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| 1 | Research on induced pluripotent stem cells and the application in ocular tissues显示文摘·Induced pluripotent stem cells(i PSCs) were firstly induced from mouse fibroblasts since 2006, and then the research on i PSCs had made great progress in the following years. i PSCs were established from different somatic cells through DNA, RNA, protein or small molecule pathways and transduction vehicles. With continuous improvement of technology on reprogramming, the induction of i PSCs became more secure and effective, and showed enormous promise for clinical applications. We reviewed different reprogramming of somatic cells, four kinds of pathways of reprogramming and three types of transduction vehicles, and discuss the research of i PSCs in ophthalmology and the prospect of i PSCs applications. | Xiao-Ling Guo Jian-Su Chen | 2015 | International Journal of Ophthalmology(English edition)2015，8，4： | 1 |
| 2 | Making cardiomyocytes with your chemistry set:Small molecule-induced cardiogenesis in somatic cells显示文摘Cell transplantation is an attractive potential therapy for heart diseases. For example, myocardial infarction(MI) is a leading cause of mortality in many countries. Numerous medical interventions have been developed to stabilize patients with MI and, although this has increased survival rates, there is currently no clinically approved method to reverse the loss of cardiac muscle cells(cardiomyocytes) that accompanies this disease. Cell transplantation has been proposed as a method to replace cardiomyocytes, but a safe and reliable source of cardiogenic cells is required. An ideal source would be the patients' own somatic tissue cells, which could be converted into cardiogenic cells and transplanted into the site of MI. However, these are difficult to produce in large quantities and standardized protocols to produce cardiac cells would be advantageous for the research community. To achieve these research goals, small molecules represent attractive tools to control cell behavior. In this editorial, we introduce the use of small molecules in stem cell research and summarize their application to the induction of cardiogenesis in noncardiac cells. Exciting new developments in this field are discussed, which we hope will encourage cardiac stem cell biologists to further consider employing small molecules in their culture protocols. | Woong-Hee Kim Da-Woon Jung Darren Reece Williams | 2015 | World Journal of Cardiology2015，7，3： | 0 |
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