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| 1 | Function of apoptosis and expression of the proteins Bcl-2,p53 and C-myc in the development of gastric cancer显示文摘INTRODUCTIONIn China ,the incidence and mortality of gastric cancer rank the second among all cancers. Recent development of cancer [1-20].The aim of this study was investigat the insight of apoptosis and bcl-2, p53 and C-myc protein expression in the development of gastric cancer . | An Gao Xu Shao Guang Li Ji Hong Liu Ai Hua Gan Research Laboratory of Digestive Disease,Huizhou Central People’s Hospital,Huizhou 516001,Guangdong Province,ChinaDr.An Gao Xu graduated from Guangdong Medical College in 1984.He is an associate physician-in-chief,specializing in the research and treatment of gastrointestinal and liver tumors.He has published 24 papers and 1 book. | 2001 | World Journal of Gastroenterology2001，7，3： | 91 |
| 2 | 甘肃永靖大何庄遗址发掘报告显示文摘永靖县属甘肃省临夏回族自治州。县境四周环山,地势窄长,黄河横贯其中。县境的两端都是峡谷,西端为寺沟峡,著名的炳灵寺石窟就在这里,东北即刘家峡。在两峡谷的中间地带是河谷平原,形成了一个长条形的永靖盆地。在旧县治莲花城的东南有蜿蜒北流的大夏河,至城东约200米处与黄河汇合。沿着黄河及其支流大夏河的两岸,有发育很好的黄土台地,上面分布着许多不同性质的古文化遗址。 | The Kansu Archaeological Team of IAAS | 1974 | 考古学报1974，，2： | 99 |
| 3 | 山西芮城东庄村和西王村遗址的发掘显示文摘芮城县在山西省的最南边,县的北部多山地和坡地,县的南部是宽度不等的狭长平地。这次发掘的东庄村和西王村两个地点,就在这一狭长平地的南缘,东庄村在东,西王村在西,两村相距约22公里(图一)。这20多公里的地带原属永济县,1958年划归芮城县。东庄村遗址于1955年冬发现,1958年5、6月发掘。西王村遗址于1960年春发现,同年5—7月发掘。两个遗址的发掘资料均以仰韶文化为主,其次是龙山文化和两周的遗存,周以后的零星资料未载入本报告中。 | The Shansi Archaeological Team,Institute of Archaeology,Academic Sinica | 1973 | 考古学报1973，，1： | 82 |
| 4 | 中国5岁以下儿童死亡抽样调查显示文摘中国5岁以下儿童死亡抽样调查结果表明:1991年全国新生儿、婴儿、5岁以下儿童死亡率分别为33.07‰、50.19‰、61.03‰;城市分别为12.52‰、17.31‰、20.86‰;农村分别为37.90‰、58.02‰、71.08‰。农村占全国5岁以下儿童死亡的93.30%。婴儿死亡占5岁以下儿童死亡的80.20%,新生儿死亡占婴儿死亡的64.80%。提示5岁以下儿童死亡的前四位分类死因为新生儿疾病、呼吸系统疾病、意外事故及先天畸形;前四位疾病是肺炎、新生儿窒息、早产、腹泻。 | (The Nuitonul CollaborativeGroup for Survey of Dealhs of Under 5 ChJ7dren, Beijing100020.) | 1994 | 中华儿科杂志1994，32，3： | 111 |
| 5 | 非酒精性脂肪性肝病诊疗指南显示文摘非酒精性脂肪性肝病(NAFLD)是指除外酒精和其他明确的损肝因素所致的,以弥漫性肝细胞大泡性脂肪变为主要特征的临床病理综合征,包括单纯性脂肪肝以及由其演变的脂肪性肝炎(NASH)和肝硬化,胰岛素抵抗和遗传易感性与其发病关系密切。随着肥胖和糖尿病的发病率增加,NAFLD现已成为我国常见的慢性肝病之一,严重危害人民健康。为进一步规范NAFLD的诊断、治疗和疗效评估,中华医学会肝病学分会脂肪肝和酒精性肝病学组组织国内有关专家,在参考国内外最新研究成果的基础上,按照循证医学的原则,制定了《非酒精性脂肪性肝病诊疗指南》(以下简称(《指南》)。其中推荐的意见所依据的证据共分为3个级别5个等次,文中以括号内斜体罗马数字表示,推荐意见的证据分级,参见Ⅸ酒精性肝病诊疗指南》表1。 | Fatty Liver and Alcoholic Liver Disease Study Group of the Chinese Liver Disease Association. | 2006 | 中华肝脏病杂志2006，14，3： | 1509 |
| 6 | 酒精性肝病诊疗指南显示文摘酒精性肝病是由于长期大量饮酒所致的肝脏疾病。初期通常表现为脂肪肝,进而可发展成酒精性肝炎、酒精性肝纤维化和酒精性肝硬化,严重酗酒时可诱发广泛肝细胞坏死甚或肝功能衰竭,该病是我国常见的肝脏疾病之一,严重危害人民健康。为进一步规范酒精性肝病的诊断和治疗,中华医学会肝病学分会脂肪肝和酒精性肝病学组组织国内有关专家,在参考国内外最新研究成果的基础上,按照循证医学的原则,制订了本《指南》。其中推荐的意见所依据的证据等级共分为3个级别5个等次,见表1,文中以括号内斜体罗马数字表示。 | Fatty Liver and Alcoholic Liver Disease Study Group of the Chinese Liver Disease Association. | 2006 | 中华肝脏病杂志2006，14，3： | 271 |
| 7 | 非酒精性脂肪性肝病诊疗指南显示文摘 | Fattly Liver and Alcoholic Liver Disease Study Group of the Chinese Liver Disease Association. | 2007 | 实用肝脏病杂志2007，10，1： | 145 |
| 8 | 2006年第二次全国残疾人抽样调查主要数据公报显示文摘 | Leading Group of the Second China National Sample Survey on Disability, National Bureau of Statistics of the People’s Republic of China | 2006 | 中国康复理论与实践2006，12，12： | 152 |
| 9 | 第二次中国临床血脂控制达标率及影响因素多中心协作研究显示文摘目的了解我国临床血脂控制的最新现状,指导临床血脂异常防治实践。方法在全国21家省部级医院和6家地县级医院中,查阅2004年1月1日至2006年2月28日间开始服调脂药物,且同一药物同一剂量维持≥2个月的2237名患者病例资料,依据美国2004年国家胆固醇教育计划(NCEP)成人治疗组第三次报告(ATPBⅢ)及《中国成人血脂异常防治指南》标准计算血脂控制达标率。结果 (1)在符合任一血脂防治建议/指南的药物起始治疗标准的2094例患者中,80%来自省部级医院,60%为60岁以上,57%有胆固醇升高,15%无血脂异常,68%合并冠心病等动脉粥样硬化性疾病,75%合并高血压,80%为高危和极高危患者,84%使用他汀类药物,83%采取了不同程度的饮食治疗。(2)依据美国2004年 NCEP ATPⅢ最新报告,总达标率为34%,低危组、中危组、中高危组、高危组和极高危组达标率分别为85%、78%、61%、3 1%和22%,差异有统计学意义(趋势性检验 P<0.001);依据我国新的《成人血脂异常防治指南》,总达标率为50%,低危组、中危组、高危组和极高危组达标率分别为91%、77%、49%和38%,组间差异及趋势性检验均有统计学意义(P<0.001)。(3)联合用药者达标率为51%,单用他汀类35%,贝特类23%,烟酸类24%,其他类28%,组间差异有统计学意义(P<0.001)。(4)对1808例服用他汀类药物患者的多元 logistic 回归分析表明,他汀类药物剂量(高剂量比低剂量,OR=1.72,95%CI:1.15~2.58)、危险分层(极高危比低危,OR=0.02,95%CI:0.01~0.03)、基线 LDL-C[每升高0.259 mmol/L(10 mg/dl),OR=0.83,95%CI:0.80~0.86]和性别(女性比男性,OR=0.77,95%CI:0.60~0.99)等是影响达标率的主要因素。结论我国目前调脂药物的应用对象发生了很大变化,调脂治疗的目的已不单纯是为了降低胆固醇。临床血脂控制状况与各防治指南要求相距仍甚远,特别是高危和极高危患者。要进一步改善我国临床血脂控制状况,药物种类、药物剂量、联合治疗和治疗性生活方式改变等多方面均需要进一步提高。 | The Collaborative Research Group for the Second Multi-center Survey of Clinical Management of Dyslipidemia in China | 2007 | 中华心血管病杂志2007，35，5： | 127 |
| 10 | 尿激酶治疗急性心肌梗塞多中心临床试验1406例总结显示文摘为观察尿激酶天普洛欣(UKTP)经静脉溶栓治疗急性心肌梗塞(AMI)的临床有效性及安全性。收集协作组148家医院1994年11月至1996年4月经静脉UKTP溶栓治疗AMI患者1406例,观察临床疗效、副作用及病死率等。其中124例行90分钟冠状动脉造影评价梗塞血管开通情况。结果:梗塞血管临床再灌注率为73.5%,90分钟冠状动脉造影血管开通率为72.6%,5周总病死率为7.8%(109/1406),轻度出血10.2%(143/1406),中重度出血0.43%(6/1406),脑出血0.50%(7/1406)。老年(>65岁)甚至高龄(>75岁)患者溶栓及距发病超过6小时者,其用药仍然安全有效,UKTP合适的用药剂量可能为150万U左右。结果提示UKTP治疗AMI安全有效。 | The collaborative study group for national multicenter clinical trial of urokinase thrombolytic therapy (Correspondence: Hu Dayi, Xu Zhimin. Beijing Red Cross Chao Yao Hospital, Beijing 100020) | 1997 | 中华心血管病杂志1997，25，3： | 139 |
| 11 | 急性病毒性心肌炎的药物治疗观察显示文摘目的 全国十二家大型医院协作观察中西医结合治疗急性病毒性心肌炎疗效。方法 对 10 2 8例临床诊断为急性病毒性心肌炎患者随机各分两组 ,治疗组 60 2例 ,用中西医结合 (黄芪、牛磺酸、泛葵利酮、抗心律失常药等)治疗 ;对照组 4 2 6例 ,用常规 (极化液、抗心律失常药等 )治疗。结果 中西医结合治疗组临床症状改善、外周血肠道病毒阴转、心电图ST T改变及房室传导阻滞、阵发性心房颤动、窦房传导阻滞等恢复均优于对照组(P <0 .0 1、0 .0 5 ) ;对早搏及心功能改善两组间无统计学差异(P <0 .0 5 )。结论 在目前对急性病毒性心肌炎无特效药物治疗的情况下 ,采用中西医结合治疗可作为一种治疗手段。 | Collaborative Group of “Key National Medical Projects for the Ninth Five Year Plan Research” (Correspondence: YANG Yingzhen, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital,Shanghai Medical University,Shanghai 200032) | 1999 | 中华心血管病杂志1999，27，6： | 94 |
| 12 | Spatiotemporal variations of vegetation cover on the Chinese Loess Plateau(1981―2006):Impacts of climate changes and human activities显示文摘Spatiotemporal variations of Chinese Loess Plateau vegetation cover during 1981-2006 have been investigated using GIMMS and SPOT VGT NDVI data and the cause of vegetation cover changes has been analyzed, considering the climate changes and human activities. Vegetation cover changes on the Loess Plateau have experienced four stages as follows: (1) vegetation cover showed a continued increasing phase during 1981―1989; (2) vegetation cover changes came into a relative steady phase with small fluctuations during 1990―1998; (3) vegetation cover declined rapidly during 1999―2001; and (4) vegetation cover increased rapidly during 2002―2006. The vegetation cover changes of the Loess Plateau show a notable spatial difference. The vegetation cover has obviously increased in the Inner Mongolia and Ningxia plain along the Yellow River and the ecological rehabilitated region of Ordos Plateau, however the vegetation cover evidently decreased in the hilly and gully areas of Loess Plateau, Liupan Mountains region and the northern hillside of Qinling Mountains. The response of NDVI to climate changes varied with different vegetation types. NDVI of sandy land vegetation, grassland and cultivated land show a significant increasing trend, but forest shows a decreasing trend. The results obtained in this study show that the spatiotemporal variations of vegetation cover are the outcome of climate changes and human activities. Temperature is a control factor of the seasonal change of vegetation growth. The increased temperature makes soil drier and unfavors vegetation growth in summer, but it favors vegetation growth in spring and autumn because of a longer growing period. There is a significant correlation between vegetation cover and precipitation and thus, the change in precipitation is an important factor for vegetation variation. The improved agricultural production has resulted in an increase of NDVI in the farmland, and the implementation of large-scale vegetation construction has led to some beneficial effect in ecology. | XIN ZhongBao1,2, XU JiongXin1 & ZHENG Wei1, 2 1 Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China 2 Graduate University of the Chinese Academy of Sciences, Beijing 100049, China | 2008 | Science China Earth Sciences2008，51，1： | 112 |
| 13 | 中华医学会感染与抗微生物治疗策略高峰论坛:甲氧西林耐药金黄色葡萄球菌感染的治疗策略——专家共识显示文摘中华医学会感染与抗微生物治疗高峰论坛:甲氧西林耐药金葡菌感染的治疗策略于2011年4月17日在长沙举行。60余位来自感染科、呼吸科、血液科、重症医学、皮肤科、普外科、烧伤科、肾病科、儿科等临床学科及医学检验科的资深专家就甲氧西林耐药金葡菌感染的病原诊断和治疗的相关问题进行了广泛深入讨论,拟定了“甲氧西林耐药金葡菌感染的治疗策略一专家共识”的内容纲要。目前国内尚缺少基于充分临床实践(循证医学)证据的治疗耐甲氧西林金葡菌(MRSA)感染的指南或专家共识可供参考。 | Expert panel of Chinese Medical Association Forum on the Strategies for the Management of Methicillinresistant Staphylococcus aureus Infections | 2011 | 中国感染与化疗杂志2011，11，6： | 94 |
| 14 | 原发性肝癌诊疗规范(2011年版)显示文摘一、概述原发性肝癌(primarylivercancer,PLC,以下简称肝癌)是常见恶性肿瘤。由于起病隐匿,早期没有症状或症状不明显,进展迅速,确诊时大多数患者已经达到局部晚期或发生远处转移,治疗困难,预后很差,如果仅采取支持对症治疗,自然生存时问很短,严重地威胁人民群众的身体健康和生命安全。 | Ministry of Health of the People’s Republic of China | 2011 | 临床肝胆病杂志2011，27，11： | 491 |
| 15 | 家庭血压监测中国专家共识显示文摘自动的电子血压计正在进入家庭。家庭血压监测已成为血压管理的重要组成部分。近年来,美国、欧洲与日本相继制定了家庭血压监测指南。我国家庭血压监测的研究工作正处起步阶段,尚不能完全根据我国相关研究的结果制定指南。随着高血压患者家庭血压管理意识的迅速提高,许多家庭拥有了自动的电子血压计,同时也在进行家庭血压测量。为了促进家庭血压监测的健康发展,需要对家庭血压监测进行适当的规范。因此,参考国外有关指南并经广泛、深入的讨论,制定本共识文件。就血压计的选择与校准、血压测量的频率(次数)与时间(天数)以及家庭血压的正常值等重要问题提出了建议。 | Chinese Hypertension Committee of the Chinese Medical Doctors Association, Chinese Hypertension League, Chinese Society of Cardiology of the Chinese Medical Association | 2012 | 中华高血压杂志2012，20，6： | 83 |
| 16 | 糖尿病足诊治指南显示文摘糖尿病足是糖尿病严重而又治疗费用高的慢性并发症。该文系统介绍糖尿病足的基本概念,糖尿病下肢缺血与下肢动脉硬化合并糖尿病的区别,糖尿病病变的特点与预后。着重介绍糖尿病足的治疗,包括下肢动脉介入治疗、动脉旁路重建、干细胞,移植。对大动脉、中等动脉和小动脉治疗方案的选择,以及围手术期处理等都进行了详细的论述。 | China Branch of the International Union of Angiology Diabetic Foot Committee | 2013 | 介入放射学杂志2013，22，9： | 269 |
| 17 | MAPK signal pathways in the regulation of cell proliferation in mammalian cells显示文摘MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. At least three MAPI(families have been characterized: extracellular signal-regulated kinase (ERK), Jun kinase (JNK/SAPK) and p38 MAPK. The above effects are fulfilled by regulation of cell cycle engine and other cell proliferation related proteins. In this paper we discussed their functions and cooperation with other signal pathways in regulation of cell proliferation. | WEI ZHANG, Hui Tu LIU The Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, China | 2002 | Cell Research2002，12，1： | 107 |
| 18 | Predictive Values of Body Mass Index and Waist Circumference for Risk Factors of Certain Related Diseases in Chinese Adults - Study on Optimal Cut-off Points of Body Mass Index and Waist Circumference in Chinese Adults显示文摘Objective For prevention of obesity in Chinese population, it is necessary to definethe optimal range of healthy weight and the appropriate cut-off points of BMI and waistcircumference for Chinese adults. The Working Group on Obesity in China under the supportof International Life Sciences Institute Focal Point in China organized a meta-analysis on therelation between BMI, waist circumference and risk factors of related chronic diseases (e. g.,high diabetes, diabetes mellitus, and lipoprotein disorders). Methods 13 population studiesin all met the criteria for enrollment, with data of 239 972 adults (20-70 year) surveyed inthe 1990s. Data on waist circumference was available for 111411 persons and data on serumlipids and glucose were available for more than 80 000. The study populations located in21provinces, municipalities and autonomous regions in China's Mainland as well as inTaiwan. Each enrolled study provided data according to a common protocol and uniformformat. The Center for data management in Department of Epidemiology, Fu Wai Hospitalwas responsible for statistical analysis. Results and conclusion The prevalence ofhypertension, diabetes, dyslipidemia and clustering of risk factors all increased withincreasing levels of BMI or waist circumference. BMI at 24 with best sensitivity andspecificity for identification of the risk factors, was recommended as the cut-off point foroverweight, BMI at 28 which may identify the risk factors with specificity around 90 % wasrecommended as the cut-off point for obesity. Waist circumference beyond 85 cm for menand beyond 80 cm for women were recommended as the cut-off points for central obesity.Analysis of population attributable risk percent illustrated that reducing BMI to normalrange (<24) could prevent 45%-50% clustering of risk factors. Treatment of obese persons(BMI≥28)with drugs could prevent 15%-17% clustering of risk factors. The waistcircumference controlled under 85 cm for men and under 80 cm for women, could prevent47%-58% clustering of risk factors. According to these, a classification of overweight andobesity for Chinese adults is recommended. | ZHOU BEI-FAN2Cooperative Meta-Analysis Group of the Working Group on Obesity in China | 2002 | Biomedical and Environmental Sciences2002，15，1： | 237 |
| 19 | 2015年全国细菌耐药监测报告显示文摘为贯彻落实《抗菌药物临床应用指导原则》,加强医疗机构抗菌药物临床应用的监督和管理,国家卫生计生委合理用药专家委员会和全国细菌耐药监测网日前发布了《2015年全国细菌耐药监测报告》,现予全文刊登,以促进合理用药,提高抗菌药物临床应用水平。 | Committee of Experts on Rational Drug Use, National Health and Family Planning Commission of the P.R.China | 2016 | 中国执业药师2016，0，3： | 206 |
| 20 | 手足口病诊疗指南(2018年版)显示文摘手足口病(hand foot and mouth disease,HFMD)是由肠道病毒(enterovirus,EV)感染引起的一种儿童常见传染病,5岁以下儿童多发。手足口病是全球性疾病,我国各地全年均有发生,发病率为37.01/10万-205.06/10万,近年报告病死率在6.46/10万-51.00/10万之间。为进一步规范和加强手足口病的临床管理。 | National Health Commission of the People′s Republic of China | 2018 | 中国病毒病杂志2018，8，5： | 162 |
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