GROUP ON OBESITY IN CHINA (WGOC) | 2005 | Biomedical and Environmental Sciences2005，18，6： | 57 |
| 3 | Effect of Body Mass Index on All-cause Mortality and Incidence of Cardiovascular Diseases─Report for Meta-Analysis of Prospective Studies on Optimal Cut-off Points of Body Mass Index in Chinese Adults显示文摘Objective To verify the optimal cut-off points for overweight and obesity in Chinese adults based on the relationship of baseline body mass index (BMI) to all-cause mortality, and incidence of cardiovascular diseases from pooled data of Chinese cohorts. Methods The prospective study data of existing cohort studies in China were collected, and the age-adjusted all-cause mortality stratified by BMI were estimated. The similar analysis was repeated after excluding deaths within the first three years of follow-up and after excluding smokers. The incidence of age-adjusted coronary heart disease (CHD) and stroke stratified by BMI were also analyzed. Multiple Cox regression coefficients of BMI for the incidence of CHD and stroke after controlling other risk factors were pooled utilizing the methods of weighting by inverse of variance to reveal whether BMI had independent effect and its strength on the incidence of CHD and stroke. Results The data of 4 cohorts including 76 227 persons, with 745 346 person-years of follow-up were collected and analyzed. The age-adjusted all-cause mortality stratified by BMI showed a U-shaped curve, even after excluding deaths within the first three years of follow-up and excluding smokers. Age-adjusted all-cause mortality increased when BMI was lower than 18.5 and higher than 28. The incidence of CHD and stroke, especially ishemic stroke increased with increasing BMI, this was consistent with parallel increasing of risk factors. Cox regression analysis showed that BMI was an independent risk factor for both CHD and stroke. Each amount of 2 kg/m2 increase in baseline BMI might cause 15.4%, 6.1% and 18.8 % increase in relative risk of CHD, total stroke and ischemic stroke. Reduction of BMI to under 24 might prevent the incidence of CHD by 11% and that of stroke by 15 % for men, and 22 % of both diseases for women. Conclusion BMI ≤18.5, 24-27.9 and ≥28 (kg/m2) is the appropriate cut-off points for underweight, overweight and obesity in Chinese adults. | ZHOU BEI-FAN Cooperative Meta-Analysis Group of the Working Group on Obesity in China* | 2002 | Biomedical and Environmental Sciences2002，15，3： | 58 |
| 4 | Empirical Changes in the Prevalence of Overweight and Obesity among Chinese Students from 1985 to 2010 and Corresponding Preventive Strategies显示文摘Objective To determine the extent of the obesity epidemic in school‐aged Chinese children in 2010 and track the increasing trend in different socioeconomic regions over the preceding 25 years. Strategies for preventing childhood obesity are suggested. Methods We used a dataset provided by the Chinese National Survey on Students' Constitution and Health from 1985‐2010. Subjects were 7‐18‐year‐old students randomly selected from urban and rural areas in 30 provinces. Eight subgroups were created according to region and socioeconomic status. Results Increased rates of the epidemic (overweight and obesity combined) were greatest in large coastal cities‐32.6% and 19.1% among males and females, respectively. These rates has neared that of developed countries. Similar increases were found in all other regions, including the once poverty‐stricken rural west. The epidemic in most of the rural areas began after 2000, but has spread swiftly over the last decade. In 2010, it was estimated that 9.9% of Chinese school‐aged children and adolescents were overweight and that an additional 5.1% were obese, representing an estimated 30.43 million individuals. Conclusion The prognosis for China's childhood‐obesity epidemic is dire. To prevent childhood obesity, we suggest several strategies, including reasonable dietary intake, increase physical activity, a change in sedentary lifestyles and corresponding behavioral modifications. | JI Cheng Ye CHEN Tian Jiao Working Group on Obesity in China (WGOC) | 2013 | Biomedical and Environmental Sciences2013，26，1： | 49 |
| 5 | Guidelines for prevention and control of overweight and obesity in Chinese adults显示文摘 | Cooperative Group of China Obesity Task Force | 2004 | Acta Nutri Sinica2004，26，1： | 1 |
| 6 | National Institutes of Health显示文摘 | Clinical guidelines on the identification evaluation and treatment of overweight and obesity in adults: the evidence report | 1998 | Obes Res1998，62，： | 1 |
| 7 | Am J显示文摘 | Galdwell SH Hespenheide EE Subacute liver failure in obese women | 2002 | Gastroenterol2002，97，： | 1 |
| 8 | And the risk of kidney stones显示文摘 | Taylor EN Stampfer MJ Obesity CG | 2005 | JAMA2005，293，4： | 1 |
| 9 | The impact of cortisol inhibition by etomidate显示文摘 | Saranteas T Voukena V Zotos N Lipid kinetics in obese patients undergoing laparoscopy | 2004 | Eur J Drag Metab Phamcokinet2004，29，3： | 1 |
| 10 | Association with increased insulin binding and cell-surface GLUT4 as measured by photoaffinity labeling显示文摘 | Young PW Cawthorne MA Coyle PJ Repeat treatment of obese mice with BRL 49653 a new potent insulin sensitizer enhances insulin action in white adipocytes | 1995 | Diabetes1995，44，9： | 1 |
| 11 | NIH consensus development conference显示文摘 | Gastrointestinal Surgery for severe obesity | 1996 | Nutrition1996，12，： | 1 |
| 12 | Overweight,obesity,and health risk显示文摘 | National Task Force on the Prevention and Treatment of Obesity | 2000 | Arch Intern Med2000，160，7： | 1 |
| 13 | Consensus devel- opment conference on antipsychotic drugs and obesity and diabe- tes显示文摘 | American Diabetes Association American Psychiatric Associa- tion American Association of Clinical Endocrinologists North American Association for the Study of Obesity | 2004 | J Clin Psychiatry2004，65，2： | 1 |
| 14 | The guildelines for prevention and control of overweight and obesity in Chinese adults显示文摘 | Working Group on Obesity in China Department of Disease Control Ministry of Health | | 0，，01： | 1 |
| 15 | Aneutralizing glomerular hypertrophyina model of zucker diabetic fatty rat显示文摘 | Schrijvers BF Flyvhjerg VEGF antibody prevents obese type2 diabetes the Dial transplant 2006 21 A Tilton RG | 2006 | Nephrol2006，，2： | 1 |
| 16 | The guidelines for preventing and control of overweight and obesity in Chinese adult 显示文摘 | Working Group on Obesity in China | 2004 | Acta Nutrimenta Sinica2004，26，： | 1 |
| 17 | Predictive values of body mass index and waist circumference to risk factors of related diseases in Chinese adult population显示文摘 | Coorperative Meta-Analysis Group of China Obesity Task Force | 2002 | Chin J Epidemiol2002，23，1： | 1 |
| 18 | Predictive values of body mass index and waist circumference to risk factors of related diseases in Chinese adult population显示文摘 | Coorperative Meta-analysis Group of China Obesity Task Force | 2002 | Chin J Epidemiol2002，23，1： | 1 |
| 19 | Childhood Report 显示文摘 | International Obesity Task Force | 2004 | IASO News- letter2004，，6： | 1 |
| 20 | Silfen ME, Denburg MR, Manibo AM, Lobe RA, Jaffe R, Fefin M, Levlne LS, Oberfield SE 显示文摘 | Early endocrine metabolic and sonographic characteristics of polycystic ovary syndrome (PCOS): comparison between nonobese and obese adolescents | 2003 | J Ciin Endoerinol Metab2003，88，10： | 1 |
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