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| 1 | Salidroside inhibits H2O2-induced apoptosis in PC12 cells by preventing cytochrome c release and inactivating of caspase cascade显示文摘我们使用了老鼠 pheochromocytoma (PC 12 ) 在氢过氧化物上学习 salidroside 的效果的房间线(H 2 O 2)-induced apoptosis。在 PC12 房间, H 2 O 2-induced apoptosis 被 Bcl-2, Bax 的起来规定,到 cytosol 的 mitochondrial 细胞色素 c 的版本,和 caspase-3, -8 和 -9 的激活的下面规定伴随。然而, salidroside 压制了 Bcl-2, Bax 的起来规定和 mitochondrial 细胞色素 c 的版本的下面规定到 cytosol。而且, salidroside 对 H 2 O 2-induced apoptosis。总起来说,这些结果建议有 salidroside 的 PC12 房间的处理能堵住 H 2 由调整 Bcl-2 家庭成员并且由压制细胞色素 c 版本和 caspase 串联激活的 O 2-induced apoptosis。 | Lei Cai Hua Wang Qin Li Yunfei Qian Wenbing Yao | 2008 | Acta Biochimica et Biophysica Sinica2008，40，9： | 18 |
| 2 | 百草枯中毒的损伤机制和治疗进展显示文摘 | 陈国柱 史忠 高全杰 | 2008 | 重庆医学2008，37，22： | 11 |
| 3 | Edaravone attenuates paraquat-induced lung injury by inhibiting oxidative stress in human type Ⅱalveolar epithelial cells显示文摘BACKGROUND:Edaravone(3-methyl-1-penyl-2-pyrazolin-5-one) is a potent free-radical scavenger and has the antioxidant ability to inhibit lipid peroxidation.The study aimed to examine the effect of edaravone on protecting the acute injury of human type II alveolar epithelial cells(A549cells) induced by paraquat(PQ) and the change of production of reactive oxygen species(ROS),malondialdehyde(MDA),superoxide dismutase(SOD).METHODS:A549 cells were cultured and divided into PQ group(group P),edaravone-treated group(group E) and normal control group(group C).The cells in group P were exposed to paraquat(600 umol/L),and the cells in group E were treated with edaravone(100 umol/L) additionally,and no drug intervention was given to the cells in group C.Real-time monitoring by LSCM was used to detect the cell response and the intracellular dynamic change of ROS level in A549 cells after administration of PQ and edaravone.And the levels of SOD and MDA were detected respectively by biochemistry colorimetry.Data were expressed as mean ± standard error of the mean.Statistical analysis was carried out with the soft SPSS 16.0.RESULTS:The concentration of intracellular ROS significantly increased when PQ was given to A549 cells.But after administration of edaravone,the concentration of intracellular ROS was decreased.Compared to the PQ group,the levels of SOD in the edaravone group were significantly increased while the levels of MDA were markedly decreased.CONCLUSIONS:Paraquat can increase the oxidative stress,and induce the lipid peroxidation of A549 cells.Edaravone has the effect to scavenge reactive oxygen species,and to protect against the PQ-induced lung toxicity. | Zhi-qiang Cheng Ji-yuan Han Peng Sun Yu-ying Weng Jiao Chen Guo-yan Wu Hong-xia Ma | 2012 | World Journal of Emergency Medicine2012，3，1： | 8 |
| 4 | Toxic influence of chronic oral administration of paraquat on nigrostriatal dopaminergic neurons in C57BL/6 mice显示文摘背景 Paraquat (PQ;1,1'-dimethyl-4,4'-bipyridinium ) ,广泛地使用的除草剂,反复为 Parkinson 的疾病(PD ) 的发展作为一个潜在的 etiologic 因素被建议了,由于它到已知的 dopaminergic neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP ) 的结构的类似。这研究试图在 C57BL/6 老鼠在 nigrostriatal dopaminergic 神经原上观察 paraquat 的影响。24 只男 C57BL/6 老鼠全部的方法 A 随机被分到 3 个组:控制组(对待由盐) , PQ 对待组,和 MPTP 对待的组。在对待的组每天与 PQ (10 mg/kg ) 口头上地被当作四个月的 PQ 的老鼠。运动活动被测量。多巴胺(DA ) 的水平和它在 striatum 的代谢物层次被高效的液体测量有一个电气化学的察觉者(HPLC-ECD ) 的层析,和酷氨酸 hydroxylase (TH ) 积极神经原被使用 immunohistochemistry 检测。同时, superoxide dismutase (草皮)的活动和谷胱甘肽 peroxidase ( GSH-PX ),和在 substantia nigra 的 malondialdehyde ( MDA )的内容被 spectrophotometry 测量,在 substantia nigra 的 dopaminergic 神经原的多巴胺 transporter ( DAT )的 mRNA 表示被反向的抄写( RT )也决定 -PCR 技术。结果运动活动显著地在 PQ 被损害对待的组。DA 的水平和它在 striatum 的代谢物层次被拒绝。草皮和 GSH-PX 的活动被减少,并且 MDA 的内容在 PQ 被增加在控制与那相比对待老鼠组。TH 积极神经原和在鼠标的 substantia nigra 的 DAT 的 mRNA 表达式的数字也在口头上地拿四个月的 PQ 以后被减少。 | REN Jin-peng ZHAO Yu-wu SUN Xiao-jiang | 2009 | Chinese Medical Journal2009，，19： | 6 |
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