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| 1 | BCLC策略:预后预测和治疗推荐2022版更新显示文摘2018版BCLC预后和治疗推荐策略发布后,肝细胞癌(简称HCC)的研究又取得了重大进展。本次更新基于肝癌各领域的研究进展结果。重点关注影响策略的重要研究进展。虽然近年的研究结果成绩斐然,但将其引入为临床医生和研究者提供行动依据的循证模型指南来说证据效力依然不够确切。本文对该问题进行分析,阐述了为HCC患者制定个体化治疗临床决策所需的批判性思维和专业知识。 | Reig M Forner A Rimola J Ferrer-Fabrega J Burrel M Garcia-Criado A Kelley RK Galle PR Mazzaferro V Salem R Sangro B Singal AG Vogel A Fuster J Ayuso C Bruix J 刘永凡(摘译) 崔笑(摘译) 耿小平(审校) | 2022 | 肝胆外科杂志2022，30，5： | 80 |
| 2 | Synthesis and antibacterial evaluation of 2-substituted-4,5-diphenyl-N-alkyl imidazole derivatives显示文摘Objective:To synthesis 2-substituted-4,5-diphenyl-N- alkyl imidazole derivatives,and evaluate their antibacterial activity.Methods:A mixture of benzil(10 mmol) and ammonium acetate(0.1 mol)(immediately fused) in glacial acetic acid(25 mL) was stirred at 80-100℃for 1 h under nitrogen atmosphere(to prevent incorporation of any atmospheric impurities and moisture). Substituted aldehydes(10 mmol) in glacial acetic acid(5 mL) was added drop-wise over a period of 15-20 min at the same temperature and stirred for another 4 h,the progress of the reaction was monitored by TLC test using ethyl acetate as eluent.The newly synthesized compounds were characterized by IR,1HNMR,13CNMR and by mass spectroscopy.Results:All the synthesized compounds were confirmed by spectroscopical techniques and evaluated for antimicrobial activity against Staphylococcus aureus(S.aurius),Bacilus subtilus(B.subtilus),and Escheria coli (E.coli).These compounds showed antibacterial activity(zone of inhibition) against S.aurius ranged from 3 mm to 9 mmin diameter,B.subtilus,4 -8 mm,and E.coli 5 -12 mm.Out of 2a-2e, only 2a and 2b showed some sort of activity but none of them had considerable activity compared with that of the standard.Conclusions:All the synthesized compounds show moderate activity against the tested bacteria S.aurius,B.subtilus,and E.coli.So,further structural modification is necessary to improve the antibacterial action of 2-substituted-4,5-diphenyl-N-alkyl imidazole derivatives. | Abhishek K Jain V Ravichandran Madhvi Sisodiya RK Agrawal | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，6： | 3 |
| 3 | Kinetic analysis of wildtype and YMDD mutant Hepatitis B virus polymerases and effects of deoxyribonucleiotide concentrations on polymerase activity显示文摘 | Gaillard RK Barnard J Lopez V | 2002 | Antimicrob Agents Chemother2002，46，4： | 1 |
| 4 | Notch signaling induces cell cycle arrest in small cell lung cancer cells 显示文摘 | Sriuranpong V Borges MW Ravi RK | 2001 | Cancer Res2001，61，7： | 1 |
| 5 | Mangement of brain abcess: an overview显示文摘 | Moopthy RK Rajshekhar V | 2008 | Neurosurg Focus2008，24，6： | 1 |
| 6 | Helicobacter pyloridiagnosis andmanagement显示文摘 | Vilaichone RK Mahachai V Grahan DY | 2006 | Gastroenteroc Clin NorthAm2006，35，2： | 1 |
| 7 | Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC显示文摘 | Rubio-Cabezas 0 Puri V Murano I Saudek V Semple RK Dash S | 2009 | Emho Mol Med2009，，5： | 1 |
| 8 | The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake显示文摘 | Hvidberg V Jacobsen C Strong RK | | 0，，： | 1 |
| 9 | Synovial sheath cell migratory response to flexor tendon injury:an experimental study in rats显示文摘 | Harrison RK Mudera V Grobbelaar AO | 2003 | J Hand Surg [Am]2003，28，6： | 1 |
| 10 | Management of nutritional rickets in Indian children: a randomized controlled trial 显示文摘 | Aggarwal V Seth A Marwaha RK | 2013 | J Trop Pediatr2013，59，2： | 1 |
| 11 | Development of glioblastoma mutiforme following traumatic cerebral contusion: case report and review of literature显示文摘 | Moorthy RK Rajshekhar V | 2004 | Surg Neurol2004，61，2： | 1 |
| 12 | comparison of epidural fentanyl versus sufentanil for analgesia in ambulatory patients in early labor显示文摘 | Connelly NR Parker RK Vallurupalli V | 2000 | Anesth Analg2000，91，2： | 1 |
| 13 | VEGF and VEGF type C piay an important role in angiogenesis and lymphangiogenesis in human malignant mesothelioma tumours显示文摘 | Shridhar V Bright RK | 1999 | Br J Cancer1999，81，1： | 1 |
| 14 | Thoracic endometriosis:A case report and literature review显示文摘 | Ziedalski TM Sankaranarayanan V Chitkara RK | 2004 | J Thorac Cardiovasc Surg2004，127，： | 1 |
| 15 | Effects of lead (Pb)exposure during gestation and lactation on female pubertal development in the rat显示文摘 | Dearth RK Hiney JK Srivastava V | 2002 | Reprod Toxicol2002，16，4： | 1 |
| 16 | Notch signaling induces cell cycle arrest in small cell lung cancer cells显示文摘 | Sriuranpong V Borges MW Ravi RK | 2001 | Cancer Res2001，61，7： | 1 |
| 17 | Development of glioblastoma mutiforme following traumatic cerebral contusion:case report and review of literature显示文摘 | MOORTHY RK RAJSHEKHAR V | 2004 | Surg Neurol2004，61，2： | 1 |
| 18 | Effect of catalyst and polymerization conditions on the preparation of low molecular weight lactic acid polymers显示文摘 | Hiltunen K Seppǎlǎ J V Hǎrkǎnen M | 1997 | Macromolecules1997，30，： | 1 |
| 19 | Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer 显示文摘 | Singh A Misra V Thimmulappa RK | 2006 | PLoS Med2006，3，10： | 1 |
| 20 | Notch signaling induces cell cycle arrest in small cell lung cancer cells 显示文摘 | Sriuranpong V Borges MW Ravi RK | 2001 | Cancer Res2001，61，7： | 1 |
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