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1Genetic polymorphism in pathogenesis of irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS)is a complex symptombased disorder without established biomarkers or putative pathophysiology.IBS is a common functional gastrointestinal disorder which is defined as recurrent abdominal pain or discomfort that has at least two of the following symptoms for 3 d per month in the past 3mo according to ROMEⅢ:relief by defecation,onset associated with a change in stool frequency or onset with change in appearance or form of stool.Recent discoveries revealed genetic polymorphisms in specific cytokines and neuropeptides may possibly influence the frequencies and severity of symptoms,as well as the therapeutic responses in treating IBS patients.This review gives new insights on how genetic determinations influence in clinical manifestations,treatment responses and potential biomarkers of IBS.Cynthia KY Cheung Justin CY Wu 2014World Journal of Gastroenterology2014,20,47:3
2RUNX3在肿瘤中的研究进展显示文摘人类runt相关转录因子(human runt—related transcription factor,RUNX)是基因属RUNT家族,参与胚胎发育过程中细胞基因表达的调控,包括3个基因,分别是RUNXl、RUNX2、RUNX3。其中RUNX3是最小的,是哺乳动物RUNT家族进化的基础,对其研究也是最少的。李勇 孙式伟 张月峰 2014河北医科大学学报2014,35,1:1
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