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| 1 | 肠镜前肠道准备方法研究近况显示文摘肠镜检查是肠道黏膜病变的一项重要诊断方法 ,肠道准备的优劣直接影响了检查的结果甚至镜下治疗的成败。临床试验常在甘露醇、硫酸镁、复方聚乙二醇电解质散、磷酸钠口服溶液、人工灌肠、仪器灌肠等常用泻药或通便疗法的浓度、用药时机、经济性、适用人群中进行对比研究,不同国家及区域的研究结果不尽相同。同时针对长期便秘的人群来说,如何提前做好准备,更有效地给予药物及饮食干预,缩短便秘患者的肠道准备时间,提高肠道准备清洁度,且不增加不良反应,是临床研究的难点及热点。 | 许珊珊 黎军 | 2014 | 医学综述2014，20，21： | 6 |
| 2 | A population-based case-crossover study of polyethylene glycol use and acute renal failure risk in the elderly显示文摘AIM:To evaluate the possibility of an association between polyethylene glycol(PEG) and acute renal failure(ARF) in elderly patients using a health insurance claims database.METHODS:We conducted a population-based casecrossover study using information obtained from Korean Health Insurance Review and Assessment Service(HIRA) claims from January 1,2005 to December 31,2005(Seoul,Korea).The study population consisted of elderly patients who received PEG prior to experiencing their first ARF-related hospitalization from April 1,2005 to December 31,2005.For each patient,one case and two control periods were matched.PEG use in a 2-or 4-wk window period prior to hospitalization for ARF was compared with PEG use in two earlier 2-or 4-wk control window periods.Conditional logistic regression analysis was used to estimate odds ratios(ORs) and 95% CI,adjusting for concomitant uses of diuretics,angiotensin converting enzyme inhibitors,non-steroidal anti-inflammatory drugs,antibiotics,anti-cancer drugs,and contrast media.RESULTS:Within the HIRA database which contained 1 093 262 elderly patients,1156 hospitalized ARF cases were identified.Among these cases,PEG was prescribed to 17(1.5%) patients before hospitalization.The adjusted ORs when applying the 2-and 4-wk window periods were 0.4(95% CI:0.03-5.24) and 2.1(95% CI:0.16-27.78),respectively.CONCLUSION:No increased risk of ARF was found in elderly PEG users.However,based on the limited number of study subjects,further analysis should be performed to confirm these results. | Nam-Kyong Choi Yoosoo Chang Sun-Young Jung Yu-Kyong Choi Joongyub Lee Jin-Ho Lee Ju-Young Kim Byung-Joo Park | 2011 | World Journal of Gastroenterology2011，17，5： | 0 |
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