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| 1 | Does repair of spinal cord injury follow the evolutionary theory?显示文摘Lower vertebrates,such as fish and amphibians,and higher vertebrates in embryonic development can acquire complete regeneration of complex body structures,including the spinal cord,an important part of the central nervous system.However,with species evolution and development,this regenerative capacity gradually weakens and even disappears,but the cellular and molecular mechanisms remain poorly understood.We explored the differences in mechanisms of spinal cord regeneration capability between lower and higher vertebrates,investigated differences in their cellular and molecular mechanisms and between the spinal cord structures of lower vertebrates and mammals,such as rat and monkey,to search for theoretical evidence and therapeutic targets for nerve regeneration in human spinal cord. | Zhicheng Zhang Fang Li Tiansheng Sun | 2012 | Neural Regeneration Research2012，7，11： | 1 |
| 2 | Why does a little mean a lot when you have nothing? A brief review of cell therapy strategies for spinal cord injury显示文摘Without an understanding of functional musculoskeletal system recovery, the translation of knowledge concerning neurological recovery from laboratory discoveries to bedside applications will be incomplete. Because improvements in neurological function after cell transplantation are minor and can be easily ignored, this article draws attention to the minimal improvements required to allow a spinal cord injury patient or person to live a relatively independent life. These minimal improvements include(1) the key muscle power required for trunk stability;(2) the key muscle power required to allow a paraplegic to walk; and(3) the key muscle power required for hand usefulness or functionality. The system of muscle power grading promoted by the British Medical Research Council(MRC) is more sensitive and delicate than the ASIA Standards, as the latter only accept the full range of movement of a joint. The MRC system seems to be preferable to the ASIA Standards in clinical trials of cell transplantation, wherein minute improvements in function might result in large differences in the quality of life. The threshold of function is a grade 3 power level. Even if all relevant muscles fail to achieve a power higher than grade 3, the patient can be minimally functional and hence relatively independent. These relevant muscles include the latissimus dorsi, hip flexors, hip abductors, shoulder abductors and flexors, elbow flexors and extensors,and wrist extensors. These muscles are innervated by the C5–7 spinal cord segments except the latissimus dorsi, for which innervation extends to C8. | Dajue Wang | 2015 | Translational Neuroscience and Clinics2015，1，2： | 1 |
| 3 | Evolution and restoration of structures and functions of the human central nervous system—A review显示文摘Clinical translational science:Clinical translational science(CTS)is a new discipline bridging laboratory discoveries and clinical applications.It is normally funded by research grants instead of investment major pharmaceutical companies.It is patient-and populationor community-oriented.Repair of the human | Dajue Wang | 2015 | Translational Neuroscience and Clinics2015，1，1： | 0 |
| 4 | A combination of chondroitinase ABC,glial cell line-derived neurotrophic factor,and Nogo A antibody delayed-release microspheres for the treatment of spinal cord injury显示文摘The purpose of this study was to evaluate the effect of poly(lactide-co-glycolic acid) delayed-release microspheres,which were prepared using glial cell line-derived neurotrophic factor(GDNF),on the delayed-release,controllability,and protection of GDNF activity.The present study is the first to combine chondroitinase ABC,GDNF,and Nogo A antibody delayed-release microspheres for the treatment of spinal cord injury.Results show that the combined therapy of chondroitinase ABC,GDNF,and Nogo A antibody microspheres can increase the immunoreaction of neurofilament 200 in the injured spinal cord,and this therapeutic effect was better than chondroitinase ABC,GDNF,or Nogo A antibody microspheres administered singularly. | Yu Zhang Yueming Song | 2011 | Neural Regeneration Research2011，6，10： | 0 |
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