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| 1 | Proteomics for discovery of candidate colorectal cancer biomarkers显示文摘Colorectal cancer(CRC)is the second most common cause of cancer-related deaths in Europe and other Western countries,mainly due to the lack of wellvalidated clinically useful biomarkers with enough sensitivity and specificity to detect this disease at early stages.Although it is well known that the pathogenesis of CRC is a progressive accumulation of mutations in multiple genes,much less is known at the proteome level.Therefore,in the last years many proteomic studies have been conducted to find new candidate protein biomarkers for diagnosis,prognosis and as therapeutic targets for this malignancy,as well as to elucidate the molecular mechanisms of colorectal carcinogenesis.An important advantage of the proteomic approaches is the capacity to look for multiple differentially expressed proteins in a single study.This review provides an overview of the recent reports describing the different proteomic tools used for the discovery of new protein markers for CRC such as two-dimensional electrophoresis methods,quantitative mass spectrometry-based techniques or protein microarrays.Additionally,we will also focus on the diverse biological samples used for CRC biomarker discovery such as tissue,serum and faeces,besides cell lines and murine models,discussing their advantages and disadvantages,and summarize the most frequently identified candidate CRC markers. | Paula lvarez-Chaver Olalla Otero-Estévez María Páez de la Cadena Francisco J Rodríguez-Berrocal Vicenta S Martínez-Zorzano | 2014 | World Journal of Gastroenterology2014，20，14： | 7 |
| 2 | Mercury removal using ground and calcined mussel shell显示文摘We determined mercury retention on calcined and ground mussel shell, in presence and absence of phosphate, using batch and stirred flow chamber experiments. In batch experiments the calcined shell exhibited higher Hg adsorption, with good fitting to Freundlich equation(R2: 0.925–0.978); the presence of phosphate increased Hg adsorption; mercury desorption was 13% or lower, diminishing up to 2% under the presence of phosphates. In stirred flow chamber experiments calcined shell retained more Hg than ground shells(6300 vs. 4000–5200 μmol/kg); Hg retention increased an additional 40% on calcined shell and up to an additional 70% on ground shells when phosphates were present; mercury desorption was quite similar in all shell types(20%–34%), increasing up to 49%–60% in ground shells when phosphates were present. The higher Hg adsorption on calcined shell would be related to its calcite and dolomite concentrations; mercury-phosphate interactions would cause the increase in Hg retention when phosphates are present. Data on Hg desorption suggest that Hg retention was not easily reversible after batch experiments, increasing in the stirred flow chamber due to convective flow. Calcined and ground mussel shells could be recycled removing Hg from water, with the presence of phosphates in solution improving efcacy. | Susana Pea-Rodríguez Alipio Bermúdez-Couso Juan Carlos Nóvoa-Muoz Manuel Arias-Estvez María J.Fernndez-Sanjurjo Esperanza lvarez-Rodríguez Avelino Núez-Delgado | 2013 | Journal of Environmental Sciences2013，25，12： | 3 |
| 3 | Effect of femtosecond laser-assisted lens surgery on the optic nerve head and the macula显示文摘AIM: To evaluate the effect of femtosecond laser-assisted lens surgery(FLALS;cataract surgery or refractive lens exchange) on the structure of the optic nerve head and the macula.METHODS: This prospective longitudinal study included healthy eyes undergoing FLALS. Eyes with glaucoma or any other ocular disease that could alter optical coherence tomography results were excluded. Retinal nerve fiber layer(RNFL), Bruch’s membrane opening-minimum rim width(BMO-MRW) and macular thickness(MT) were measured preoperatively, 1 and 6 mo after surgery using spectral-domain optical coherence tomography(SD-OCT). Changes between preoperative and postoperative values were evaluated.RESULTS: A total of 87 eyes of 46 patients were included in this study. Preoperative RNFL, BMO-MRW and MT in microns(μm) were 100.77±10.39, 330.31±49.99 and 276.30±33.39, respectively. Postoperative RNFL, BMO-MRW and MT were 104.74±11.55, 348.32±54.05 and 279.83±22.65 1 mo after surgery and 102.93±11.17, 343.11±53.4 and 278.90±22.19 6 mo after surgery, respectively;which equals an increase of 3.93%, 5.45% and 1.27%,respectively, 1 mo after surgery, and 2.14%, 3.87% and 0.94% 6 mo after surgery. The differences between the preoperative and the postoperative RNFL and BMO-MRW values were statistically significant(P<0.001). Regarding MT values, there were not statistically significant differences(P=0.26).CONCLUSION: Our study suggests that FLALS does not have a negative impact on the structural status of the optic nerve head in healthy eyes, assessed by SD-OCT. There is a slight increase in the values of RNFL, BMO-MRW and MT 1 mo and 6 mo after surgery. | Josefina Renones de Abajo Beatriz Estévez Jorge Jesús María González Martín Humberto Carreras Díaz Juan Francisco Loro Ferrer Alfonso Antón López | 2019 | International Journal of Ophthalmology(English edition)2019，12，6： | 2 |
| 4 | Structural analysis of nanocrystalline BaTiO3显示文摘 | CHA VEZ E FUENTES S ZARATE R A | 2010 | Journal of Molecular Structure2010，984，123： | 1 |
| 5 | 显示文摘 | CORT(E)S-J(A)COME M A ESCOBAR J ANGELES CH(A)VEZ C LPEZ-SALINAS E ROMERO E FERRAT G TOLEDO-ANTONIO J A | 2008 | Catal Today2008，130，1： | 1 |
| 6 | In vitro activity of voriconazole,itraconazole,caspofungin,anidulafungin (VER002,LY303366) and amphotericin B against aspergillus spp显示文摘 | Serrano Mdel C Valverde-Conde A Chávez M M | | 0，，02： | 1 |
| 7 | GrowthI survival, lipid composition and pigmentation of turbot(Scophthalmus maximus) larvae fed live-prey enriched in arachidonic and eicosapentaenoic acids显示文摘 | Estévez A McEvoy L A Bell J G | 1999 | Aquaculture1999，180，： | 1 |
| 8 | A study of the urban heat island of Granada显示文摘 | Mont vez J P Rodr guez A Jim nez J I | 2000 | International Journal of Climatology2000，20，： | 1 |
| 9 | Highly dispersed CoMoS phase on titania nanotubes as efficient HDS显示文摘 | Cortés-Jácome M A Escobar J Angeles Chávez C | 2008 | Catalysts Catalysis Today2008，130，1： | 1 |
| 10 | Behavioral and neurotoxicological effects of subchronic manganese exposure in rats显示文摘 | Vez wr T Papp A Hoyk Z | 2005 | Environ Toxicol Pharmacol2005，19，3： | 1 |
| 11 | Retroperitoneal epithelioid sarcoma: A case report显示文摘Epithelioid sarcoma(ES), a mesenchymatous malign neoformation, is often diagnosed in later stages and associated with high recurrence index, metastasis and mortality. We report a case of a 65 years old male, with history of abdominal pain and upper gastrointestinal bleeding. Endoscopy demonstrated a posterior duodenal wall perforation communicating with a solid retroperitoneal neoformation. Endoscopic biopsy was performed, with a final report of ES. The patient was submitted for surgical palliation due to the tumor's unresectability. Retroperitoneal ES is an extremely rare condition with limited reports in the literature where guidelines for its optimal treatment are not well established. | JoséA Coronado MigueláChávez Martín A Manrique Jony Cerna Ana L Trejo | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，12： | 1 |
| 12 | In-vitro activity of voriconazole (UK-109,496),LY303366 and other antifungal agents against oral candida spp显示文摘 | Chávez M Bernal S Valverde A | 1998 | Journal of Antimicrobial Chemotherapy1998，42，1： | 1 |
| 13 | Fast neurotransmitter release triggered by Ca influx through AMPA-type glutamate receptors显示文摘 | Chávez A E Singer J H Diamond J S | | 0，，7112： | 1 |
| 14 | Fibre concentrates from apple pomace and citrus peel as potential fibre sources for food enrichment显示文摘 | Fernando Figuerola María Luz Hurtado Ana María Estévez | 2005 | Food Chemistry2005，91，3： | 1 |
| 15 | Environmental geochemistry of the Guanajuato Mining District, Mexico 显示文摘 | Carrillo-Ch vez A Morton-Bermea O Gonz lez-Partida E | 2003 | Ore Geol Rev2003，23，： | 1 |
| 16 | 1-Deoxy-D-xylulose-5-phosphate synthase, a limiting enzyme for plastidie isoprenoid biosynthesis in plants显示文摘 | Est Vez J M Cantero A Reindl A | 2001 | Journal of Biological Chemistry2001，276，22： | 1 |
| 17 | Modeling of total soluble solid and NaCl uptake during osmotic treatment of bell peppers under different infusion pressures显示文摘 | Quintero Chávez R Quintero Ramos A Jiménez Castro J | 2012 | Food and Bioprocess Technology2012，5，1： | 1 |
| 18 | An analysis of the effect of the footprint orientation on the thermal hydraulic performance of a microchannels heat sink during flow boiling of R245fa 显示文摘 | LEO H L S L CHVEZ C A DO NASCIMENTO F J | 2015 | Applied Thermal Engineering2015，90，： | 1 |
| 19 | Pharmacokinetics of prednisolone in man during acute and chronic exposure to high altitude显示文摘 | Arancibia A Gai MN Chávez J | 2005 | Int J Clin Pharm Ther2005，43，2： | 1 |
| 20 | The role of glomalin,a protein produced by arbuscular mycorrhizal fungi,in sequestering potentially toxic elements显示文摘 | GONZ(A)LEZ-CH(A)VEZ M C CARRILLO-GONZ(A)LEZ R WRIGHT S F | 2004 | Environmental Pollution2004，130，3： | 1 |
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