共被期刊论文引用了4次
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| 1 | Exploring the role of microRNAs in tumorigenesis显示文摘Recent years,one of the most striking findings in the field of biomedical science is the identification of miRNAs,which are small endogenous non-coding transcripts of*22nucleotides.miRNAs are thought to bind to the complementary sites in their 30-untranslated region(30-UTR)of target mRNAs,and in turn modulate the stability and translational potentiality of these mRNA targets.It has been well documented that miRNAs play important roles in various important biological processes including embryo- | Qimin Zhan | 2014 | Chinese Science Bulletin2014，59，19： | 2 |
| 2 | microRNA-10b及靶基因HOXD10在肝癌细胞中的表达及侵袭能力的影响显示文摘目的探讨micro RNA-10b(mi R-10b)及其靶基因同源异性盒基因HOXD10在肝癌细胞中的表达及转染mi R-10b对肝癌细胞侵袭性能力的影响。方法分析HOXD10基因在3种肝癌细胞株Huh7、Hep G2、SMMC-7721中的基础表达量,筛选出HOXD10基础表达量高的Hep G2作为后续研究对象。设计合成外源性mi R-10b序列,用脂质体瞬时转染肝癌细胞株,设置mi R-10b转染组、无关序列转染组(阴性对照组)和未处理组(对照组)。用RT-PCR及Western blot检测肝癌细胞转染mi R-10b后HOXD10基因及蛋白表达量的变化,细胞侵袭实验研究转染mi R-10b对肝癌细胞侵袭能力。结果在基因水平和Western blot分析蛋白水平HOXD10基因表达量2-ΔΔCT分别是(1.24±0.23)、(1.00±0.02),P>0.05差异无统计学意义。在蛋白分析Hep G2细胞灰度计算值是值分别是653.492和1 968.742,蛋白水平表达降低。HOXD10基因在肝癌细胞株Hep G2的表达量显著高于Huh7和SMMC-7721;mi R-10b成功转染Hep G2后,HOXD10基因表达水平与对照组比较无明显变化,但HOXD10蛋白表达量与对照组比较下降及侵袭性也增强。结论 mi R-10b可能通过抑制靶基因HOXD10表达发挥作用,促进肝癌细胞的侵袭。 | 熊建宁 胡立春 王亚兵 段雪飞 | 2016 | 中国现代医学杂志2016，26，6： | 0 |
| 3 | Reflection on micro RNAs in cancer: the next decade显示文摘When researchers find molecules or pathways that are critical for development and homeostasis of cells,tumors always hijacked them for their own villainies.Thus,it is not surprising that dysregulation of micro RNAs in almost all types of cancer,for example,mi R-15/16 was | Gang Ma Zhihua Liu | 2015 | Science Bulletin2015，60，24： | 0 |
| 4 | From Chinese Science Bulletin to Science Bulletin: celebrate the coming 50th birthday显示文摘As the only multidisciplinary journal supervised by Chinese Academy of Sciences and the National Natural Science Foundation of China,Science Bulletin will usher in its50th anniversary in 2016.A fifty-year history for a journal is always remarkable.However,the more important reason to celebrate besides the great age is:the fifty-year old journal continues to be vigorous and influential. | Xuming Jia Rui An Xiao-Ya Chen | 2015 | Science Bulletin2015，60，24： | 0 |
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