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| 1 | 中国非酒精性脂肪性肝病诊疗指南(2010年修订版)显示文摘非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)是一种与胰岛素抵抗(insulin resistance,IR)和遗传易感密切相关的代谢应激性肝脏损伤,其病理学改变与酒精性肝病(alcoholic liver disease,ALD)相似,但患者无过量饮酒史,疾病谱包括非酒精性单纯性脂肪肝(nonalcoholic simple fatty liver,NAFL)、非酒精性脂肪性肝炎(nonalcoholic steatohepatitis,NASH)及其相关肝硬化和肝细胞癌[1,2],NAFLD 是21世纪全球重要的公共健康问题之一,亦是我国愈来愈重视的慢性肝病问题[3]。 | 范建高 | 2012 | 中国医学前沿杂志(电子版)2012，4，7： | 270 |
| 2 | 非酒精性脂肪性肝病诊疗指南显示文摘非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)是一种与胰岛素抵抗(insulin resistance,IR)和遗传易感密切相关的代谢应激性肝脏损伤。 | 中华医学会肝脏病学分会脂肪肝和酒精性肝病学组 | 2010 | 中国肝脏病杂志(电子版)2010，2，4： | 468 |
| 3 | 非酒精性脂肪性肝病诊疗指南显示文摘非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)是一种与胰岛素抵抗(insulin resistance,IR)和遗传易感密切相关的代谢应激性肝脏损伤,其病理学改变与酒精性肝病(alcoholic liver disease,ALD)相似,但患者无过量饮酒史,疾病谱包括非酒精性单纯性脂肪肝(nonalcoholic simple fatty liver,NAFL)、非酒精性脂肪性肝炎(nonalcoholic steatohepatitis,NASH)及其相关肝硬化和肝细胞癌[1-2]. | 中华医学会肝脏病学分会脂肪肝和酒精性肝病学组 | 2010 | 中华糖尿病杂志2010，2，1： | 501 |
| 4 | 非酒精性脂肪性肝病诊疗指南(2010年1月修订)显示文摘非酒精性脂肪性肝病(nonalcoholicfattyliverdisease,NAFLD)是一种与胰岛素抵抗(insulinresistance,IR)和遗传易感密切相关的代谢应激性肝脏损伤,其病理学改变与酒精性肝病(alcoholicliverdisease,ALD)相似,但患者无过量饮酒史,疾病谱包括非酒精性单纯性脂肪肝(nonalcoholicsimplefattyliver,NAFL)、非酒精性脂肪性肝炎(nonalcoholicsteatohepatitis,NASH)及其相关肝硬化和肝细胞癌。 | | 2010 | 中华内科杂志2010，49，3： | 138 |
| 5 | 非酒精性脂肪性肝病诊疗指南(2010年修订版)显示文摘非酒精性脂肪性肝病(NAFLD)是一种与胰岛素抵抗(insulin resistance,IR)和遗传易感密切相关的代谢应激性肝脏损伤,其病理学改变与酒精性肝病(ALD)相似,但患者无过量饮酒史,疾病谱包括非酒精性单纯性脂肪肝(nonalcoholic simple fatty liver,NAFL)、非酒精性脂肪性肝炎(NASH)及其相关肝硬化和肝细胞癌。 | | 2010 | 中华肝脏病杂志2010，18，3： | 1149 |
| 6 | 非酒精性脂肪性肝病诊疗指南显示文摘 | 范建高 | 2010 | 临床肝胆病杂志2010，26，2： | 136 |
| 7 | 非酒精性脂肪性肝病诊疗指南(2010年修订版)显示文摘 | 范建高 | 2010 | 胃肠病学和肝病学杂志2010，19，6： | 410 |
| 8 | 非酒精性脂肪性肝病诊疗指南(2010年修订版)显示文摘非酒精性脂肪性肝病(NAFLD)是一种与胰岛素抵抗(IR)和遗传易感密切相关的代谢应激性肝脏损伤,其病理学改变与酒精性肝病(ALD)相似,但患者无过量饮酒史,疾病谱包括非酒精性单纯性脂肪肝(NAFL)、非酒精性脂肪性肝炎(NASH)及其相关肝硬化和肝细胞癌[1-2]。NAFLD是21世纪全球重要的公共健康问题之一,亦是我国愈来愈重要的慢性肝病问题[3]。为进一步规范NAFLD的诊断和治疗。 | 范建高 | 2011 | 现代医药卫生2011，27，5： | 120 |
| 9 | 非酒精性脂肪性肝病诊疗指南显示文摘非酒精性脂肪性肝病(non-alcoholic fatty liver disease。NAFLD)是一种与胰岛素抵抗(IR)和遗传易感性密切相关的代谢应激性肝损伤.病理学改变与酒精性肝病(ALD)相似.但患者无过量饮酒史,疾病谱包括非酒精性单纯性脂肪肝(non-alcoholic simple fatty liver,NAFL)、非酒精性脂肪性肝炎(non-alcoholic steatohepatitis,NASH)及其相关肝硬化和肝细胞性肝癌。 | 范建高 | 2010 | 胃肠病学2010，15，11： | 59 |
| 10 | Relationship between alanine aminotransferase levels and metabolic syndrome in nonalcoholic fatty liver disease显示文摘Objective:To investigate the relationship between alanine aminotransferase (ALT) levels and metabolic syndrome (MS) in nonalcoholic fatty liver disease (NAFLD). Methods: A total of 26527 subjects who received medical health checkup in our hospital from January 2005 to July 2007 were enrolled in the study. The diagnosis of fatty liver was based on ultrasound imaging. MS was defined according to the criteria of the Adult Treatment Panel III. ALT, triglyceride (TG), high density lipo-protein cholesterol (HDL-c), fasting plasma glucose (FPG), height, weight, waist circumference (WC), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured in each subject to analyze the relationship between MS and ALT activity. Results: (1) The prevalence of NAFLD in men (30.94%) was significantly higher than that in women (15.65%); (2) The incidence of MS in NAFLD (33.83%) was significantly greater than that in non-NAFLD (10.62%); (3) Of the 6470 subjects with NAFLD, in the age-adjusted partial correlation analysis, there were statistically significant correlations between the ALT levels and most metabolic risk factors in each sex (P<0.01), except that ALT levels had no correlation with HDL-c in women. Moreover, in the multiple stepwise regression analysis, SBP lost its significance, and WC, body mass index (BMI), age, DBP, TG and FPG were independently associated with ALT levels in both sexes (P<0.05). HDL-c remained significant and was independently related to ALT levels in men; (4) ALT levels were significantly higher in subjects with MS compared to those without MS (P<0.001). Mean ALT levels increased with the number of MS components in each sex (P<0.05 for trend). Conclusion: We found a strong rela-tionship between ALT levels and MS in NAFLD and revealed that the cluster of MS components might be the predictor for ALT elevations. | Zhou-wen CHEN Li-ying CHEN Hong-lei DAI Jian-hua CHEN Li-zheng FANG | 2008 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008，9，8： | 45 |
| 11 | Non-alcoholic fatty liver disease in 2015显示文摘There is worldwide epidemic of non-alcoholic fatty liver disease(NAFLD). NAFLD is a clinical entity related to metabolic syndrome. Majority of the patients are obese but the disease can affect non-obese individuals as well. Metabolic factors and genetics play important roles in the pathogenesis of this disorder. The spectrum of disorders included in NAFLD are benign macrovesicular hepatic steatosis, non-alcoholic steatohepatitis, hepatic fibrosis, cirrhosis of liver and hepatocellular carcinoma. Although the disease remains asymptomatic most of the time, it can slowly progress to end stage liver disease. It will be the most common indication of liver transplantation in the future. It is diagnosed by abnormal liver chemistry, imaging studies and liver biopsy. As there are risks of potential complications during liver biopsy, many patients do not opt for liver biopsy. There are some noninvasive scoring systems to find out whether patients have advanced hepatic fibrosis. At the present time, there are limited treatment options which include lifestyle modification to loose weight, vitamin E and thioglitazones. Different therapeutic agents are being investigated for optimal management of this entity. There are some studies done on incretin based therapies in patients with NAFLD. Other potential agents will be silent information regulator protein Sirtuin and antifibrotic monoclonal antibody Simtuzumab against lysyl oxidase like molecule 2. But they are still in the investigational phase. | Monjur Ahmed | 2015 | World Journal of Hepatology2015，7，11： | 41 |
| 12 | What about non-alcoholic fatty liver disease as a new criterion to define metabolic syndrome?显示文摘Non-alcoholic fatty liver disease (NAFLD) is currently not a component of the diagnostic criteria for metabolic syndrome (MetS); however, the development of NAFLD has some common mechanisms with the development of MetS, as they share the pathophysiologic basis of insulin resistance. It is also recognized that NAFLD is the hepatic manifestation of MetS. To define MetS, the presence of at least three of the proposed criteria is required, and sometimes it is sufficient to have only one laboratory value, modified by diet or drugs, for the classification of MetS. Ultrasonographically-detected NAFLD (US-NAFLD) is more stable, only changing during the middleto long-term. Although controversies over MetS continue, and considering that abdominal ultrasonography for diagnosing NAFLD has high specificity and guidelines to modify the natural course of NAFLD by diet composition or lifestyle have not yet been established, why should we not introduce US-NAFLD as a new criterion to define MetS? | Giovanni Tarantino Carmine Finelli | 2013 | World Journal of Gastroenterology2013，19，22： | 34 |
| 13 | 非酒精性脂肪性肝病的流行特征显示文摘目前非酒精性脂肪性肝病已成为全球最主要的慢性肝病,其患病率在不同人种、国家、区域之间均有差异。非酒精性脂肪性肝病的发病与肥胖、代谢综合征、生活方式、遗传、肌肉减少症等因素相关。目前亚洲地区非酒精性脂肪性肝病的患病率与西方国家基本持平,但其流行病学特征与西方国家仍有差异。在亚洲,非肥胖型非酒精性脂肪性肝病患者较西方更多,其发病多与遗传因素相关。慢性乙型肝炎合并脂肪性肝病患者数目较多,亦是亚洲地区的流行病学特征。 | 杨蕊旭 范建高 | 2018 | 传染病信息2018，31，2： | 33 |
| 14 | 代谢综合征与脂肪肝显示文摘代谢综合征(MS)与慢性肝病特别是脂肪肝关系密切,两者并存时的临床特征及其发病机制、诊断、治疗等方面的研究众多但结果仍有争论。介绍了MS及其相关脂肪肝与酒精性肝病和慢性病毒性肝炎临床研究的最新进展及困境,旨在帮助临床医生提高MS和脂肪肝的处理能力,更好地为此类患者服务。 | 范建高 颜士岩 | 2016 | 临床肝胆病杂志2016，32，3： | 30 |
| 15 | 某体检人群非酒精性脂肪肝的现状及其与高脂血症、肝功能异常的关系显示文摘目的了解某体检人群非酒精性脂肪肝(NAFLD)的流行现状,探讨非酒精性脂肪肝与高脂血症及肝功能异常之间的关系。方法选择2009年4月-10月至宁夏医科大学附属医院进行健康体检的机关及企、事业单位在职职工5415人作为研究对象,进行一般情况调查、现场体格检查、肝脏B超检查以及总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、天门冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)等生化指标的检测。结果该人群NAFLD患病率为12.41%,男性患病率17.09%,女性5.01%,男性患病率明显高于女性(χ^2=172.54,P〈0.01);NAFLD组高脂血症患病率为83.78%,男性患病率均明显高于女性(χ^2=16.21,P〈0.01)。以年龄分组后,男女性NAFLD患病率随年龄增加均呈上升趋势,50岁-达高峰,20岁-50岁各年龄组中,男性患病率均高于女性(χ^2=17.831,92.737,59.813,6.534,P均〈0.01)。高脂血症者患NAFLD的风险是血脂正常者的4.499倍(95%CI:3.636-5.566);高AST者患NAFLD及高脂血症的风险是AST正常者的2.563倍、2.584倍(95%CI:1.932-3.399、1.947-3.428);高ALT者患NAFLD及高脂血症的风险是ALT正常者的3.205倍、3.930倍(95%CI:2.671-3.846、3.270-4.723)。NAFLD合并腹性肥胖、高血糖、高血压、血脂异常的患病率与AST、ALT异常率分别为71.13%、30.06%、55.06%、83.78%、10.57%和32.44%,显著高于正常人群(P均〈0.01)。结论该人群NAFLD患病率处于我国人群患病率的低水平,NAFLD患者的高脂血症患病率高,NAFLD与高脂血症患者高AST、ALT的异常率高,即高脂血症显著增加了NAFLD的患病风险,高AST、高ALT可增加NAFLD及高脂血症的患病风险。 | 刘园 贺鹍鹏 强艳 刘贺荣 陈楠 宋辉 | 2015 | 宁夏医科大学学报2015，37，3： | 27 |
| 16 | 非酒精性脂肪性肝病研究进展显示文摘非酒精性脂肪性肝病(NAFLD)是一种与胰岛素抵抗和遗传易感性密切相关的代谢应激性肝损伤。随着肥胖和代谢综合征全球化的流行趋势,NAFLD已成为越来越严重的健康问题。NAFLD本身除可直接导致肝衰竭、肝细胞癌(HCC)和移植肝复发外,还可影响其他慢性肝病进展,并参与2型糖尿病和动脉硬化的发病^[1-6]。 | 范建高 | 2008 | 中华肝脏病杂志2008，16，11： | 18 |
| 17 | Alcohol consumption and metabolic syndrome among Shanghai adults: A randomized multistage stratified cluster sampling investigation显示文摘AIM: To examine the relations of alcohol consumption to the prevalence of metabolic syndrome in Shanghai adults. METHODS: We performed a cross-sectional analysis of data from the randomized multistage stratified cluster sampling of Shanghai adults, who were evaluated for alcohol consumption and each component of metabolic syndrome, using the adapted U.S. National Cholesterol Education Program criteria. Current alcohol consumption was defined as more than once of alcohol drinking per month. RESULTS: The study population consisted of 3953 participants (1524 men) with a mean age of 54.3 ± 12.1 years. Among them, 448 subjects (11.3%) were current alcohol drinkers, including 405 males and 43 females. After adjustment for age and sex, the prevalence of current alcohol drinking and metabolic syndrome in the general population of Shanghai was 13.0% and 15.3%, respectively. Compared with nondrinkers, the prevalence of hypertriglyceridemia and hypertension was higher while the prevalence of abdominal obesity, low serum high-density-lipoprotein cholesterol (HDL-C) and diabetes mellitus was lower in subjects who consumed alcohol twice or more per month, with a trend toward reducing the prevalence of metabolic syndrome. Among the current alcohol drinkers, systolic blood pressure, HDL-C, fastingplasma glucose, and prevalence of hypertriglyceridemia tended to increase with increased alcohol consumption. However, low-density-lipoprotein cholesterol concentration, prevalence of abdominal obesity, low serum HDL-C and metabolic syndrome showed the tendency to decrease. Moreover, these statistically significant differences were independent of gender and age.CONCLUSION: Current alcohol consumption is associated with a lower prevalence of metabolic syndrome irrespe- ctive of alcohol intake (g/d), and has a favorable influence on HDL-C, waist circumference, and possible diabetes mellitus. However, alcohol intake increases the likelihood of hypertension, hypertriglyceridemia and hyperglycemia. The clinical significance of these findings needs further investigation. | Jian-Gao Fan Xiao-Bu Cai Lui Li Xing-Jian Li Fei Dai Jun Zhu | 2008 | World Journal of Gastroenterology2008，14，15： | 13 |
| 18 | 陆定波治疗非酒精性脂肪肝经验显示文摘陆定波教授系湖北省中医院肝病科主任医师,全国名老中医学术继承人。从事肝病临床及研究近30余年,在肝病治疗方面积累了丰富经验,对于非酒精性脂肪肝的中医治疗有其独到的见解和体会。笔者有幸侍诊左右,现将其治疗非酒精性脂肪肝的经验整理如下。1病因辨内外、病机辨虚实祖国医学并无"非酒精性脂肪肝"的病名及诊断,但根据非酒精性脂肪肝的临床表现及证候特点。 | 朱茂龙 陆定波 | 2016 | 湖北中医杂志2016，38，11： | 13 |
| 19 | 非肥胖型非酒精性脂肪性肝病的诊治对策显示文摘非酒精性脂肪性肝病和肥胖有相关的基因,但是也可发生在人体质量指数<25 kg/m^2的非肥胖人群中。这种非肥胖型非酒精性脂肪性肝病多发生在亚洲。在肝穿刺活组织病理学检查中肥胖型和非肥胖型非酒精性脂肪性肝病没有明显的差异。内脏肥胖、高果糖和胆固醇摄入、以及遗传因素如APOC3基因变异等与非肥胖型非酒精性脂肪性肝病密切相关。一般来说,非酒精性脂肪性肝炎病死率增加,主要是心血管病因,与其他代谢因素无关。虽然关于非肥胖型非酒精性脂肪性肝病病死率影响的数据并不完整且有限,但诊断、管理、治疗可能很重要。改变生活方式以减少内脏肥胖,包括饮食变化和体力活动,仍然是非肥胖型非酒精性脂肪性肝病患者主要治疗方案。 | 陈慧婷 周永健 | 2020 | 中华肝脏病杂志2020，28，3： | 12 |
| 20 | 部队无偿献血者ALT不合格原因调查与分析显示文摘目的 分析部队无偿献血者ALT不合格原因,并提出解决对策,避免血液浪费。方法 整理2007~2012年驻连部队献血者登记信息,分为年龄因素组、体重指数组、疲劳运动组、饮酒组、肝炎病毒组和正常对照组,每组选定符合该组条件的献血者100人,分别计算ALT均值及各组ALT值异常人数和所占比例,并进行统计分析。结果 各组ALT平均值分别为年龄因素组(43.5±27.5)U/L,体重指数组(42.3±25.8)U/L,疲劳运动组(40.2±23.7)U/L,饮酒组(38.5±29.2)U/L,肝炎病毒组(27.8±15.1)U/L和正常对照组(25.5±10.8)U/L。除肝炎病毒组外,各组ALT均值与正常对照组比较差异均有统计学意义(P〈0.05)。另外,年龄因素组和体重指数组中ALT不合格比例最高分别占该组的37%和33%。结论 导致部队献血者ALT值异常的主要因素包括年龄、体重,其次为疲劳及饮酒,工作中通过合理筛选及采取相应措施,可有效避免血液资源浪费。 | 李杰 权红艳 于长江 | 2015 | 临床输血与检验2015，17，1： | 12 |
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