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| 1 | Subclinical carotid atherosclerosis predicts all-cause mortality and cardiovascular events in obese patients with negative exercise echocardiography显示文摘BACKGROUND Obesity is a major health problem due to its high prevalence. The relationship between obesity and cardiovascular disease is unclear. Some studies agree that certain conditions associated with obesity, such as physical inactivity or cardiovascular risk factors, are responsible for cardiovascular risk excess among obese people. Carotid intima-media thickness and carotid plaques(CP) have been associated with cardiovascular adverse events in healthy populations, and recent data suggest a higher prevalence of subclinical carotid atherosclerosis in obese and metabolically unhealthy patients. However, there are no studies correlating subclinical atherosclerosis and adverse events(AE) in obese subjects.AIM To determine the association between carotid disease and AE in obese patients with negative exercise echocardiography(EE).METHODS From January 1, 2006 to December 31, 2010, 2000 consecutive patients with a suspicion of coronary artery disease were submitted for EE and carotid ultrasonography. Exclusion criteria included previous vascular disease, left ventricular ejection fraction < 50%, positive EE, significant valvular heart disease and inferior to submaximal EE. An AE was defined as all-cause mortality,myocardial infarction and cerebrovascular accident. Subclinical atherosclerosis was defined as CP presence according to Manheim and the American Society of Echocardiography Consensus.RESULTS Of the 652 patients who fulfilled the inclusion criteria, 226(34.7%) had body mass indexes ≥ 30 kg/m2, and 76 of them(33.6%) had CP. During a mean follow-up time of 8.2(2.1) years, 27 AE were found(11.9%). Mean event-free survival at 1, 5 and 10 years was 99.1%(0.6), 95.1%(1.4) and 86.5%(2.7), respectively. In univariate analysis, CP predicted AE [hazard ratio(HR) 2.52, 95% confidence interval(CI) 1.17-5.46; P = 0.019]. In multivariable analysis, the presence of CP remained a predictor of AE(HR 2.26, 95%CI 1.04-4.95, P = 0.041). Other predictors identified were glomerular filtration rate(HR 0.98, 95%CI 0.96-0.99; P= 0.023), peak metabolic equivalents(HR 0.83, 95%CI 0.70–0.99, P = 0.034) and moderate mitral regurgitation(HR 5.02, 95%CI 1.42–17.75, P = 0.012).CONCLUSION Subclinical atherosclerosis defined by CP predicts AE in obese patients with negative EE. These patients could benefit from aggressive prevention measures. | Rafael Vidal-Perez Raúl Franco-Gutiérrez Alberto J Pérez-Pérez Virginia Franco-Gutiérrez Alberto Gascón-Vázquez Andrea López-López Ana María Testa-Fernández Carlos González-Juanatey | 2019 | World Journal of Cardiology2019，11，1： | 7 |
| 2 | Pharmacological properties of Anagallis arvensis L. (“scarlet pimpernel”) and Anagallis foemina Mill. (“blue pimpernel”) traditionally used as wound healing remedies in Navarra (Spain)显示文摘 | Víctor López Anna K. J?ger Silvia Akerreta Rita Yolanda Cavero Maria Isabel Calvo | 2011 | Journal of Ethnopharmacology2011，，3： | 2 |
| 3 | Factors that impact health-related quality of life in adults with celiac disease:A multicenter study显示文摘AIM: To evaluate the factors involved in the impairment of health-related quality of life (HRQOL) in patients with celiac disease.METHODS: A multicenter, cross-sectional prospective study was performed in patients with celiac disease who completed two HRQOL questionnaires: the gastrointestinal quality of life index (GIQLI) and the EuroQol-5D (EQ).RESULTS: Three hundred and forty patients (163 controlled with a gluten-free diet, and 177 newly diagnosed with a normal diet) were included. The GIQLI score was significantly better in patients on a gluten-free diet (GFD) than in non-treated patients on their usual diet, both in terms of the overall score (3.3 vs 2.7, respectively; P < 0.001), as well as on the individual questionnaire dimensions. Both the preference value of the EQ as the visual analogue scale were significantly better in treated than in non-treated patients (0.93 vs 0.72 P < 0.001 and 80 vs 70 P < 0.001, respectively). Variables significantly associated with a worse HRQOL score were female gender, failure to adhere to a GFD, and symptomatic status.CONCLUSION: In untreated celiac disease, the most important factors that influence patient perception of health are the presence of symptoms and a normal diet. HRQOL improves to levels similar to those described in the general population in celiac disease patients well controlled with a GFD. | F Casellas L Rodrigo J López Vivancos S Riestra C Pantiga JS Baudet F Junquera V Puig Diví C Abadia M Papo J Gelabert JR Malagelada | 2008 | World Journal of Gastroenterology2008，14，1： | 2 |
| 4 | Advances in the preparation of magnetic nanoparticles by the microemulsion method显示文摘 | LO' PEZ PE' REZ J A LO' PEZ QUINTELA M A MIRA J | 1997 | J Phys Chem B1997，101，41： | 1 |
| 5 | A case series of the use of the ProSeal laryngeal mask airway in emergency lower abdominal surgery显示文摘 | Fabregat-López J Garcia-Rojo B Cook TM | 2008 | Anaesthesia2008，63，9： | 1 |
| 6 | Technique and complications of percutaneous nephroscopy:experience with 557 patients in the supine position显示文摘 | Valdivia Uría JG Valle Gerhold J López López JA | 1998 | J Urol1998，160，61： | 1 |
| 7 | Bedside evaluation of pressure-volume curves in patients with acute respiratory distress syndrome显示文摘 | Blanch L López Aguilar J Villagrá A | | 0，，03： | 1 |
| 8 | Bio-ethanol steam reforming and autothermal reforming in 3-μm channels coated with Rh Pd/Ce O2for hydrogen generation显示文摘 | Divins N J López E Rodríguez | 2013 | Chem Eng Process2013，64，： | 1 |
| 9 | Concurrent clarithromycin and cyclosporine A treatment显示文摘 | Sádaba B López de Ocáriz A Azanza J R | 1998 | J Antimicrob Chemother1998，42，3： | 1 |
| 10 | Classification tree analysis for the discrimination of pleural exudates and transudates显示文摘 | Esquerda A Trujillano J López de Ullibarri I | 2007 | Clin Chem Lab Med2007，45，1： | 1 |
| 11 | Influence of sodium fumarate addition on rumen fermentation in vitro显示文摘 | López S Valdes C Newbold C J | 1999 | British Journal of Nutrition1999，81，： | 1 |
| 12 | Changes in transcrption within the CA1 field of the hippocampus areassociated with age-related spatial learning impairments显示文摘 | Burger C López M C Feller J A | 2007 | Neurobiol Learn Mem2007，87，1： | 1 |
| 13 | Adsorption of paraquat on soil organic matter:Effect of exchangeable cations and dissolved organic carbon显示文摘 | Gondar D López R Antelo J | | 0，，： | 1 |
| 14 | Flexible ureterorenoscopy(URS):technique and results显示文摘 | Cansino Alcaide JR Reinoso Elbers J López Sánchez D | 2010 | Archivos Espa?oles de Urología2010，，10： | 1 |
| 15 | The HIF-1-inducible lysyl oxidase activates HIF-1 via the Akt pathway in a positive regulation loop and synergizes with HIF-1 in promoting tumor cell growth显示文摘 | Pez F Dayan F Durivault J | | 0，，5： | 1 |
| 16 | Multiresidue determination of organophosphorus and organochlorine pesticides in human biological fluids by capillary gas chromatography显示文摘 | Pitarch E Lpez F J Serrano R | 2001 | J Anal Chem2001，369，： | 1 |
| 17 | Oxidative dehydrogenation of ethane on Te-containing MoVNbO catalysts显示文摘 | L(O)PEZ NIETO J M BOTELLA P CONCEPCI(O)N P | 2004 | Catal Today2004，9192，： | 1 |
| 18 | Antibacterial activity of different essential oils obtained from spices widely used in Mediterranean diet显示文摘 | Viuda-Martos M Ruiz-Navajas Y Fernández-López J | | 0，，03： | 1 |
| 19 | Tea polyphenol epigallocatechin-3-gallate inhibits ergosterol synthesis by disturbing folic acid metabolism in Candida albicans显示文摘 | Navarro-Martínez M D García-Cánovas F Rodríguez-López J N | 2006 | Journal of Antimicrobial Chemotherapy2006，57，6： | 1 |
| 20 | Phosphate starvation induces a determinate developmentalprogram in the roots of Arabidopsis thaliana显示文摘 | Sánchez-Calderón L López-Bucio J Chacón-López A | 2005 | Plant CellPhysiol2005，46，1： | 1 |
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