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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | The European Cancer Anaemia Survey (ECAS): A large, multinational, prospective survey defining the prevalence, incidence, and treatment of anaemia in cancer patients显示文摘 | Heinz Ludwig Simon Van Belle Peter Barrett-Lee Gunnar Birgeg?rd Carsten Bokemeyer Pere Gascón Paris Kosmidis Maciej Krzakowski Johan Nortier Patrizia Olmi Maurice Schneider Dirk Schrijvers | 2004 | European Journal of Cancer2004，，15： | 2 |
| 3 | Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford显示文摘BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)patients.AIM To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving remission.METHODS A retrospective review of Australian and Oxford,United Kingdom data for UC patients.Clinical response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were assessed.Cox regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing them.Safety outcomes were recorded.RESULTS Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were included.The clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo respectively.Anti-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 mo.CONCLUSION VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome. | Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara Mogilevski Peter De Cruz Graham Radford-Smith Emma Flanagan Sally Bell Soleiman Kashkooli Miles Sparrow Simon Ghaly Peter Bampton Elise Sawyer Susan Connor Quart-ul-ain Rizvi Jane M Andrews Gillian Mahy Paola Chivers Simon Travis Ian Craig Lawrance | 2020 | World Journal of Gastroenterology2020，26，30： | 2 |
| 4 | Early prediction of endocrine therapy effect in advanced breast cancer patients using ^99mTc-depreotide scintigraphy 显示文摘 | VAN DEN BOSSCHE B VAN BELLE S DE WINTER F | 2006 | J Nucl Med2006，47，11： | 1 |
| 5 | Randomised,phase Ⅱ trial comparing oral capecitabine (Xeloda) with paclitaxel in patients with metastatic/advanced breast cancer pretreated with anthracyclines显示文摘 | Talbot DC Moiseyenko V van Belle S | 2002 | Br J Cancer2002，86，： | 1 |
| 6 | Effect of percutaneous adenovirus-mediated Gax gene delivery to the arterial wall in double-injured atheromatous stented rabbit iliac arteries显示文摘 | Maillard L Van Belle E Rio F | 2000 | Gene Ther2000，7，16： | 1 |
| 7 | Effectiveness of managin suspected pulmonary embolism using an algorithm combining clinical probability,D-dimer testing,and computed tomography显示文摘 | van Belle A Büller HR Huisman MV | 2006 | JAMA2006，295，2： | 1 |
| 8 | Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State显示文摘 | Wenjun Guo Zuzana Keckesova Joana Liu Donaher Tsukasa Shibue Verena Tischler Ferenc Reinhardt Shalev Itzkovitz Aurelia Noske Ursina Zürrer-H?rdi George Bell Wai Leong Tam Sendurai A. Mani Alexander van Oudenaarden Robert A. Weinberg | 2012 | Cell2012，，5： | 1 |
| 9 | The European Cancer Anaemia Survey (ECAS):a large, multinational, prospective survey defining the prevalence, incidence, and treatment of anaemia in cancer patients 显示文摘 | Ludwig H van Belle S Barrett-Lee P | 2004 | Eur J Cancer2004，40，15： | 1 |
| 10 | Nature of coronary disease in patients with insulin resistance and its impact on revascularization strategies显示文摘 | VAN BELLE E BAUTERS C MCFADDEN E | 2005 | Coron Artery Dis2005，16，8： | 1 |
| 11 | Qualitative assessment of the progesterone receptor and HER2 improves the Nottingham Prognostic Index up to 5 years after breast cancer diagnosis显示文摘 | Van Belle V Van Calster B Brouckaert O | 2010 | J Clin Oncol2010，28，27： | 1 |
| 12 | A Bayesian approach to robust adaptive beamforming显示文摘 | Bell K L Ephraim Y Van Trees H L | 2000 | IEEE Trans Signal Processing2000，48，2： | 1 |
| 13 | The European Cancer Anaemia Survey (ECAS) : a large, multinational, prospective survey defining the prevalence, incidence, and treatment of anaemia in cancer patients显示文摘 | Ludwig H Van Belle S Barrett-Lee P | 2004 | EurJ Cancer2004，40，15： | 1 |
| 14 | Six-month angiographic outcome after successful repeat percutaneous intervention for in-stent restenosis 显示文摘 | Bonos JL van Belle E | 1998 | Circulation1998，97，4： | 1 |
| 15 | Combinatorial antibodies against human malignant melanoma 显示文摘 | van Belle P Eleder D | 1997 | Immunology1997，16，1： | 1 |
| 16 | Effects of coronary stenting on vessel patency and long-termclini- cal outcome after perculaneous coronary revascularization in diabetic patients显示文摘 | VAN BELLE E PERIE M BRAUNE D | 2002 | J Am (2oll Cardiol2002，40，： | 1 |
| 17 | STEMI and NSTEMI: are they so different? 1 year outcomes in acute myocardial infarction as defined by the ESC/ACC definition (the OPERA registry) 显示文摘 | G Montalescot J DallongeviLle E Van Belle | 2007 | Eur Heart J2007，，： | 1 |
| 18 | Nonparametric estimation of species richness 显示文摘 | Smith E P and Van Belle G | 1984 | Biometrics1984，40，： | 1 |
| 19 | Using Genetic Programming to Generate Protocol Adaptors for Interprocess Communication 显示文摘 | Wemer Van Belle Tom Mens Theo D'Hondt | 2003 | Lecture Notes in Computer Science2003，2606，： | 1 |
| 20 | Identification of the ga- lactose binding domain of the adeno-associated virus seretype 9 capsid显示文摘 | Bell CL Gurda BL Van Vliet K | 2012 | J Virol2012，86，13： | 1 |
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