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| 1 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 2 | Super d-antimagic Labelings of Disconnected Plane Graphs显示文摘这份报纸处理以如此的一个方法把一张飞机图的顶点,边和脸标记,一张脸的标签和包围那张脸的顶点和边的标签总和为那张脸的重量的问题,并且所有 站在一起s 的脸的重量组成差别 d 的算术前进,为每 s ,那出现在图。纸检验如此的标记的存在为拆散飞机图的联合。 | Martin BAA Mirka MILLER Oudone PHANALASY Andrea SEMANIOV-FEOVKOV | 2010 | Acta Mathematica Sinica,English Series2010，26，12： | 2 |
| 3 | Bacterial vaginosis in early pregnancy and pregnancy outcome 显示文摘 | Kurki T Sivonen A Renkonen OV | 1992 | Obstet Gynecol1992，80，2： | 1 |
| 4 | Influence of effluent irrigation on community composition and function of ammonia-oxidi-zing bac- teria in soi显示文摘 | Oved T Shaviv A Goldrath T | 2001 | Appl Environ Microbiol2001，67，： | 1 |
| 5 | Role of plant growth promotingrhizobacteria in the remediation of metal contaminated soils 显示文摘 | Khan MS Zaidi A Wani PA Oves M | 2009 | EnvironChem Lett2009，7，1： | 1 |
| 6 | Influence of effluent irrigation on community composition and function of ammonia- oxidizing bacteria in soil显示文摘 | Oved T Shaviv A Goldrath T | 2001 | Appl Environ Mierob2001，67，8： | 1 |
| 7 | Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptanemal complexes显示文摘 | Kovalenko OV Plug A Haaf T | 1996 | Proc Natl Acad Sci USA1996，93，： | 1 |
| 8 | Gas-phase dehydration of glycerol to acrolein catalysed by caesium heteropoly salt显示文摘 | ALHANASH A KOZHEVNIKOVA E F KOZHEVNIK- OV I V | 2010 | Appl Catal A: General2010，378，： | 1 |
| 9 | A reinvestigation of the structure of biruloquinone, a 9,10-phenanthrenequinone isola- ted from Mycosphaerella rubella 显示文摘 | Armone A Nasini G de Para OV | 1991 | Phytochemistry1991，31，： | 1 |
| 10 | Cyclooxygenase-2: a therapeutic target in angiogenesis 显示文摘 | Iniguez MA Rodriguez A Volpert OV | 2003 | Trends Mol Med2003，9，2： | 1 |
| 11 | Susceptibility to neurodegeneration in a glaucoma is modi- fied by Bax gene dosage 显示文摘 | Libby RT Li Y Savinova OV Barter J Smith RS Nickells RW et a/ | 2005 | PLoS Genet2005，1，1： | 1 |
| 12 | Extraction separation of strontium and yttrium radionuclides by hydrogen heptachlorodicarbollylcobaltate in the presence of benzo-15-crown-5显示文摘 | Vaňura P Jedináková-K?í?ová V Yoshioka A | 2002 | Journal of Radioanalytical and Nuclear Chemistry2002，251，3： | 1 |
| 13 | Radioimmunotherapy for prostate cancer-current status and future possibilities显示文摘 | Evans-Axelsson S Timmermand OV Bjartell A | 2016 | Semin Nucl Med2016，46，2： | 1 |
| 14 | Keratinocyte growth factor ameliorates acute graft-versus-host disease in a novel nonmyeloablative haploidentical transplantation model 显示文摘 | Vanclee A Lutgens L C Oving E B | 2005 | Bone Marrow Transplant2005，36，10： | 1 |
| 15 | Bacterial vaginosis in early pregnancy and pregnant outeome显示文摘 | Kurki T Sironen A Renkonen OV | 1992 | Gynecol1992，80，： | 1 |
| 16 | Influence of effluent irrigation on community composition and function of ammonia- oxidizing bacteria in soil 显示文摘 | OVED T SHAVIV A GOLDRATH T MANDELBAUM R T MINZ D | 2001 | Applied and Environmental Microbiology2001，67，8： | 1 |
| 17 | Clinical study of fetal mesencephalic intracerebral transplants for the treatment of Parkinson's disease显示文摘 | Kopyov OV Jacques D Lieberman A | 1996 | Cell Transplantation1996，5，2： | 1 |
| 18 | Bacterial vaginosis in early pregnancy and pregnancy outcome显示文摘 | Kurki T Sivonen A Renkonen OV | 2002 | Obsent Gynecol2002，80，： | 1 |
| 19 | Shear wave elasticity imaging: A new ultrasonic technology of medical diagnostics 显示文摘 | Sarvazyan A Rudenko OV Swanson SD | 1998 | Ultrasound Med Biol1998，24，9： | 1 |
| 20 | Effect of photoactive dye on bacteria contained in activated sludge显示文摘 | Smolinskáa M Taká(c) ováa A | | 0，，02： | 1 |
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