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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Internal nutrient efficiencies of irrigated lowland rice in tropical and subtropical Asia显示文摘 | C Witt A Dobermann S Abdulrachman H.C Gines Wang Guanghuo R Nagarajan S Satawatananont Tran Thuc Son Pham Sy Tan Le Van Tiem G.C Simbahan D.C Olk | 1999 | Field Crops Research1999，，2： | 2 |
| 3 | Promotion of Pt/γ-Al2O3 by Ce for preferential oxidation of CO in H2显示文摘 | Son I H Lane A M | 2001 | Catalysis Letters2001，176，34： | 2 |
| 4 | Cancer-associated fibroblast-derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib显示文摘Background:Cancer-associated fibroblasts(CAFs)play an important role in the induction of chemo-resistance.This study aimed to clarify the mechanism underlying CAF-mediated resistance to two tyrosine kinase inhibitors(TKIs),sorafenib and lenvatinib,and to identify a novel therapeutic target for overcoming TKI resistance in hepatocellular carcinoma(HCC).Methods:We performed a systematic integrative analysis of publicly available gene expression datasets and whole-transcriptome sequencing data from 9 pairs of CAFs and para-cancer fibroblasts isolated from human HCC and para-tumor tissues,respectively,to identify key molecules that might induce resistance to TKIs.We then performed in vitro and in vivo experiments to validate selected targets and related mechanisms.The associations of plasma secreted phosphoprotein 1(SPP1)expression levels before sorafenib/lenvatinib treatment with progression-free survival(PFS)and overall survival(OS)of 54 patients with advanced HCC were evaluated using Kaplan-Meier and Cox regression analysis.Results:Bioinformatic analysis identified CAF-derived SPP1 as a candidate molecule driving TKI resistance.SPP1 inhibitors reversed CAF-induced TKI resistance in vitro and in vivo.CAF-derived SPP1 activated rapidly accelerated fibrosarcoma(RAF)/mitogen-activated protein kinase(MAPK)and phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)through the integrin-protein kinase C-alpha(PKCα)signaling pathway and promoted epithelial-to-mesenchymal transition(EMT).A high plasma SPP1 level before TKI treatment was identified as an independent predictor of poor PFS(P=0.026)and OS(P=0.047)in patients with advanced HCC after TKI treatment.Conclusions:CAF-derived SPP1 enhances TKI resistance in HCC via bypass activation of oncogenic signals and EMT promotion.Its inhibition represents a promising therapeutic strategy against TKI resistance inHCC.Moreover,plasma SPP1 level before TKI treatment represents a potential biomarker for treatment response prediction. | JungWoo Eun Jung Hwan Yoon Hye Ri Ahn Seokhwi Kim Young Bae Kim Su Bin Lim Won Park TaeWook Kang Geum Ok Baek Moon Gyeong Yoon Ju A Son Ji HyangWeon Soon Sun Kim Hyo Jung Cho Jae Youn Cheong | 2023 | Cancer Communications2023，43，4： | 2 |
| 5 | Exosomes:a new delivery system for tumor antigens in cancer immunotherapy显示文摘 | CHO J A YEO D J SON H Y | 2005 | Int J Cancer2005，114，4： | 1 |
| 6 | Antibiotic resistance and plasmid profile of Aeromonas hydrophilia isolates from cultured fish 显示文摘 | Son R Rusul G Sahilah A M | 1997 | Letters of Applied Microbiology1997，，24： | 1 |
| 7 | Synthesis of a new hyperbranehed poly(silylenevinylene) with ethynyl functionalization显示文摘 | Xiao Yingxin Wong R A Son D Y | 2000 | Macro- molecules2000，33，20： | 1 |
| 8 | Impact of baemoglobin- variabiIity in haemodialysis patients receiving erythropoie- sis stimulating agents for the management of renal anaemi- a 显示文摘 | Mac dougall IC son P Roche A | 2005 | J Am Soc Nephrol2005，16，： | 1 |
| 9 | Carbon supported, Al doped-Li3V2(PO4)3 as a high rate cathode material for lithium-ion batteries显示文摘 | CHO A R SON J N ARAVINDAN V | 2012 | Journal of Materials Chemistry2012，22，14： | 1 |
| 10 | An approach to the dyeing of polyester fiber using indigo and its extended wash fastness properties 显示文摘 | SON Young A HONG Jin Pyo KIM Tae Kyung | 2004 | Dyes and Pigments2004，，61： | 1 |
| 11 | Chromosome and spindle configurations of human oocytes matured in vitro after cryopreservation of at the germinal vesicle stages显示文摘 | Park S E Lee K A Son W Y | 1997 | Fertil Steril1997，68，92： | 1 |
| 12 | Experimental basis of determining maximum coronary, myocardial, and collateral blood flow by pressure measurements for assessing functional stenosis severity before and after percutaneous transluminal coronary angioplasty 显示文摘 | PIJLS N H VAN SON J A KIRKEEIDE R L | 1993 | Circulation1993，87，： | 1 |
| 13 | Probability of successful defibrillation at multiples of the defibrillation energy requirernent in patients with an implantable defibrillator显示文摘 | Strickberger S A Daoud E G David son T | | 0，，： | 1 |
| 14 | Managing deadline miss ratio and sensor data freshness in real-time databases显示文摘 | Kang K D Son S H Stankovic J A | 2004 | IEEE Transaction on Knowledge and Data Engineering2004，16，10： | 1 |
| 15 | Aromatase expression in endometrosis显示文摘 | Noble L S Simp son ER Johns A | 1996 | Clin Endocrino Metab1996，81，1： | 1 |
| 16 | Microbial reduction of perchlorate with zero-valent iron显示文摘 | Son A Lee J Chiu P C | 2006 | Water Research2006，40，10： | 1 |
| 17 | Feedback control real -time scheduling: framework, modeling, and algorithms显示文摘 | C Lu J A Stankovica G Tao and S H Son | 2001 | Re- al- Time Systems Journal Special Issue on Control -Theoretical Approaches to Real - Time Computing2001，，1： | 1 |
| 18 | Dynamic immune cellaccumulation during flow-induced atherogenesis in mouse carotidartery:an expanded flow cytometry method显示文摘 | Alberts-Grill N Rezvan A Son DJ | 2012 | ArteriosclerThromb Vasc Biol2012，32，3： | 1 |
| 19 | Castor-oil-based waterborne polyurethane dispersions cured with an azifidine based cross linker 显示文摘 | Son D A Raghu M H | 2011 | Macromolecular Material and En~neering2011，296，2： | 1 |
| 20 | Glutamine supports pan- creatic cancer growth through a KRAS -regulated metabolic pathway 显示文摘 | Son J Lyssiotis C A Ying H | 2013 | Nature2013，496，7443： | 1 |
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