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| 1 | 中国恶性肿瘤流行情况及防控现状显示文摘癌症是危害中国居民健康的疾病之一。其每年发病数和死亡数分别占全球的23.7%和30%。由于人口老龄化、工业化、城市化进程的加剧,生活方式的改变等原因,中国癌症的发病数和死亡数仍持续增加,癌症负担已不容忽视。癌症的发生发展是遗传和环境相互作用的结果,除年龄因素外,感染、不良生活方式等与癌症的发病密切相关。目前,国内癌症防控形势严峻,面临极大的挑战,如何实施系统的预防措施,有效降低癌症发病率和死亡率是亟待解决的问题。 | 曹毛毛 陈万青 | 2019 | 中国肿瘤临床2019，0，3： | 601 |
| 2 | Nitrosamine and related food intake and gastric and oesophageal cancer risk: A systematic review of the epidemiological evidence显示文摘瞄准:学习在亚硝酸根和亚硝基胺吸入和胃的癌症(GC ) 之间的协会在肉和处理的肉吸入之间, GC 和食道的癌症(OC ) ,并且在保存的鱼,蔬菜和吸的食物摄取和 GC 之间。方法:在这篇文章,我们从 1985-2005 考察了所有出版的队和盒子控制研究,并且分析了在亚硝基胺和亚硝酸根吸入和最重要的相关食物摄取(喝的肉和处理的肉,保存蔬菜和鱼,吸的食物和啤酒) 和 GC 或 OC 风险之间的关系。61 研究, 11 个队和 50 盒子控制研究被包括。结果:从盒子控制研究的证据与 GC 支持了在亚硝酸根和亚硝基胺吸入之间的一个协会,但是证据在与 OC 的关系是不够的。盒子控制研究的一个高比例为两个瘤(GC 上的 16 研究中的 11 个和 OC 上的 18 研究中的 11 个) 与肉吸入发现了一个积极协会。盒子控制研究的一个相对大的数字显示出支持在处理的肉吸入和 GC 和 OC 风险之间的一个积极协会的相当一致的结果(GC 上的 14 研究中的 10 个和 9 中的 8 个在 OC 上学习) 。几乎所有盒子控制研究发现了在保存的鱼,蔬菜和吸的食物摄取和 GC 之间的一个积极、重要的协会。关于 OC 的证据是更有限的。从队的证据学习的外套从盒子控制研究比那不够或更不一致。结论:可得到的证据支持在亚硝酸根和亚硝基胺吸入和 GC 之间的一个积极协会,在肉和处理的肉吸入和 GC 和 OC 之间,并且在保存的鱼,蔬菜和吸的食物摄取和 GC 之间,但是不是最后的。 | Paula Jakszyn Carlos Alberto González | 2006 | World Journal of Gastroenterology2006，12，27： | 42 |
| 3 | Risk factors for the gastric cardia cancer: a case-control study in Fujian Province显示文摘AIM: The incidence of gastric cardia cancer has greatlyincreased in the past 2-3 decades, however, the risk factorsfor the disease are still not clearly understood. Theinvestigations among Chinese population on the risk factorsof gastric cardia cancer were also scarcely reported. Wetherefore conducted a case-control study in Fujian province,China, to investigate the potential risk and protective factorsof this disease.METHODS: 191 cardia and 190 non-cardia gastric cancercases, and a total of 222 control cases were included in thisstudy. Standard questionnaires were used in collectingepidemiological factors and the data were then analyzed bythe unconditional logistic regression model.RESULTS: As the factors such as age, gender, smoking,alcohol consumption, and family history of gastric cancerwere controlled, a multivariable analysis was conducted,which revealed that there was a significant correlationbetween the dietary habits such as irregular meal, over andfast eating, and the gastric cardia cancer with the odds ratios(ORs) of 4.2 (95 % confidence interval: 2.3-7.7), 4.7 (2.1-10.8), and 2.7 (1.3-5.3) respectively. Other correlations werealso observed between the gastric cardia cancer and theconsumption of salty fish or pickled vegetable, smoking,and the family cancer history with the ORs of 5.5 (1.4-19.5),1.8 (1.0-3.0), 2.1 (1.3-3.5), and 3.8 (2.3-6.2) respectively.In contrast, the negative correlations were found existingbetween the intake of fresh vegetables and fruits, the useof refrigerator, and the gastric cardia cancer, with the ORsof 0.4 (0.2-0.9), 0.2 (0.1-0.5), and 0.2 (0.1-0.4),respectively. However, dietary habits were associated lesswith non-cardia gastric cancer compared with its cardiacounterpart.CONCLUSION: Dietary habits might be one of the riskfactors for the cardia carcinogenesis among Chinesepopulation. | LinCai Zong-LiZheng Zuo-FengZhang | 2003 | World Journal of Gastroenterology2003，9，2： | 30 |
| 4 | Glutathione S-transferases M1,T1 genotypes and the risk of gastric cancer:A case-control study显示文摘AIM Glutathione S-transferases (GSTs are involved in the detoxification of many potential carcinogens and appear to play a critical role in the protection from the effects of carcinogens. The contribution of glutathione Stransferases M1 and T1 genotypes to susceptibility to the risk of gastric cancer and their interaction with cigarette smoking are still unclear. The aim of this study was to determine whether there was any relationship between genetic polymorphisms of GSTM1 and GSTT1 and gastric cancer.METHODS A population based case - control study was carried out in a high-risk area, Changle County, Fujian Province, China. The epidemiological data were collected by a standard questionnaire and blood samples were obtained from 95 incidence gastric cancer cases and 94 healthy controls. A polymerase chain reaction method was used to detect the presence or absence of the GSTM1 and GSTT1 genes in genomic DNA. Logistic regression model was employed in the data analysis.RESULTS An increase in risk for gastric cancer was found among carriers of GSTM1 null genotype. The adjusted odds ratio (OR) was 2.63 [95% Confidence Interval (95% CI) 1.17-5.88], after controlling for age,gender, cigarette smoking, alcohol drinking, and fish sauce intake. The frequency of GSTT1 null genotype in cancer cases (43.16%) was not significantly different from that in controls (50.00%). However, the risk for gastric cancer in those with GSTM1 null and GSTT1 nonnull genotype was significantly higher than in those with both GSTM1 and GSTT1 non-null genotype (OR = 2.77,95% Cl 1.15- 6.77). Compared with those subjects who never smoked and had normal GSTM1 genotype, Ors were 1.60 (95% CI: 0.62- 4.19) for never smokers with GSTM1 null type, 2.33 (95% CI 0.88- 6.28) for smokers with normal GSTM1, and 8.06 (95% CI 2.83- 23.67) for smokers with GSTM1 null type.CONCLUSIONS GSTM1 gene polymorphisms may be associated with genetic susceptibility of stomach cancer and may modulate tobacco-related carcinogenesis of gastric cancer. | Lin Cai Shun-Zhang Yu Zuo-Feng Zhang Department of Epidemiology.Fujian Medical University,Fuzhou 350004,Fujian Province,ChinaDepartment of Epidemiology,Shanghai Medical University,Shanghai 200032,China Department of Epidemiology,UCLA School of Public Health,Los Angeles California,USA | 2001 | World Journal of Gastroenterology2001，7，4： | 22 |
| 5 | Fish sauce and gastric cancer:an ecological study in Fujian Province,China显示文摘AIM To explore the relationship betweenconsumption of fish sauce and the risk of gastriccancer in Fujian Province.METHODS An ecological study was carriedout.A total of 11000 subjects from 55 townshipswere randomly selected from 10 counties withinFujian Province.All subjects were localresidents who had been living in Fujian Provincefor more than 20 years,within the age group of45-74 years.Trained interviewers conductedface-to-face interviews with a standardizedquestionnaire,which covered the frequency andamount of food intake,dietary habit,tobaccoand alcohol consumption and history of chronicgastric diseases.Univariate and multivariateanalyses were performed using Epi-info and SASstatistical packages,respectively.RESULTS A significant correlation betweenmonthly consumption of fish sauce and mortalityof gastric cancer was found.Pearson’scoefficient of correlation was statisticallysignificant with r=0.7356 for males,r=0.5246for females(P<0.01).In the multivariateanalysis,consumption of fish sauce still showedan association with the risk of gastric cancer.No significant positive correlation betweenesophagus cancer,liver cancer,colon cancerand consumption of fish sauce were observed.CONCLUSION Long-term intake of fish saucemay be related to high mortality of gastriccancer.Consumption of fish sauce might be oneof important and unique etiologic factors ofgastric cancer in Fujian Province.Furtherstudies are needed to confirm this ecologicalstudy. | Lin Cai Shun Zhang Yu Wei Min Ye Ying Nan Yi | 2000 | World Journal of Gastroenterology2000，6，5： | 18 |
| 6 | Association between pepsinogen C gene polymorphism and genetic predisposition to gastric cancer显示文摘AIM: To identify a molecular marker for gastric cancer, andto investigate the relationship between the polymorphismof pepsinogen C (PGC) gene and the genetic predispositionto gastric cancer.METHODS: A total of 289 cases were involved in this study.115 cases came from Shenyang area, a low risk area ofgastric cancer, including 42 unrelated controls and 73 patientswith gastric cancer. 174 cases came from Zhuanghe area, ahigh-risk area of gastric cancer, including 113 unrelatedcontrols, and 61 cases from gastric cancer kindred families.The polymorphism of PGC gene was detected by polymerasechain reaction (PCR) and the relation between the geneticpolymorphism of PGC and gastric cancer was examined.RESULTS: Four alleles, 310bp (allele 1), 400bp (allele 2),450bp (allele 3), and 480bp (allele 4) were detected byPCR. The frequency of allele 1 was higher in patients withgastric cancer than that in controls. Genotypes containinghomogenous allele 1 were significantly more frequent inpatients with gastric cancerthan that in controls (0.33, 0.14,x2=3.86, P<0.05). There was no significant differencebetween the control group of Zhuanghe and the group ofgastric cancer kindred. But the frequency of allele 1 washigher in control group of Zhuanghe area than that in controlgroup of Shenyang area and genotypes containinghomogenous allele 1 were significantly more frequent inthe control group of Zhuanghe area than those in controlgroup of Shenyang area (0.33, 0.14, x2=4.32, P<0.05). Inthe group of gastric cancer kindred the frequency of allele 1was significantly higher than that in control group ofShenyang area (0.5164, 0.3571, x2=4.47, P<0.05).Genotypes containing homogenous allele 1 were significantlymore frequent in the group of gastric cancer kindred thanthose in control group of Shenyang area (0.36, 0.14, x2=4.91,P<0.05).CONCLUSION: These results suggest that there is somerelation between pepsinogen C gene polymorphism andgastric cancer, and the person with homogenous allele 1predisposes to gastric cancer than those with othergenotypes. Pepsinogen C gene polymorphism may be usedas a genetic marker for a genetic predisposition to gastriccancer. The distribution of pepsinogen C gene polymorphismin Zhuanghe, a high-risk area of gastric cancer, is differentfrom that in Shenyang, a low risk area of gastric cancer. | Hui-Jie Liu Xiao-Lin Guo Ming Dong Lan Wang Yuan Yuan Cancer Institute,First Affiliated Hospital,China Medical University,Shenyang,110001,Liaoning Province,China | 2003 | World Journal of Gastroenterology2003，9，1： | 16 |
| 7 | 人胃癌细胞端粒酶RNA组分hTR基因片段的克隆及其正反义真核表达载体的构建显示文摘目的克隆人胃癌细胞端粒酶RNA组分(hTR)基因片段并构建其正义和反义真核表达载体,为以端粒酶为靶目标的肿瘤基因治疗奠定基础。方法采用RT-PCR方法从人胃癌细胞株MKN-45中扩增出人hTR部分cDNA序列。将该片段插入pEF6/V5-His-TOPO载体后构建人端粒酶RNA组分(hTR)基因正义真核表达载体(pEF-hTR)。随后采用EcoRV和SpeⅠ从pEF-hTR上切下该目的基因片段并反向插入pBluescriptⅡKS载体上的EcoRV/SpeⅠ酶切位点上。最后采用KpnⅠ和NotⅠ从pBluescriptⅡKS载体上切下该目的基因片段并正向插入pEF-hTR的KpnⅠ/NotⅠ酶切位点上从而构建出人端粒酶RNA组分(hTR)基因反义真核表达载体(pEF-ahTR)。对所构建的载体均进行酶切鉴定和测序确认。结果所克隆的基因片段其碱基序列与文献报道完全一致,且插入载体的方向完全正确。结论本实验已成功克隆了人端粒酶RNA组分(hTR)基因的部分序列并成功构建其正义、反义真核表达载体,从而为研究反义抑制人胃癌细胞端粒酶活性对胃癌细胞生物学行为的影响奠定了基础。 | 冯润华 李建芳 刘炳亚 朱正纲 尹浩然 | 2001 | 世界华人消化杂志2001，9，12： | 11 |
| 8 | Construction of cDNA representational difference analysis based on two cDNA libraries and identification of garlic inducible expression genes in human gastric cancer cells显示文摘AIM: To elucidate molecular mechanism of chemopreventiveefficacies of garlic against human gastric cancer (HGC):METHODS: HGC cell line BGC823 was treated with Allitridi (akind of garlic extract) and Allitridi-treated and parentalBGC823 cDNA librarles were constructed respectively byusing λZAP Ⅱ vector. cDNA Representatinal DifferenceAnalysis (cDNA RDA) was perfonmed using BamH Ⅰ cutting-site and abundant ~DNA messages provided by the Iibrarles.Northern blot analysls was applied to identifythe obtaineddifference prnducts.RESULTS: Two specific cDNA fragments were obtained andcharacterized to be derived from homo sapiens folatereceptorα (FRα) gene and calcyclin gene respectively.Northern blot results showed a 4-fold increase in FRα geneexpression level and 9-fold increase in calcyclin mRNA levelin BGC823 cells after Allilridi treatment for 72 h.CONCLUSION: The method of cDNA RDA based on cDNAlibraries combines the high specificity of cDNA RDA withabundant cDNA messages in cDNA library; this expands theapplication of cDNA library and increases the specificity ofcDNA RDA. Up-regulstion of FRα gene and calcyclin geneexpressions induced by Allitridi provide valuable molecularevidence for theefficacy of garlic in treating HGC as well asother diseases. | Yong Li Jian-Tao Cui Wen-Mei Li You-Yong Lu,Beijing Institute for Cancer Research,Beijing Laboratory of Molecular Oncology,School of Oncology,Peking University,Beijing 100034,China Lin Yang,Department of Gastroenterology,PLA Institute for Digestive Diseases,First Affiliated Hospital of First Military Medical University,Chinese,Guangzhou,510000,Guangdong Province,China Rui-Fang Guo,Department of Physiology,Neimenggu Medical College,Huhehaote,010000,Neimengguzizhiqu,China | 2002 | World Journal of Gastroenterology2002，8，2： | 10 |
| 9 | Research and control of well water pollution in high esophageal cancer areas显示文摘AIM: In order to detect risk factors for esophageal cancer,a national research program was carried out during the Eighth Five-Year Plan (from 1991 to 1995).
METHODS: Cixian County and Chichen County in Hebei Province were selected as the index and the control for the study fields with higher or lower incidence of esophagus cancer in China, respectively. In these areas, we investigated the pollution of three nitrogenous compounds in well water for drinking and the use of nitrogen fertilizer in farming.
RESULTS: In well water, nitrate nitrogen, nitrite nitrogen and ammonia nitrogen were 8.77 mg/L, 0.014 mg/L and 0.009 mg/L in Cixian County in 1993, respectively. They were significantly higher than their levels (3.84 mg/L, 0.004 mg/L and 0.004 mg/L) in Chichen County (P<0.01, t=6.281,t=3.784,t=3.775). There was a trend that the nitrogenous compounds in well water increased from 1993 to 1996.The amount of nitrogen fertilizer used in farming was 787.6 kg per hectare land in Cixian County in 1991, significantly higher than 186 kg per hectare in Chichen County (t=9.603,P<0.001).
CONCLUSION: These investigations indicate that the poilution of nitrogenous compounds in well water for drinking is closely related to the use of nitrogen fertlizer in farming, and there is a significantly positive correlation between the level of three nitrogenous compounds in well water and the mortality ofesophageal cancer (correlation coefficient =0.5992). We suggest that improvement of well system for drinking water quality should be an effective measure for esophageal cancer prevention and control in rural areas. | Xiu-LanZhang BingZhang XingZhang Zhi-FengChen Jun-ZhenZhang Shuo-YuangLiang Fan-ShuMen Shu-LiangZheng Xiang-PingLi Xiu-LanBai | 2003 | World Journal of Gastroenterology2003，9，6： | 7 |
| 10 | 维吾尔族胃癌138例临床分析显示文摘目的:探讨本地区的维吾尔族(维族)胃癌的发病情况、临床病理特点。方法:回顾分析1995年1月~2003年12月在我院住院治疗的维族胃癌患者138例,汉族胃癌患者356例。结果:胃癌发病情况:男性多于女性,维族胃癌患者发病人数少于汉族,41~50岁年龄段维族胃癌患者发病人数显著高于同年龄段的汉族患者(x2=6.3935.P<0.05).60岁以上患者中汉族患者发病人数多于同年龄段的维族患者.且差异均有统计学意义(x2=3.9963,P<0.05);维族胃体癌发生率明显高于汉族.差异有统计学意义(x2=5.0553,P<0.05);而汉族胃窦癌发生率明显高于维族,差异有统计学意义(x2=12.4152,P<0.05)。结论:维族胃癌发病人数少于汉族,维族及汉族胃癌发病情况与一般胃癌发病危险因素的流行病学特点不同,原因有待分子遗传学方面的研究来证实。 | 派祖拉.马木提 艾孜买提.热合木吐拉 | 2005 | 新疆医科大学学报2005，28，7： | 5 |
| 11 | Effect of jianpiyiwei capsule on gastric precancerous lesions in rats显示文摘AIM:To evaluate the therapeutic effect of compoundChinese drugs, Jianpiyiwei capsule (JPYW) on gastricprecancerous lesions in rats and to explore itsmechanism of action.METHODS:Model of gastric precancerous lesions wasconstructed in male Wistar rats: a metal spring wasinserted and fixed through pyloric sphincter. One weekafter recovery, each rat was given 50-60 ℃ hot pastecontainingt50 g/L NaCl 2 mL orally, twice a week for15 weeks.Then 10 normal and 11 model rats wereanaesthetized, after the measurement of gastricmucosa blood flow (GMBF), the rats were killed andthe mucosal hexosamines and malonic dialdehyde(MDA) were measured. The morphological changes ofgastric mucosa were observed macroscopically andmicroscopically, and by an automatic imaging analysissystem. Other rats were treated with JPYW 1.5 g/kg.d-1or 4.5 g/kg@d-1, or distilled water as negative controlrespectively (n=-10 in each group). After 12 weeks, allthe rats were examined as above.RESULTS: The gastric mucosa of model rats showedchronic atrophic gastritis with dysplasia and intestinalmetaplasia (IM), GMBF and hexosamine content werereduced significantly and MDA was increased ascompared to the normal group (P<0.01). After 12 weekstreatment, the pathological changes of the negativecontrol group became worsened, while in JPYW treatedgroups the changes were modified with significantincrease of GMBF and reduction of MDA, although thehexosamine concentration increased only mildly.CONCLUSION: JPYW increases GMBF and reduces MDAcontent in gastric mucosa and has therapeutic effectson gastric precancerous lesions. | Xue-YingShi Feng-ZhiZhao | 2002 | World Journal of Gastroenterology2002，8，4： | 4 |
| 12 | 胃癌患者524例临床分析显示文摘胃癌的发病率在世界各地及各民族,以及在一个国家各民族之间有差异;可能与他们所在的环境及遗传背景有关[1,2].此外胃癌的发病部位在种族之间也有所不同.胃癌在我国居癌症发病率之首,肿瘤死因中也占第一位.我们新疆维吾尔自治区是一个多民族地区,迄今有关胃癌在新疆各民族中发病情况无系统性的研究及统计.本文通过回顾性的分析1995年1月~2003年12月在我院住院治疗的本地区各民族胃癌患者共524例,初步探讨生活在本地区的维吾尔族胃癌及部位的发病情况,性别、年龄特点,临床病理特点等. | 派祖拉.马木提 艾孜买提 | 2005 | 新疆医学2005，35，2： | 0 |
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