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| 1 | Caspase-3 activation as a bifurcation point between plasticity and cell death显示文摘Death-mediating proteases such as caspases and caspase-3 in particular,have been implicated in neurodegenerative processes,aging and Alzheimer's disease.However,emerging evidence suggests that in addition to their classical role in cell death,caspases play a key role in modulating synaptic function.It is remarkable that active caspases-3,which can trigger widespread damage and degeneration,aggregates in structures as delicate as synapses and persists in neurons without causing acute cell death.Here,we evaluate this dichotomy,and discuss the hypothesis that caspase-3 may be a bifurcation point in cellular signaling,able to orient the neuronal response to stress down either pathological/apoptotic pathways or towards physiological cellular remodeling.We propose that temporal,spatial and other regulators of caspase activity are key determinants of the ultimate effect of caspase-3 activation in neurons.This concept has implications for differential roles of caspase-3 activation across the lifespan.Specifically,we propose that limited caspase-3 activation is critical for synaptic function in the healthy adult brain while chronic activation is involved in degenerative processes in the aging brain. | Shikha Snigdha Erica D Smith G Aleph Prieto Carl W Cotman | 2012 | Neuroscience Bulletin2012，28，1： | 91 |
| 2 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 3 | Selection of new banana varieties for the cool subtropics in Australia显示文摘 | SMITH M K HAMILL S D LANGDON P W | 1998 | Acta Hort1998，490，： | 2 |
| 4 | Novel 1xN and NxN Integrated Optical Switches Using Self-lmaging Multimode GaAs/Al-GaAs Waveguides显示文摘 | Jenkins R M Heaton J M Wright D R Parker J T Birbeck J C H Smith G W Hilton K P | 1994 | Appl Phys Lett 71994，64，： | 1 |
| 5 | Predicting rainfall erosion losses: a guide to conservation planning显示文摘 | Wischmeier W H Smith D D | 1978 | US Department of Agriculture Agriculture Handbook1978，537，： | 1 |
| 6 | Scavenger receptor-BI inhibits ATP-binding cassette transporter 1-mediated choles-terol efflux in macrophages显示文摘 | CHEN W SILVER D L SMITH J D | 2000 | J Biol Chem2000，275，30： | 1 |
| 7 | A mechanism for divalent cation regulation of beta 3-integrins显示文摘 | Smith J W Piotrowicz R E Mathis D | 1994 | J Bio Chem1994，269，： | 1 |
| 8 | Negative thermal expansion, a review 显示文摘 | Miller W smith C W Mackenzie D S | 2009 | J Mater Sci2009，44，： | 1 |
| 9 | Fetal protection against bovine viral diarrhea virus types 1 and 2 after the use of a modified-live virus vaccine显示文摘 | XUE W MATTICK D SMITH L | 2009 | Can J Vet Res2009，73，4： | 1 |
| 10 | Development of an immunoassay for theβ-adrenergic agonist ractopamine显示文摘 | Shelver W L Smith D J | 2000 | Journal of Immunoassay andImmunochemistry2000，21，1： | 1 |
| 11 | Compositional diversity of Late Cenozoic basalts in a transect across the southern Washington Cascades: Implications for subduction zone magmatism显示文摘 | Leeman W P Smith D R Hildreth W | 1990 | Journal of Geophysical Research1990，95，19： | 1 |
| 12 | Cardioprotection with kappa - opioid receptor stimulation is associated with a slowing of cross -bridge cycling显示文摘 | Pyle W G Smith T D Hofmann P A | 2000 | Am J Physiol Heart Circ Physiol2000，279，4： | 1 |
| 13 | An organizational climate regarding ethics: The outcome of leader values and practices that reflect them 显示文摘 | DICKSON M W SMITH D B GROJEAN M W EHRHART M | 2001 | Leadership Quarterly2001，12，2： | 1 |
| 14 | Increased expression of bioactive chemokines in human cerebromicrovascular endothelial cells and astrocytes subjected to simulated ischemia in vitro显示文摘 | Zhang W D Smith Catherine Shapiro Anthony | 1999 | J Neuroimmunology1999，101，2： | 1 |
| 15 | NEMO Satellite Sensor Imaging Payload 显示文摘 | Myers W A Smith R D Stuart J L | 1998 | Proceeding of SPIE1998，3437，： | 1 |
| 16 | The ASA framework: An update显示文摘 | Schneider B Goldstein H W and Smith D B | 1995 | Personnel Psychology1995，48，4： | 1 |
| 17 | RAPD marker and isozyme characterization of Sphaeropsis sapinea from diverse coniferous hosts and locations 显示文摘 | Stanosz G R Swart W J Smith D R | 1999 | Mycological Research1999，103，9： | 1 |
| 18 | On the Corporate Demand for Insurance 显示文摘 | Mayers D C W Smith | 1982 | Journal of Business1982，55，： | 1 |
| 19 | Linustatin and neolinustatin: cyanogenic glycosides of linseed meal that protect animals against selenium toxic- ity显示文摘 | Smith C R D Weisleder R W Miller | 1980 | JOrgChem1980，45，： | 1 |
| 20 | On the dependence of sea surface roughness on wave development显示文摘 | Donelan M A Dobson F W Smith S D | 1993 | J Phys Oceanogr1993，23，9： | 1 |
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