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| 1 | 焦炭特性及其在高炉下部的变化过程显示文摘气化、石墨化和溶解是影响焦炭从高炉软熔带至炉缸间行为的三个主要过程。过去几年在一些专题项目中对这些过程进行了研究。简要叙述并讨论了这些过程的相互作用及其与焦炭特性的关系。对焦炭的气化反应进行了实验室测试研究,用以评价高炉条件下焦炭的特性。用高炉条件下的气化测试装置测试了几种焦炭试样,考查的质量指标包括反应性、结构变化和强度等。用实际尺寸的焦炭块对块状焦炭试样的高温行为进行了评估,将不同种类的焦炭试样加热到2 000℃,以鉴别其在高温下的行为。高温下焦炭将发生石墨化,对高温反应后的强度进行了评定,并作了显微观察,发现了一些现象和组织结构的变化。焦炭与液态渣铁相互作用的研究结果对焦炭在高炉下部的行为有了更好的理解。通过试验研究了焦炭抗液态铁水溶解的性能,对入炉前的焦炭和经高温反应的焦炭分别进行了试验。分析讨论了焦炭的抗气化、抗石墨化和抗铁水溶解性能与其结构、化学成分和强度的关系。 | B van der Velden C J Atkinson T Bakker J R H Stuurwold G J Tijhuis 徐万仁 | 2014 | 世界钢铁2014，，2： | 11 |
| 2 | High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array显示文摘Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted breeding.In tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental cross.In rose breeding,crosses with unintended parents occur regularly.We developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one parent.One of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal parent.The densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 cM.Synteny with the strawberry(Fragaria vesca)genome was extensive.Rose ICM1 corresponded to F.vesca pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to Fv5.Rose ICM2 corresponded to parts of F.vesca pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6. | Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus J M Smulders | 2016 | Horticulture Research2016，3，1： | 6 |
| 3 | TAT-Gap19通过抑制啮齿动物星形胶质细胞的连接蛋白43半通道发挥抗惊厥作用显示文摘越来越多的证据表明,星形胶质细胞连接蛋白43(Cx43)信号在癫痫中发挥至关重要的作用。但是,由于通过实验方法鉴别Cx43间隙连接通道(GJCs)和半通道(HCs)的技术尚不成熟,导致目前尚无法确定哪个通道在癫痫的发生中发挥更重要的作用。因此,本研究观察TAT-Gap19(Cx模拟肽)是否通过抑制Cx43半通道而非Cx43间隙连接通道影响实验诱导的啮齿动物癫痫发作。急性海马切片小鼠染料摄取实验表明,星形胶质Cx43半通道响应化学惊厥毛果芸香碱的作用而开放,并且可被TAT-Gap19抑制。体内实验中,毛果芸香碱诱导的癫痫发作及相伴随的D-丝氨酸微透析液的增长水平被Cx43半通道的抑制所抑制。此外,TAT-Gap19的抗惊厥作用被外源性D-丝氨酸给药逆转,这表明,抑制Cx43半通道可以通过降低细胞外D-丝氨酸水平来防止癫痫发作。抑制Cx43半通道的抗惊厥特性在电癫痫小鼠模型(如急性6 Hz难治性癫痫发作模型和慢性6 Hz角膜点燃模型)中得到了进一步的证实。总而言之,这些结果表明,Cx43半通道在癫痫发作中可以起到一定作用,并且有成为癫痫治疗中新型用药靶点的潜力。 | Walrave L Pierre A Albertini G Aourz N De Bundel D Van Eeckhaut A Vinken M Giaume C Leybaert L Smolders I 聂昊 | 2018 | 神经损伤与功能重建2018，13，6： | 5 |
| 4 | Antioxidant enriched enteral nutrition and oxidative stress after major gastrointestinal tract surgery显示文摘AIM: To investigate the effects of an enteral supple-ment containing antioxidants on circulating levels of antioxidants and indicators of oxidative stress after major gastrointestinal surgery.METHODS: Twenty-one patients undergoing major upper gastrointestinal tract surgery were randomised in a single centre, open label study on the effect of postoperative enteral nutrition supplementedwith antioxidants. The effect on circulating levels of antioxidants and indicators of oxidative stress, such as F2-isoprostane, was studied. RESULTS: The antioxidant enteral supplement showed no adverse effects and was well tolerated. After surgery a decrease in the circulating levels of antioxidant parameters was observed. Only selenium and glutamine levels were restored to pre-operative values one week after surgery. F2-isoprostane increased in the first three postoperative days only in the antioxidant supplemented group. Lipopolysaccharide binding protein (LBP) levels decreased faster in the antioxidant group after surgery.CONCLUSION: Despite lower antioxidant levels there was no increase in the circulating markers of oxidative stress on the first day after major abdominal surgery. The rise in F2-isoprostane in patients receiving the antioxidant supplement may be related to the conversion of antioxidants to oxidants which raises questions on antioxidant supplementation. Module AOX restored the postoperative decrease in selenium levels. The rapid decrease in LBP levels in the antioxidant group suggests a possible protective effect on gut wall integrity. Further studies are needed on the role of oxidative stress on outcome and the use of antioxidants in patients undergoing major abdominal surgery. | Mireille FM van Stijn Gerdien C Ligthart-Melis Petra G Boelens Peter G Scheffer Tom Teerlink Jos WR Twisk Alexander PJ Houdijk Paul AM van Leeuwen | 2008 | World Journal of Gastroenterology2008，14，45： | 4 |
| 5 | Phosphorus removal from wastewater by anaerobic-anoxic sequencing batch reactor显示文摘 | Kuba T Van Loosdrecht M C M Smolders G | 1993 | War Sci Tech1993，27，56： | 2 |
| 6 | Growth hormone modulation of the rat hepatic bile transporter system in endotoxin-induced cholestasis显示文摘 | Mesotten D Van den Berghe G Liddle C | 2003 | Endocrinology2003，144，9： | 2 |
| 7 | The dissolution of Na2O-MgO-CaO-SiO2 glass in aqueous HF solutions 显示文摘 | SPIERINGS G A C M van DIJK J | 1987 | J Mater Sci1987，22，： | 2 |
| 8 | Incorporated sarcolemmal fish oil fatty acids shorten pig ventricular action potentials 显示文摘 | VERKERK A O VAN GINNEKEN A C BERECKI G | 2006 | Cardiovasc Res2006，70，3： | 1 |
| 9 | Comparison of fluticasone propionate aqueous nasal spray and oral montelukast for the treatment of seasonal allergic rhinitis symptoms显示文摘 | MARTIN B G ANDREWS C P VAN BAVEL J H | 2006 | Ann Allergy Asthma Immunol2006，96，： | 1 |
| 10 | Regio- and stereospecificity in propene polymerization with MgCl2- supported Ziegler-Natta catalysts: Effects of hydrogen and the external donor显示文摘 | Chadwick J C van Kessel G M M Sudmeijer O | 1995 | Macromol Chem Phys1995，196，5： | 1 |
| 11 | Medical Innovation Revisited:Social Contagion Versus Marketing Effort显示文摘 | LILIEN G | 2001 | American Journal of Sociology2001，106，5： | 1 |
| 12 | The coexistence of geopolymeric gel and calcium silicate hydrate at the early stage of alkaline activation显示文摘 | Yip C K Lukey G C van Deventer J S J | 2005 | Cem Concr Res2005，35，9： | 1 |
| 13 | Dendritic Cells as a tool to induce transplantation tolerance:Obstacles and Opportunities显示文摘 | Van Kooten C Lombardi G Geldennan K A | 2010 | Transplantation2010，，： | 1 |
| 14 | Postprandial blood hormone and metabolite concentrations influenced by feeding frequency and feeding level in veal calves显示文摘 | VICARI T VAN DEN BORNE J J G C GERRITS W J J | 2008 | Domestic Animal Endocrinology2008，34，： | 1 |
| 15 | Biodiversity assessment using markers for ecologically important traits显示文摘 | Van TIENDEREN P H De HAAN A A Van der LINDEN C G | 2002 | Trends Ecol Evol2002，17，： | 1 |
| 16 | Dynamic turboFLASH subtraction technique for contrast-enhanced MR imaging of the prostate:correlation with histopathologic results显示文摘 | Jager G J Ruijter E T G Van de Kaa C A | 1997 | Radiology1997，203，： | 1 |
| 17 | Balance control in patients with distal versus proximal muscle weakness显示文摘 | HORLINGS C G KUNG U M VAN ENGELEN B G | 2009 | Neuroscience2009，164，4： | 1 |
| 18 | Changes in volatile production during an infection of potatoes by Erwinia carotovora显示文摘 | LYEW D Y VAN GARIEPY G S V RAGHAVAN A C | 2001 | Food Research International2001，34，： | 1 |
| 19 | Zinc sulphate-induced anosmia decreases the nerve fibre density in the anterior cerebral artery of the rat显示文摘 | VAN DENDEREN J C VAN WIERINGEN G W HILLEN B | 2001 | Auton Neurosci2001，94，： | 1 |
| 20 | The murine homologue of HIRA,a DiGeorge syndrome candidate gene,is expressed in embryonic structures affected in human CATCH22 patients显示文摘 | Wilming L G Snoeren C A van Rijswijk A | 1997 | Hum Mol Genet1997，6，2： | 1 |
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