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| 1 | Oral purgative and simethicone before small bowel capsule endoscopy显示文摘AIM:To evaluate small bowel cleansing quality,diagnostic yield and transit time,comparing three cleansing protocols prior to capsule endoscopy.METHODS:Sixty patients were prospectively enrolled and randomized to one of the following cleansing protocols:patients in Group A underwent a 24 h liquid diet and overnight fasting;patients in Group B followed protocol A and subsequently were administered 2 L of polyethylene glycol(PEG) the evening before the procedure;patients in Group C followed protocol B and were additionally administered 100 mg of simethicone 30 min prior to capsule ingestion.Small bowel cleansing was independently assessed by two experienced endoscopists and classified as poor,fair,good or excellent according to the proportion of small bowel mucosa under perfect conditions for visualization.When there was no agreement between the two endoscopists,the images were reviewed and discussed until a consensus was reached.The preparation was considered acceptable if > 50% or adequate if > 75% of the mucosa was in perfect cleansing condition.The amount of bubbles was assessed independently and it was considered significant if it prevented a correct interpretation of the images.Positive endoscopic findings,gastric emptying time(GET) and small bowel transit time(SBTT) were recorded for each examination.RESULTS:There was a trend favoring Group B in achieving an acceptable(including fair,good or excellent) level of cleansing(Group A:65%;Group B:83.3%;Group C:68.4%) [P = not significant(NS)] and favoring Group C in attaining an excellent level of cleansing(Group A:10%;Group B:16.7%;Group C:21.1%)(P = NS).The number of patients with an adequate cleansing of the small bowel,corresponding to an excellent or good classification,was 5(25%) in Group A,5(27.8%) in Group B and 4(21.1%) in Group C(P = 0.892).Conversely,7 patients(35%) in Group A,3 patients(16.7%) in Group B and 6 patients(31.6%) in Group C were considered to have poor small bowel cleansing(P = 0.417),with significant fluid or debris such that the examination was unreliable.The proportion of patients with a significant amount of bubbles was 50% in Group A,27.8% in Group B and 15.8% in Group C(P = 0.065).This was significantly lower in Group C when compared to Group A(P = 0.026).The mean GET was 27.8 min for Group A,27.2 min for Group B and 40.7 min for Group C(P = 0.381).The mean SBTT was 256.4 min for Group A,256.1 min for Group B and 258.1 min for Group C(P = 0.998).Regarding to the rate of complete examinations,the capsule reached the cecum in 20 patients(100%) in Group A,16 patients(88.9%) in Group B and 17 patients(89.5%) in Group C(P = 0.312).A definite diagnosis based on relevant small bowel endoscopic lesions was established in 60% of the patients in Group A(12 patients),44.4% in Group B(8 patients) and 57.8% in Group C(11 patients)(P = 0.587).CONCLUSION:Preparation with 2 L of PEG before small bowel capsule endoscopy(SBCE) may improve small bowel cleansing and the quality of visualization.Simethicone may further reduce intraluminal bubbles.No significant differences were found regarding GET,SBTT and the proportion of complete exploration or diagnostic yield among the three different cleansing protocols. | Bruno Joel Ferreira Rosa Mara Barbosa Joana Magalhes Ana Rebelo Maria Joo Moreira José Cotter | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，2： | 21 |
| 2 | 莫沙必利在老年人胶囊内镜检查中的作用显示文摘目的探讨应用莫沙必利对老年患者胶囊内镜检查中胃肠转运时间的影响。方法2010年9月至2012年1月间因疑似小肠疾病的患者61例,其中年龄≥65岁者40例,随机分为老年服药组19例和老年对照组21例,年龄〈65岁者21例为非老年对照组。服药组胶囊内镜检查前口服促胃肠动力药莫沙比利10mg,记录胶囊内镜的胃肠通过时间。结果老年服药组胃及小肠通过时间分别为(48.6±21.1)min和(302.2±67.6)min,老年对照组分别为(64.3±22.4)min和(347.1±51.2)min,两组差异有统计学意义(t胃=2.274,P胃=0.029;t肠=2.384,P肠=0.022)。非老年对照组胃及小肠通过时间分别为(45.4±28.4)min和(284.8±78.3)min,与老年服药组比较,差异无统计学意义(t胃=0.407,P胃=0.686;t肠=0.751,P肠=0.457)。老年服药组和老年对照组图像评分分别为(4.94±0.63)分和(4.50±0.68)分,差异有统计学意义(t=2.137,P=0.039)。结论老年患者胶囊内镜检查前口服莫沙必利药能缩短胶囊胃肠通过时间,改善胶囊镜的图像质量,提高检查完成率。 | 张颖 齐凤祥 张志广 | 2013 | 中华老年医学杂志2013，32，3： | 6 |
| 3 | 胶囊内镜对不明原因消化道出血的阳性预测因素分析显示文摘目的分析胶囊内镜(caspule endoscopy, CE)对不明原因消化道出血(obscure gastrointestinal bleeding, OGIB)的阳性预测因素。方法选取成都市第三人民医院2014年6月至2018年2月因OGIB接受CE检查的104例患者作为研究对象,回顾性分析OGIB患者的性别、年龄、出血量分级、贫血程度、肠道清洁度、检查时机等临床指标与CE诊断率的关系。结果 CE检查对OGIB的诊断检出率为79.8%,诊断率为39.4%,阴性率为20.2%。单因素分析显示,最后诊断为P_2、P_1、P_0病变的三组病例中,出血量分级、出血距CE检查时间、胃通过时间、肠道清洁度评分和小肠通过时间等差异有统计学意义(P<0.05)。多元有序Logistic回归分析显示,出血距检查时间短(β=-0.294,OR=0.745,95%CI:0.635~0.874,P<0.001)和出血量大(β=1.239,OR=3.452,95%CI:1.387~8.593,P<0.008)是CE检查阳性的预测因素,充分的肠道清洁准备能提高CE的阳性诊断率。结论 CE对于OGIB是一种有效的检查手段,选择出血量较大的病例和早期行CE检查对提高诊断阳性率有较大影响。 | 袁德强 史维 孙晓滨 胡玲 杨梅 李姣 冉文斌 | 2019 | 胃肠病学和肝病学杂志2019，28，4： | 6 |
| 4 | 莫沙必利对胶囊内镜检查质量的影响显示文摘[目的]探讨莫沙必利对胶囊内镜检查质量的影响。[方法]将55例进行胶囊内镜检查的患者随机分为研究组(27例)和对照组(28例)。研究组检查前晚和服用胶囊内镜前30min各口服莫沙必利5mg,对照组则不服任何药物。观察2组患者在肠道准备中有无恶心、呕吐、腹痛等不良反应,记录2组患者胶囊内镜在胃内和小肠的运行时间、排出体内时间和图像评分并进行比较。[结果]研究组在肠道准备过程中不良反应发生率、胶囊内镜胃内运行时间明显低于对照组(P<0.05),图像评分明显高于对照组(P<0.05);2组胶囊内镜小肠内运行时间比较差异无统计学意义(P>0.05)。[结论]莫沙必利能明显减少胶囊内镜检查肠道准备过程中的不良反应和胶囊内镜胃排空时间,提高肠道清洁度及图像质量,安全性高。 | 陈红莉 唐建光 苏艺群 陈璇 蒋瑜 阳建林 段杨丽 | 2017 | 临床消化病杂志2017，29，5： | 5 |
| 5 | 肠道注气在胶囊内镜检查小肠疾病中的作用显示文摘目的探讨在肠道注气状态下胶囊内镜的小肠黏膜观察效果,以期进一步提高小肠疾病的检出率。方法2011年11月至2012年4月,将解放军总医院消化科行胶囊内镜检查患者,采用随机数字表法分为注气干预组(n=14)和常规检查组(n=13),对比分析全小肠检查完成率和阳性发现率、胶囊内镜在小肠的转运时间、小肠清洁程度和展开程度。结果注气干预组与常规检查组在全小肠检查完成率[85.71%(12/14)比61.54%(8/13),P=0.209]和疾病阳性发现率[71.43%(10/14)比84.62%(11/13),P〉O.05]方面,差异均无统计学意义。注气干预组的小肠通过时间为(270.86±144.85)min,较常规检查组的(325.15±161.76)min有所缩短,但差异无统计学意义(P=0.369)。注气干预组整体肠道清洁程度好于常规检查组[(2.05±0.40)分比(1.75±0.40)分],差异亦无统计学意义(P=0.060)。注气干预组整体肠腔展开程度明显好于常规检查组[(1.79±0.40)分比(1.38±0.29)分],差异有统计学意义(P=0.004)。结论注气干预胶囊内镜检查,可以显著提高小肠黏膜展开程度,并有提升小肠整体清洁度及缩短全小肠工作时间的趋势。 | 史以超 蔡顺天 李中原 孙刚 彭丽华 杨云生 | 2018 | 中华消化内镜杂志2018，35，4： | 2 |
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