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1Delaying surgery after neoadjuvant chemoradiotherapy improves prognosis of rectal cancer显示文摘AIM To investigate the prognostic effect of a delayed interval between neoadjuvant chemoradiotherapy(CRT) and surgery in locally advanced rectal cancer.METHODS We evaluated 87 patients with locally advanced mid-or distal rectal cancer undergoing total mesorectal excision following an interval period after neoadjuvant CRT at ?i?li Hamidiye Etfal Training and Research Hospital,Istanbul between January 2009 and January 2014.Patients were divided into two groups according to the intervalbefore surgery: < 8 wk(group Ⅰ) and ≥ 8 wk(group Ⅱ).Data related to patients,cancer characteristics and pathological examination were collected and analyzed.RESULTS When the distribution of timing between group Ⅰ(n = 45) and group Ⅱ(n = 42) was viewed,comparison of interval periods(median ± SD) of groups showed a significant difference of as 5 ± 1.28 wk in group Ⅰ and 10.1 ± 2.2 wk in group Ⅱ(P < 0.001).The median follow-up period for all patients was 34.5(9.9-81) mo.group Ⅱ had significantly higher rates of pathological complete response(p CR) than group Ⅰ had(19% vs 8.9%,P = 0.002).Rate of tumor regression grade(TRG) poor response was 44.4% in group Ⅰ and 9.5% in group Ⅱ(P < 0.002).A poor pathological response was associated with worse disease-free survival(P = 0.009).The interval time did not show any association with local recurrence(P = 0.79).CONCLUSION Delaying the neoadjuvant CRT-surgery interval may provide nodal down-staging,improve p CR rate,and decrease the rate of TRG poor response.Mehmet Mihmanli Esin Kabul Gürbulak Ismail Ethem Akgün Mustafa Fevzi Celayir Pinar Yazici Deniz Tuncel Tuba Tülin Bek Ayhan Oz Sinan Omeroglu 2016World Journal of Gastrointestinal Oncology2016,8,9:3
2Differentialinteraction of the tyrosine phosphatases PTP-SL,STEP andHePTP with the mitogen-activated protein kinases ERK1/2and p38alpha is determined by a kinase specificity sequenceand influenced by reducing agents显示文摘Mu oz JJ Tárrega C Blanco-Aparicio C etal 2003Biochem J2003,372,1:1
3CT angiography of the renal arteries and veins: normal anatomy and variants 显示文摘Hazlrotan T Oz M Turkbey B 2011Diagn Interv Radiol2011,17,1:1
4Pregnancy outcome after cyclosporine therapy during pregnancy: a meta-analysis 显示文摘Bar Oz B Hackman R Einarson T 2001Transplantation2001,71,8:1
5Inhibition of volatile fatty acid production in granular sludge from a UASB reactor显示文摘Dogan T Ince O Oz N A 2005EnvironTechnol2005,40,3:1
6Functional tolerance and blockade of long-term depression at synapses in the nucleus accumbens after chronic cannabinoid exposure 显示文摘HOFFMAN AF OZ M CAULDER T 2003J Neurosci2003,23,12:1
7Totally endoscopic atrial septal defect repair with robotic assistance显示文摘Argenziano M Oz MC Kohmoto T 2003Circulation2003,108,11:1
8Effects of immunomodulators on acute Trypanosoma cruzi infection in mice显示文摘Oz H S Hughes W T Thomas E K 2002Med Sei Monit2002,8,6:1
9A model for chronic mucosal inflammation in IBD and periodontitis显示文摘Oz HS Chen T Ebersole JL 0,,08:1
10Comparison of meconium and neonatal hair analysis for detection of gestational exposure to drugs of abuse显示文摘Bar - Oz B Klein J Karaskov T 2003Arch Dis Child Fetal Neonatal Ed2003,88,2:1
11Changes in bone den- sity and bone markers in rhythmic gymnasts and ballet dancers: implications for puberty and leptin levels显示文摘Mu~oz M T de la Piedra C Barrios V 2004Eur J Endocrinol2004,151,4:1
12Melatonin protects against renal oxidative stress after obstructive jaundice in rats显示文摘Adolfo Cruz Francisco J Padillo Isaac Túnez Carmen Mu?oz Jose Granados Carlos Pera-Madrazo Pedro Montilla 2001European Journal of Pharmacology2001,,2:1
13Eph/Ephrin-mediated interactions in the thymus显示文摘Muoz J J Cejalvo T Alonso-Colmenar L M  2011Neuroimmunomodulation2011,18,5:1
14Effects of dietary carnitine and protein energy:nonprotein energy ratios on growth,ammonia excretion and respiratory quotient in African catfish,Clarias gariepinus (Burchell) juveniles显示文摘Ozório R O A Eekeren T H B Huisman E A 0,,01:1
15The relationship be- tween retinal nerve fiber layer thickness and carotid in- tima media thickness in patients with type 2 diabetes mellitus显示文摘Sahin SB Sahin OZ Ayaz T 2014Diabetes Research and Clinical Practice2014,106,3:1
16A study of neural network based inverse kinematics solution for a three-joint robot显示文摘KOKER R OZ C CAKAR T 2004Robotics and Autonomous Systems2004,49,34:1
17The expression of astroglial glutamate transporters in patients with focal cortical dysplasia: an immunohistochemical study 显示文摘Ulu MO Tanriverdi T Oz B 2010Acta Neuroehir (Wien)2010,152,5:1
18Short - term effects of perio- dontal therapy as an adjunct to anti - lipemic treatment 显示文摘Fento lu O Szen T Oz SG 2010Oral Dis2010,16,7:1
19An adaptive filtering algorithm using an orthogonal projection to an affine subspace and its properties显示文摘Ozeli K Umeda T 1984Electron Commun1984,,:1
20Possible increased risk for Alzheimer’s disease associated with neprilysin gene显示文摘J. Clarimón F. J. Mu?oz M. Boada L. Tàrraga J. Sunyer J. Bertranpetit D. Comas 2003Journal of Neural Transmission2003,,6:1
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